Abnormal visual processing in migraine with aura: A study of steady-state visual evoked potentials

Shibata, Koichi; Yamane, Kiyomi; Otuka, Kuniaki; Iwata, Makoto

doi:10.1016/j.jns.2008.04.004

Cited by 45 publications

(51 citation statements)

References 66 publications

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“…Accordingly, the faster and smaller checksize stimulation by TVEP may play a crucial role in habituation behavior [14]. The present SSVEP study is in accordance with previous studies [30,35] that demonstrated greater migraine amplitude between attacks. Furthermore, the amplitude tended to increase depending on spatial frequency.…”

Section: Discussionsupporting

confidence: 92%

“…Fast Fourier transforms (FFTs) were used to MO migraine without aura, MA migraine with aura, HC healthy controls calculate amplitude (lV) for double the checkerboard reversal frequency of 7.5 Hz, i.e., the second harmonic response (2F = 15 Hz). According to our previous study on SSVEPs [30], because there were no significant phase differences between MO, MA, and HC, only the 2F amplitude was analyzed.…”

Section: Discussionmentioning

confidence: 99%

“…Generally, the response to higher spatial frequency preferentially stimulates the macular region, which has a much larger cortical representation, as opposed to lower spatial frequency that preferentially stimulates the periphery of the retina [36,37]. The increased response to higher spatial frequency could be explained by altered excitability of the visual cortex in migraine patients [30]. A number of studies have not observed consistent MA versus MO, or migraine versus control, amplitude differences [38][39][40][41][42][43].…”

Section: Discussionmentioning

confidence: 99%

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Spatial frequency differentially affects habituation in migraineurs: a steady-state visual-evoked potential study

et al. 2011

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A lack of habituation in visual-evoked potentials (VEPs) is the main abnormality observed in migraineurs. However, no study of steady-state VEPs has yet evaluated pattern-reversal stimuli with respect to habituation behavior or spatial frequency. The aim of this study was to clarify habituation behavior in migraineurs between attacks and to establish characteristics of VEPs in these patients. Steady-state VEPs were sequentially recorded as checkerboard patterns in four consecutive blocks from 12 patients with migraine without aura (MO), 12 patients with migraine with aura (MA), and 12 healthy controls (HC) at four spatial frequencies of 0.5, 1.0, 2.0, and 4.0 cycles per degree (cpd) with a stimulus rate of 7.5 Hz (15 reversal/s). VEP amplitudes were consistently higher in migraineurs. However, habituation was not demonstrated in HCs, and migraineurs did not reveal a clear lack of habituation. MAs exhibited high-amplitude VEPs, depending on spatial frequency. In the MA patients, amplitude differences reached statistical significance at 2.0 cpd. The sequential amplitude changes at 0.5 cpd were significantly different in MAs compared with HCs. Migraine patients exhibited high-amplitude VEPs, which were dependent on spatial frequency, and may be related to altered excitability in pre-cortical and cortical visual processing.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Spatial frequency differentially affects habituation in migraineurs: a steady-state visual-evoked potential study

et al. 2011

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“…14 Another group found an increased ampli tude of the second harmonic in both migraine groups, but an augmented amplitude of the fourth harmonic at high spatial frequency only in patients who had migraine with aura. 15 The investigators interpreted their results as reflecting increased responsivity of the primary visual cortex in both types of migraine, albeit with extension of this increased responsivity to include secondary visual areas in migraine with aura. This hypothesis is being further tested in studies of EEG mapping during intermittent visual stimulation, as described below.…”

Section: Eeg Changes Induced By Visual Stimulimentioning

confidence: 99%

“…The results have provided three main sets of observations, which were consistent across most studies. First, between attacks, a stimulus frequency dependent increase occurs in photic driving and synchronization of EEG alpha (8-13 Hz) and beta (13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30) rhythms. Second, the interictal migrain ous brain is characterized by a habituation (or adapta tion) deficit of cortical evoked responses to repetitive, non noxious sensory stimuli-this deficit normalizes during an attack.…”

Section: Introductionmentioning

confidence: 99%

Altered processing of sensory stimuli in patients with migraine

et al. 2014

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| Migraine is a cyclic disorder, in which functional and morphological brain changes fluctuate over time, culminating periodically in an attack. In the migrainous brain, temporal processing of external stimuli and sequential recruitment of neuronal networks are often dysfunctional. These changes reflect complex CNS dysfunction patterns. Assessment of multimodal evoked potentials and nociceptive reflex responses can reveal altered patterns of the brain's electrophysiological activity, thereby aiding our understanding of the pathophysiology of migraine. In this Review, we summarize the most important findings on temporal processing of evoked and reflex responses in migraine. Considering these data, we propose that thalamocortical dysrhythmia may be responsible for the altered synchronicity in migraine. To test this hypothesis in future research, electrophysiological recordings should be combined with neuroimaging studies so that the temporal patterns of sensory processing in patients with migraine can be correlated with the accompanying anatomical and functional changes.

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Optimal gamma‐band entrainment of visual cortex

Petro,

Webert,

Springer

et al. 2024

Human Brain Mapping

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Visual entrainment is a powerful and widely used research tool to study visual information processing in the brain. While many entrainment studies have focused on frequencies around 14–16 Hz, there is renewed interest in understanding visual entrainment at higher frequencies (e.g., gamma‐band entrainment). Notably, recent groundbreaking studies have demonstrated that gamma‐band visual entrainment at 40 Hz may have therapeutic effects in the context of Alzheimer's disease (AD) by stimulating specific neural ensembles, which utilize GABAergic signaling. Despite such promising findings, few studies have investigated the optimal parameters for gamma‐band visual entrainment. Herein, we examined whether visual stimulation at 32, 40, or 48 Hz produces optimal visual entrainment responses using high‐density magnetoencephalography (MEG). Our results indicated strong entrainment responses localizing to the primary visual cortex in each condition. Entrainment responses were stronger for 32 and 40 Hz relative to 48 Hz, indicating more robust synchronization of neural ensembles at these lower gamma‐band frequencies. In addition, 32 and 40 Hz entrainment responses showed typical patterns of habituation across trials, but this effect was absent for 48 Hz. Finally, connectivity between visual cortex and parietal and prefrontal cortices tended to be strongest for 40 relative to 32 and 48 Hz entrainment. These results suggest that neural ensembles in the visual cortex may resonate at around 32 and 40 Hz and thus entrain more readily to photic stimulation at these frequencies. Emerging AD therapies, which have focused on 40 Hz entrainment to date, may be more effective at lower relative to higher gamma frequencies, although additional work in clinical populations is needed to confirm these findings.Practitioner Points Gamma‐band visual entrainment has emerged as a therapeutic approach for eliminating amyloid in Alzheimer's disease, but its optimal parameters are unknown. We found stronger entrainment at 32 and 40 Hz compared to 48 Hz, suggesting neural ensembles prefer to resonate around these relatively lower gamma‐band frequencies. These findings may inform the development and refinement of innovative AD therapies and the study of GABAergic visual cortical functions.

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Abnormal visual processing in migraine with aura: A study of steady-state visual evoked potentials

Cited by 45 publications

References 66 publications

Spatial frequency differentially affects habituation in migraineurs: a steady-state visual-evoked potential study

Spatial frequency differentially affects habituation in migraineurs: a steady-state visual-evoked potential study

Altered processing of sensory stimuli in patients with migraine

Optimal gamma‐band entrainment of visual cortex

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