It is a challenge to research and develop silicon surfactants with good acid and alkali stability. In the present paper, methylpropenyl polyether modified nonionic silicone surfactant (MPNTS), an alkali-resistant and hydrolysis-resistant silicone surfactant, was synthesized by hydrosilylation of 1,1,1,3,5,5,5-heptamethyl trisiloxane (MDHM) and methylpropenyl polyether (EO(7)). The polyether segments are grafted onto the main chain of organosilicon heptamethyl trisiloxane at a molar ratio of 1:1.05 (n(Si-H):n(C=C)). To evidence product formation, the MPNTS were analyzed by FT-IR and 1H NMR spectroscopy. The surface tension of NPNTS is 18.68 mN/m, and the CMC value is 78 mg/L by a contact angle tester. MPTNS shows hydrolytic stability and maintains that it could keep surface activity after standing for 60 days at pH = 7–10. The compatibility performance analysis shows that MPNTS has good compatibility and synergy with cationic, anionic, and nonionic surfactants, and it reveals the application prospects in daily chemicals, agricultural adjuvants, and other products.