Abnormal thyroid function predicts mortality in patients receiving long-term peritoneal dialysis: A case-controlled longitudinal study

Lin, Yong-Song; Lin, Yi Chun; Chen, Tzen Wen; Wu, Yang Chang; Lin, Chih Ching

doi:10.1016/j.jcma.2011.12.006

Cited by 14 publications

(11 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, decreased levels of active thyroid hormone is associated with outcomes of systemic infections (28). Therefore, the fact that prealbumin serves as a potent and effective carrier of thyroid hormone may also contribute to this association and explain why there remains a residual effect of prealbumin on predicting infectious outcomes even after adjusting for the effect of serum albumin concentration.…”

Section: Discussionmentioning

confidence: 99%

Prealbumin is Associated With Visceral Fat Mass in Patients Receiving Hemodialysis

Molfino

Heymsfield

Zhu

et al. 2013

Journal of Renal Nutrition

View full text Add to dashboard Cite

Objective Albumin and prealbumin are associated with nutritional status and inflammatory status. Each has a residual effect on mortality outcomes when included in regression models that include the other. Prealbumin is increased in the obese mouse model as a consequence of stabilization of prealbumin by Retinol Binding Protein 4 (RTB4), secreted by adipocytes. We carried out this study to establish the contribution of adiposity to prealbumin levels in prevalent dialysis patients and the relationship of prealbumin to RTB4. Design We determined whether prealbumin was associated with adiposity in hemodialysis (HD) patients, controlling for the effects of inflammation and nutrition. Subjects and Methods We evaluated body composition in 48 prevalent HD patients by magnetic resonance imaging (MRI), measuring total skeletal muscle mass (SM), visceral and subcutaneous adipose tissue (VAT and SAT), and serum albumin, prealbumin, RTB4, and interleukin-6 (IL-6). We used normalized protein catabolic rate (nPCR) to report nutrition and separately analyzed the determinants of albumin and then of prealbumin by multiple stepwise regression. Results Thirty two subjects were women, 16 were diabetic, median age and body mass index 54.5 and 27.3 kg/m2, respectively; median TAT 24.3 kg and VAT and 3.25 kg, respectively. Prealbumin was positively associated with VAT, nPCR and RTB4, and negatively associated with IL-6; r2 for the model 0.64. By contrast albumin was positively associated with nPCR and negatively with IL-6 but not with any measure of adiposity (r2 for the model = 0.2). Conclusions Prealbumin, like albumin, is associated with markers of nutrition (nPCR) and inflammation, but unlike albumin, prealbumin levels are positively associated with visceral adiposity.

show abstract

Section: Discussionmentioning

confidence: 99%

Prealbumin is Associated With Visceral Fat Mass in Patients Receiving Hemodialysis

Molfino

Heymsfield

Zhu

et al. 2013

Journal of Renal Nutrition

View full text Add to dashboard Cite

show abstract

“…Thyroid disorders including clinical and subclinical hypothyroidism in these patients can cause abnormalities in lipid metabolism, endothelial dysfunction, arterial stiffness, and inflammation contributing to the accelerated atherosclerosis and CVD (18)(19)(20)(21)(22). Similarly, data from clinical studies suggest that low levels of thyroid hormone may predict a higher risk of cardiovascular disease and overall mortality in patients with endstage renal disease (ESRD) undergoing dialysis (23,24). The causality of this association has not been elucidated and low thyroid hormone probably reflects an adaptive or maladaptive mechanism of chronic illness that characterizes CKD patients.…”

Section: Thyroid Disorders and Glomerular Filtration Ratementioning

confidence: 99%

“…CVD is highly prevalent before initiation of dialysis due to several cardiovascular risk factors such as hypertension, dyslipidemia, endothelial dysfunction, arterial stiffness, and accelerated atherosclerosis. There is clinical evidence that subclinical or primary hypothyroidism and low T3 syndrome are strongly associated with CVD and mortality in the general population and in CKD patients (18)(19)(20)(21)(22)(23)(24). …”

Section: Associations Of Thyroid Disorders With Ckd and Cvdmentioning

confidence: 99%

The Thyroid and the Kidney: A Complex Interplay in Health and Disease

et al. 2014

View full text Add to dashboard Cite

Thyroid hormones may directly affect the kidney and altered kidney function may also contribute to thyroid disorders. The renal manifestations of thyroid disorders are based on hemodynamic alterations or/and to direct effects of thyroid hormones. The renin-angiotensin system plays a crucial role in the cross-talk between the thyroid and the kidney. Hypothyroidism may be accompanied by an increase of serum creatinine and reduction of glomerular filtration rate (GFR), whereas hyperthyroidism may increase GFR. Treatment of thyroid disorders may lead to normalization of GFR. Primary and subclinical hypothyroidism and low triiodothyronine (T3) syndrome are common features in patients with chronic kidney disease (CKD). In addition low levels of thyroid hormones may predict a higher risk of cardiovascular and overall mortality in patients with end-stage renal disease. The causal nature of this correlation remains uncertain. In this review, special emphasis is given to the thyroid pathophysiology, its impact on kidney function and CKD and the interpretation of laboratorial findings of thyroid dysfunction in CKD.

show abstract

“…14 The major finding of this study was the presence of a mild thyroid dysfunction linked to an increased risk of mortality in long-term PD patients. The result confirmed previous findings.…”

mentioning

confidence: 75%

Abnormal thyroid function in peritoneal dialysis patients: Lots of smoke but no fire

Lin¹,

Tarng

2012

Journal of the Chinese Medical Association

View full text Add to dashboard Cite

Abnormal thyroid function predicts mortality in patients receiving long-term peritoneal dialysis: A case-controlled longitudinal study

Abstract: PD patients with abnormal thyroid function had poor cumulative survival. Lower thyroid hormone level in PD patients was associated with high CRP levels. Physicians should be alert for the presence of abnormal thyroid function and proinflammatory status in long-term PD patients.

Cited by 14 publications

References 26 publications

Prealbumin is Associated With Visceral Fat Mass in Patients Receiving Hemodialysis

Prealbumin is Associated With Visceral Fat Mass in Patients Receiving Hemodialysis

The Thyroid and the Kidney: A Complex Interplay in Health and Disease

Abnormal thyroid function in peritoneal dialysis patients: Lots of smoke but no fire

Contact Info

Product

Resources

About