Abnormal resting-state functional connectivity of posterior cingulate cortex in amnestic type mild cognitive impairment

Bai, Feng; Watson, David; Yu, Hui; Shi, Yongmei; Yuan, Yonggui; Zhang, Zhijun

doi:10.1016/j.brainres.2009.09.028

Cited by 187 publications

(171 citation statements)

References 37 publications

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“…47 Hippocampal hypersynchrony with proximal regions and/or other regions of the DMN has been noted in risk groups for AD, including individuals positive for the apolipoprotein Ee4 allele [86][87][88] and mild cognitive impairment (MCI) patients 89,90 as well as individuals with early AD itself. 48 Similarly, increased resting-state connectivity between the PCC and other DMN regions has been noted in elderly individuals with elevated regional brain atrophy and memory complaints, 91 in MCI, 47,92,93 and in the very early stages of AD. 85,94,95 The concordance between the current results and those in neurodegenerative disease orients us to the potential consequences of TBIinduced network changes on long-term neurological status.…”

Section: Potential Markers Of Long-term Outcomementioning

confidence: 93%

Chronology and Chronicity of Altered Resting-State Functional Connectivity after Traumatic Brain Injury

Venkatesan

Dennis

Hillary

2015

Journal of Neurotrauma

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Whereas traumatic brain injury (TBI) results in widespread disruption of neural networks, changes in regional resting-state functional connectivity patterns after insult remain unclear. Specifically, little is known about the chronology of emergent connectivity alterations and whether they persist after a critical recovery window. We used resting-state functional magnetic resonance imaging and seed-voxel correlational analyses in both cross-sectional and longitudinal designs to probe intrinsic connectivity patterns involving the posterior cingulate cortex (PCC) and hippocampi, regions shown to be important in the default mode network (DMN) and vulnerable to neuropathology. A total of 22 participants in the chronic stage of moderateto-severe TBI and 18 healthy controls were included for cross-sectional study. Longitudinal analyses included 13 individuals in the TBI group for whom data approximately 3 months after injury (subacute) were available. Overall, results indicated dissociable connectivity trajectories of the PCC and hippocampi during recovery from TBI, with PCC alterations characterized by early hypersynchrony with the anterior DMN that is gradually reduced, and hippocampal changes marked by increasing synchrony with proximal cortex and subcortex. The PCC also showed increasing antiphase synchrony with posterior attentional regions, and the hippocampi showed decreasing antiphase synchrony with frontal attentional regions. Antiphase synchrony of the hippocampus and dorsolateral prefrontal cortex at the subacute stage of TBI was positively associated with attentional performance on neuropsychological tests at both the subacute and chronic stages. Our findings highlight the heterogeneity of regional whole-brain connectivity changes after TBI, and suggest that residual connectivity alterations exist in the clinically stable phase of TBI. Parallels between the chronicity of the observed effects and findings in neurodegenerative disease are discussed in the context of potential long-term outcomes of TBI.

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Section: Potential Markers Of Long-term Outcomementioning

confidence: 93%

Chronology and Chronicity of Altered Resting-State Functional Connectivity after Traumatic Brain Injury

Venkatesan

Dennis

Hillary

2015

Journal of Neurotrauma

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“…In mild AD patients, besides decreased connectivity in the DMN, the increased connectivity between the PCC and prefrontal regions were also found, which suggests the compensatoryrecruitment in early stage of AD ). The recruitment of compensatory mechanisms was further validated in aMCI, a syndrome that carries a high risk for developing AD, with the decreased connectivity between the PCC and the temporal cortex and the increased connectivity between the PCC and the regions in the frontal cortex in these patients (Bai et al 2009). While the PCu, a region adjacent to the PCC and also located in the DMN, was selected as seed region, the altered FC between the posterior and anterior portions of the DMN was found again (Sheline et al 2010).…”

Section: Spatial Pattern Analysismentioning

confidence: 99%

Spontaneous brain activity observed with functional magnetic resonance imaging as a potential biomarker in neuropsychiatric disorders

et al. 2010

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As functional magnetic resonance imaging (fMRI) studies have yielded increasing amounts of information about the brain's spontaneous activity, they have revealed fMRI's potential to locate changes in brain hemodynamics that are associated with neuropsychiatric disorders. In this paper, we review studies that support the notion that changes in brain spontaneous activity observed by fMRI can be used as potential biomarkers for diagnosis and treatment evaluation in neuropsychiatric disorders. We first review the methods used to study spontaneous activity from the perspectives of (1) the properties of local spontaneous activity, (2) the spatial pattern of spontaneous activity, and (3) the topological properties of brain networks. We also summarize the major findings associated with major neuropsychiatric disorders obtained using these methods. Then we review the pilot studies that have used spontaneous activity to discriminate patients from normal controls. Finally, we discuss current challenges and potential research directions to further elucidate the clinical use of spontaneous brain activity in neuropsychiatric disorders.

