Abnormal resting‐state functional connectivity in posterior cingulate cortex of Parkinson's disease with mild cognitive impairment and dementia

Zhan, Zhouwei; Lin, Lizhen; Yu, Er-Han; Xin, Jiawei; Lin, Lin; Lin, Hailong; Ye, Qinyong; Chen, Xiaochun; Pan, Xiaodong

doi:10.1111/cns.12838

Cited by 51 publications

(61 citation statements)

References 33 publications

(67 reference statements)

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“…Interestingly, functional connectivity deterioration in posterior cortical regions has been associated with progression of cognitive impairment over 3 years in a longitudinal fMRI study [98]. Moreover, alterations within the DMN have been shown to be more relevant in PD patients with MCI [99][100][101] and with dementia [97,[101][102][103], further supporting the potential role of RS-fMRI to depict a sensitive and specific biomarker of dementia in PD for prognostic and disease-monitoring purposes.…”

Section: Premotor Phase and Non-motor Symptoms Correlatesmentioning

confidence: 89%

Functional Connectivity Signatures of Parkinson’s Disease

Tessitore

Cirillo

Micco

2019

JPD

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Resting-state functional magnetic resonance imaging (RS-fMRI) studies have been extensively applied to analyze the pathophysiology of neurodegenerative disorders such as Parkinson's disease (PD). In the present narrative review, we attempt to summarize the most recent RS-fMRI findings highlighting the role of brain networks reorganization and adaptation in the course of PD. We also discuss limitations and potential definition of early functional connectivity signatures to track and predict future PD progression. Understanding the neural correlates and potential predisposing factors of clinical progression and complication will be crucial to guide novel clinical trials and to foster preventive strategies.

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Section: Premotor Phase and Non-motor Symptoms Correlatesmentioning

confidence: 89%

Functional Connectivity Signatures of Parkinson’s Disease

Tessitore

Cirillo

Micco

2019

JPD

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“…In addition, studies have found that Parkinson's disease (PD), Huntington's disease, schizophrenia, major depressive disorder, type 2 diabetes mellitus (T2DM), chronic obstructive pulmonary disease (COPD), lung cancer following chemotherapy, hepatic encephalopathy, kidney deficiency syndrome, and other diseases can also cause CI (70)(71)(72)(73)(74)(75)(76)(77)(78)(79), but the relationships between these diseases and cognitive function and the pathogenesis of CI are still unknown, necessitating further in-depth studies. rs-fMRI will play an important role in the exploration of these unknown areas.…”

Section: Application Of Rs-fmri In Mild Traumatic Brain Injury (Mtbi)mentioning

confidence: 99%

The Application of rs-fMRI in Vascular Cognitive Impairment

et al. 2020

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The incidence of vascular cognitive impairment (VCI) has been increasing for years and has become a major disabling factor in middle-aged and elderly populations. The pathogenesis of VCI is unclear, and there are no standard diagnostic criteria. Resting-state functional magnetic resonance imaging (rs-fMRI) can be used to detect spontaneous brain functional activity in a resting state, which facilitates in-depth investigation of the pathogenesis of VCI and provides an objective reference for early diagnosis, differential diagnosis, and prognostic evaluation. This article mainly reviews the principle and analysis of rs-fMRI data, as well as the progress of its application for VCI diagnosis.

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“…FMRI studies showed that all the resting‐state functional networks underlying the main cognitive functions, such as the default mode, dorsal‐attention, frontoparietal, salience, and associative visual networks, are altered in patients with PD . Also, functional connectivity disruption of specific brain areas such as the temporal, parietal, and occipital regions has been found in PD patients with memory and visuospatial deficits …”

Section: Introductionmentioning

confidence: 99%

“…Importantly, in early PD patients, the disrupted functional connectivity of the default mode network has been found to be predictive of cognitive decline with disease progression . Default mode network alterations worsen in PD patients with mild cognitive impairment (MCI) and dementia, and this process is associated with a progressive cognitive decline over a three‐year follow‐up in PD dementia patients . Interestingly, one study suggested that cognitively unimpaired PD patients showed a hyperconnectivity of cortical, limbic, and basal ganglia‐thalamic areas, which has been suggested as a compensatory mechanism preceding cognitive decline …”

Section: Introductionmentioning

confidence: 99%

Resting‐state Functional MRI in Parkinsonian Syndromes

Filippi

Sarasso

Agosta

2019

Movement Disord Clin Pract

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Background Background: Functional MRI (fMRI) has been widely used to study abnormal patterns of functional connectivity at rest in patients with movement disorders such as idiopathic Parkinson's disease (PD) and atypical parkinsonisms. Methods Methods: This manuscript provides an educational review of the current use of resting-state fMRI in the field of parkinsonian syndromes. ResultsResults: Resting-state fMRI studies have improved the current knowledge about the mechanisms underlying motor and non-motor symptom development and progression in movement disorders. Even if its inclusion in clinical practice is still far away, resting-state fMRI has the potential to be a promising biomarker for early disease detection and prediction. It may also aid in differential diagnosis and monitoring brain responses to therapeutic agents and neurorehabilitation strategies in different movement disorders. ConclusionsConclusions: There is urgent need to identify and validate prodromal biomarkers in PD patients, to perform further studies assessing both overlapping and disease-specific fMRI abnormalities among parkinsonian syndromes, and to continue technical advances to fully realize the potential of fMRI as a tool to monitor the efficacy of chronic therapies.

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Abnormal resting‐state functional connectivity in posterior cingulate cortex of Parkinson's disease with mild cognitive impairment and dementia

Cited by 51 publications

References 33 publications

Functional Connectivity Signatures of Parkinson’s Disease

Functional Connectivity Signatures of Parkinson’s Disease

The Application of rs-fMRI in Vascular Cognitive Impairment

Resting‐state Functional MRI in Parkinsonian Syndromes

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