Abnormal resting-state functional connectivity of hippocampal subfields in patients with major depressive disorder

Hao, Zi Yu; Zhong, Yuan; Ma, Zijuan; Xu, Hua; Kong, Jing; Wu, Zhou; Wu, Yun; Li, Jian; Lü, Xin; Zhang, Ning; Chün, Wang

doi:10.1186/s12888-020-02490-7

“…Molecular and cellular studies have examined the intracellular signaling pathways involved in the regulation of synaptic function by stress. Notably in the hippocampus, decreased neuroplasticity and synapse function in the dentate gyrus and CA sub-regions have been associated with causing depression-like behaviors (Law et al, 2016;Hao et al, 2020). Dendrites, for example, receive messages for the cell, allowing neurons to communicate with other neurons.…”

Section: Introductionmentioning

confidence: 99%

Chronic Anxiety- and Depression-Like Behaviors Are Associated With Glial-Driven Pathology Following Repeated Blast Induced Neurotrauma

Dickerson

¹

,

Murphy

²

,

Urban

³

et al. 2021

Front. Behav. Neurosci.

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Long-term neuropsychiatric impairments have become a growing concern following blast-related traumatic brain injury (bTBI) in active military personnel and Veterans. Neuropsychiatric impairments such as anxiety and depression are common comorbidities that Veterans report months, even years following injury. To understand these chronic behavioral outcomes following blast injury, there is a need to study the link between anxiety, depression, and neuropathology. The hippocampus and motor cortex (MC) have been regions of interest when studying cognitive deficits following blast exposure, but clinical studies of mood disorders such as major depressive disorder (MDD) report that these two regions also play a role in the manifestation of anxiety and depression. With anxiety and depression being common long-term outcomes following bTBI, it is imperative to study how chronic pathological changes within the hippocampus and/or MC due to blast contribute to the development of these psychiatric impairments. In this study, we exposed male rats to a repeated blast overpressure (~17 psi) and evaluated the chronic behavioral and pathological effects on the hippocampus and MC. Results demonstrated that the repeated blast exposure led to depression-like behaviors 36 weeks following injury, and anxiety-like behaviors 2-, and 52-weeks following injury. These behaviors were also correlated with astrocyte pathology (glial-fibrillary acid protein, GFAP) and dendritic alterations (Microtubule-Associated Proteins, MAP2) within the hippocampus and MC regions at 52 weeks. Overall, these findings support the premise that chronic glial pathological changes within the brain contribute to neuropsychiatric impairments following blast exposure.

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“…Thus, investigating reward processing in MDD may offer additional insight into how dysregulated reward networks may also contribute to substance use. Participants with MDD exhibit attenuated functional connectivity between the VS and cortical regions, such as the vmPFC and OFC (Furman et al, 2011;Hao et al, 2020). A meta-analysis of fMRI research assessing reward processing in MDD revealed distinct abnormalities within reward circuitry, such as a hyporesponsive ventral striatum and hyperresponsive OFC (Ng et al, 2019).…”

Section: Reward Hyposensitivity Modelmentioning

confidence: 99%

The Role of Social Reward and Corticostriatal Connectivity in Substance Use

Sazhin¹,

Frazier²,

Haynes³

et al. 2020

Preprint

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This report describes an ongoing R03 grant that explores the links between trait reward sensitivity, substance use, and neural responses to social and nonsocial reward. Although previous research has shown that trait reward sensitivity and neural responses to reward are linked to substance use, whether this relationship is impacted by how people process social stimuli remains unclear. We are investigating these questions via a neuroimaging study with college-aged participants, using individual difference measures that examine the relation between substance use, social context, and trait reward sensitivity with tasks that measure reward anticipation, strategic behavior, social reward consumption, and the influence of social context on reward processing. We predict that substance use will be tied to distinct patterns of striatal dysfunction. Specifically, reward hyposensitive individuals will exhibit blunted striatal responses to social and non-social reward and enhanced connectivity with the orbitofrontal cortex; in contrast, reward hypersensitive individuals will exhibit enhanced striatal responses to social and non-social reward and blunted connectivity with the orbitofrontal cortex. We also will examine the relation between self-reported reward sensitivity, substance use, and striatal responses to social reward and social context. We predict that individuals reporting the highest levels of substance use will show exaggerated striatal responses to social reward and social context, independent of self-reported reward sensitivity. Examining corticostriatal responses to reward processing will help characterize the relation between reward sensitivity, social context and substance use while providing a foundation for understanding risk factors and isolating neurocognitive mechanisms that may be targeted to increase the efficacy of interventions.

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“…Thus, investigating reward processing in MDD may offer additional insight into how dysregulated reward networks may also contribute to substance use. Participants with MDD exhibit attenuated functional connectivity between the VS and cortical regions, such as the vmPFC and OFC [ 33 , 34 ]. A meta-analysis of fMRI research assessing reward processing in MDD revealed distinct abnormalities within reward circuitry, such as a hyporesponsive ventral striatum and hyperresponsive OFC [ 35 ].…”

Section: Significancementioning

confidence: 99%

The Role of Social Reward and Corticostriatal Connectivity in Substance Use

Sazhin

¹

,

Frazier

²

,

Haynes

³

et al. 2020

J Psychiatry Brain Sci

View full text Add to dashboard Cite

This report describes an ongoing R03 grant that explores the links between trait reward sensitivity, substance use, and neural responses to social and nonsocial reward. Although previous research has shown that trait reward sensitivity and neural responses to reward are linked to substance use, whether this relationship is impacted by how people process social stimuli remains unclear. We are investigating these questions via a neuroimaging study with college-aged participants, using individual difference measures that examine the relation between substance use, social context, and trait reward sensitivity with tasks that measure reward anticipation, strategic behavior, social reward consumption, and the influence of social context on reward processing. We predict that substance use will be tied to distinct patterns of striatal dysfunction. Specifically, reward hyposensitive individuals will exhibit blunted striatal responses to social and non-social reward and enhanced connectivity with the orbitofrontal cortex; in contrast, reward hypersensitive individuals will exhibit enhanced striatal responses to social and non-social reward and blunted connectivity with the orbitofrontal cortex. We also will examine the relation between self-reported reward sensitivity, substance use, and striatal responses to social reward and social context. We predict that individuals reporting the highest levels of substance use will show exaggerated striatal responses to social reward and social context, independent of self-reported reward sensitivity. Examining corticostriatal responses to reward processing will help characterize the relation between reward sensitivity, social context and substance use while providing a foundation for understanding risk factors and isolating neurocognitive mechanisms that may be targeted to increase the efficacy of interventions.

show abstract

Abnormal resting-state functional connectivity of hippocampal subfields in patients with major depressive disorder

Cited by 35 publications

References 77 publications

Chronic Anxiety- and Depression-Like Behaviors Are Associated With Glial-Driven Pathology Following Repeated Blast Induced Neurotrauma

Chronic Anxiety- and Depression-Like Behaviors Are Associated With Glial-Driven Pathology Following Repeated Blast Induced Neurotrauma

The Role of Social Reward and Corticostriatal Connectivity in Substance Use

The Role of Social Reward and Corticostriatal Connectivity in Substance Use

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