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“…Similarly, functional imaging studies reveal diminished intrinsic connectivity, the degree to which distributed brain structures fluctuate in synchrony in the absence of a structured task, in the default mode network in MCI and AD (18,19). The default mode network, which includes the medial temporal lobe, posterior cingulate cortex, precuneus, medial prefrontal cortex, and lateral temporoparietal cortex, supports various cognitive processes including episodic memory (20,21), a cognitive function that is particularly vulnerable in AD.…”

mentioning

confidence: 99%

Heightened emotional contagion in mild cognitive impairment and Alzheimer’s disease is associated with temporal lobe degeneration

Sturm

Yokoyama

Seeley

et al. 2013

Proc. Natl. Acad. Sci. U.S.A.

148

133

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Emotional changes are common in mild cognitive impairment (MCI) and Alzheimer's disease (AD). Intrinsic connectivity imaging studies suggest that default mode network degradation in AD is accompanied by the release of an emotion-relevant salience network. We investigated whether emotional contagion, an evolutionarily conserved affect-sharing mechanism, is higher in MCI and AD secondary to biological alterations in neural networks that support emotion. We measured emotional contagion in 237 participants (111 healthy controls, 62 patients with MCI, and 64 patients with AD) with the Interpersonal Reactivity Index Personal Distress subscale. Depressive symptoms were evaluated with the Geriatric Depression Scale. Participants underwent structural MRI, and voxel-based morphometry was used to relate whole-brain maps to emotional contagion. Analyses of covariance found significantly higher emotional contagion at each stage of disease progression [controls < MCI (P < 0.01) and MCI < AD (P < 0.001)]. Depressive symptoms were also higher in patients compared with controls [controls < MCI (P < 0.01) and controls < AD (P < 0.0001)]. Higher emotional contagion (but not depressive symptoms) was associated with smaller volume in right inferior, middle, and superior temporal gyri (P FWE < 0.05); right temporal pole, anterior hippocampus, parahippocampal gyrus; and left middle temporal gyrus (all P < 0.001, uncorrected). These findings suggest that in MCI and AD, neurodegeneration of temporal lobe structures important for affective signal detection and emotion inhibition are associated with up-regulation of emotion-generating mechanisms. Emotional contagion, a quantifiable index of empathic reactivity that is present in other species, may be a useful tool with which to study emotional alterations in animal models of AD.empathy | social behavior | simulation | affective resonance P rogressive deterioration of memory and other cognitive functions characterizes Alzheimer's disease (AD) (1) and its prodromal stage, mild cognitive impairment (MCI) (2). Deposition of beta-amyloid plaques and neurofibrillary tangles, the hallmark pathological changes in AD (3), is hypothesized to begin decades before the emergence of cognitive symptoms and subsequent functional decline (4). Emotional symptoms are also common and have been found in 35-85% of patients with MCI (5-7) and up to 75% of patients with AD (8), with depression and anxiety the most frequent symptoms seen. Individuals with MCI who have comorbid emotional complaints are more likely to progress to dementia than those without such symptoms (9-13). Taken together, these studies suggest that a clinical presentation that includes both cognitive decline and emotion dysregulation may point to an underlying AD process and that emotional symptoms themselves may portend or even exacerbate disease progression (9,11,14).The medial temporal lobe is among the earliest sites of disease in MCI and AD (2, 15), and hippocampal atrophy is associated with worse episodic memory performance on standardi...

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Abnormal resting-state functional connectivity of posterior cingulate cortex in amnestic type mild cognitive impairment

Cited by 187 publications

References 37 publications

Chronology and Chronicity of Altered Resting-State Functional Connectivity after Traumatic Brain Injury

Chronology and Chronicity of Altered Resting-State Functional Connectivity after Traumatic Brain Injury

Spontaneous brain activity observed with functional magnetic resonance imaging as a potential biomarker in neuropsychiatric disorders

Heightened emotional contagion in mild cognitive impairment and Alzheimer’s disease is associated with temporal lobe degeneration

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