Abnormal Retinal Function Associated With Fenretinide, a Synthetic Retinoid

Kaiser‐Kupfer, Muriel I.; Peck, Gary L.; Caruso, Rafael C.; Jaffe, Myles J.; DiGiovanna, John J.; Gross, Erhard

doi:10.1001/archopht.1986.01050130079024

Cited by 82 publications

(29 citation statements)

References 7 publications

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“…Initial clinical studies with 4-HPR at high doses (Kingston et al, 1986;Kaiser-Kupfer et al, 1986) were hampered by the fact that it has profound effects on the normal metabolism of vitamin A. It has been demonstrated that the regulation of RBP is greatly affected both in humans and experimental animals treated with 4-HPR (Formelli et al, 1987(Formelli et al, , 1989.…”

supporting

confidence: 41%

Secretion of N-(4-hydroxyphenyl) retinamide-retinol-binding protein from liver parenchymal cells: Evidence for reduced affinity of the complex for transthyretin

Holven¹,

Natarajan²,

Gundersen³

et al. 1997

Int. J. Cancer

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supporting

confidence: 41%

Secretion of N-(4-hydroxyphenyl) retinamide-retinol-binding protein from liver parenchymal cells: Evidence for reduced affinity of the complex for transthyretin

Holven¹,

Natarajan²,

Gundersen³

et al. 1997

Int. J. Cancer

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“…Treatment of Abca4 Ϫ/Ϫ mice, a model for such diseases, with FHR arrested accumulation of A2E and lipofuscin autofluorescence in the RPE by reducing ocular retinoid levels (28). An effect of FHR on ocular retinoid metabolism and visual performance also has been reported in patients treated with this drug to fight certain forms of cancer (41,42). As we show here, FHR acts by inducing Lrat-dependent cellular vitamin A uptake by non-ocular peripheral tissues, such as the lungs.…”

Section: Crbp1mentioning

confidence: 37%

Lecithin:Retinol Acyltransferase Is Critical for Cellular Uptake of Vitamin A from Serum Retinol-binding Protein

Amengual

Golczak

Palczewski

et al. 2012

Journal of Biological Chemistry

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Background: Cellular uptake of retinol bound to its serum binding protein depends on a cell surface receptor. Results: Functional coupling of this receptor with lecithin:retinol acyltransferase is required for the regulated cellular uptake of retinol. Conclusion:The lecithin: retinol acyltransferase is critical for retinol uptake and homeostasis. Significance: Blood retinol homeostasis is associated with blinding retinopathies and diabetes.

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“…12 This side effect seems to be due to insufficient supply of retinol to the eyes resulting from the displacement of retinol from serum RBP. [13][14][15]45 4-HPR exhibits extremely poor binding to nuclear retinoid receptors but not to RBP, and it shows anticancer activity against cells resistant to RA. 4-HPR may act on cells directly rather than through hydrolysis to free RA.…”

Section: Effects Of P-ddap On Plasma Retinol Concentrationmentioning

confidence: 43%

p‐Dodecylaminophenol derived from the synthetic retinoid, fenretinide: Antitumor efficacy in vitro and in vivo against human prostate cancer and mechanism of action

Takahashi

Watanabe

Maitani

et al. 2007

Intl Journal of Cancer

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Fenretinide, N‐(4‐hydroxyphenyl)retinamide (4‐HPR) is an aminophenol‐containing synthetic retinoid derivative of all‐trans‐retinoic acid, which is a potent chemopreventive and antiproliferative agent against various cancers. Clinical studies of 4‐HPR have shown side effects consisting of night blindness and ocular toxicity. To maintain potent anticancer activity without side effects, p‐dodecylaminophenol (p‐DDAP) was designed based on structure–activity relationships of 4‐HPR. In our study, we investigate whether p‐DDAP shows anticancer activity against human prostate cancer cell line PC‐3 when compared with 4‐HPR. p‐DDAP inhibited PC‐3 cell growth progressively from low to high concentration in a dose‐dependent manner. p‐DDAP was the most potent antiproliferative agent in vitro among 6 p‐alkylaminophenols and 3 4‐hydroxyphenyl analogs examined including 4‐HPR. Cells treated with p‐DDAP were shown to undergo apoptosis, based on condensation nuclei, cytofluorimetric analysis, propidium iodide staining and the expression of bcl‐2 and caspase 3. p‐DDAP arrested the S phase of the cell cycle, while 4‐HPR arrested the G0/G1 phase. In addition, both the i.v. and i.p. administration of p‐DDAP suppressed tumor growth in PC‐3‐implanted mice in vivo. p‐DDAP showed no effects on blood retinol concentrations, in contrast to reductions after 4‐HPR administration. These results indicate that p‐DDAP exhibits excellent anticancer efficacy against hormonal independent prostate cancer in vitro and in vivo, and it may have great potential for clinical use in the treatment of prostate cancer with reduced side effects. © 2007 Wiley‐Liss, Inc.

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Abnormal Retinal Function Associated With Fenretinide, a Synthetic Retinoid

Cited by 82 publications

References 7 publications

Secretion of N-(4-hydroxyphenyl) retinamide-retinol-binding protein from liver parenchymal cells: Evidence for reduced affinity of the complex for transthyretin

Secretion of N-(4-hydroxyphenyl) retinamide-retinol-binding protein from liver parenchymal cells: Evidence for reduced affinity of the complex for transthyretin

Lecithin:Retinol Acyltransferase Is Critical for Cellular Uptake of Vitamin A from Serum Retinol-binding Protein

p‐Dodecylaminophenol derived from the synthetic retinoid, fenretinide: Antitumor efficacy in vitro and in vivo against human prostate cancer and mechanism of action

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