Abnormal within- and cross-networks functional connectivity in different outcomes of herpes zoster patients

Wu, Ying; Wang, Chao; Lu, Yu; Qian, Wei; Xing, Xiufang; Zhang, Minming; Yan, Min

doi:10.1007/s11682-021-00510-y

Cited by 6 publications

(6 citation statements)

References 87 publications

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“…In State 1, we observed an increase in dFC between the BGN and SN in HZ patients compared to HCs, which similar to the results of a previous study on functional connectivity in resting states [27]. The BGN receives pain input from different cortical regions, such as the anterior cingulate gyrus, the core node of the SN, and projects it through the thalamus to the cortex, forming the BG-thalamo-cortex circuit [28].…”

Section: Discussionsupporting

confidence: 87%

Altered dynamic functional network connectivity in herpes zoster patients and postherpetic neuralgia patients

Lv,

Jiang,

et al. 2024

Preprint

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Postherpetic neuralgia (PHN) is a neuropathic pain syndrome characterized by persistent burning or stinging pain, and its underlying pathogenesis is still unclear. Although conventional resting-state magnetic resonance imaging (rs-fMRI) studies have revealed abnormal resting-state functional connectivity (rsFC) in PHN patients, dynamic functional connectivity (dFC) remains unexplored. In this paper, a sliding time window method was used to generate a dFC matrix, and rs-fMRI data from 55 PHN patients, 55 Herpes Zoster (HZ) patients, and 50 healthy controls (HCs) were analyzed. Machine learning was used to determine whether these abnormal dFC values could be used as neuroimaging markers of the transition from HZ to PHN. All dFC matrices were clustered into two reoccurring states, and the state transition metrics were obtained. We found that patients with PHN were in State 1, which is characterized by weak connections between the networks, more often than patients with HZ (p < 0.05). We also found that in State 1, compared with that in HCs, the dFC between the BGN and SN in HZ patients increased. In State 2, the dFC of PHN patients was lower than that of HZ patients and HCs, and the dFC was mainly observed in the DMN, SN, DAN, VN and LN. The results of the SVM classifier revealed that the change in dFC between the BGN and DMN may be a strong neuroimaging marker of the transition from HZ to PHN. These findings further our understanding of the neuropathological mechanism of PHN.

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Section: Discussionsupporting

confidence: 87%

Altered dynamic functional network connectivity in herpes zoster patients and postherpetic neuralgia patients

Lv,

Jiang,

et al. 2024

Preprint

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“…PHN has been characterized by abnormalities within default mode network (DMN), DMN-salience network (SN), and SN-basal ganglia network connectivity relative to healthy controls. Available data argue for an acquired network-level imbalance in PHN [45].…”

Section: Complications 61 Postherpetic Neuralgiamentioning

confidence: 99%

Herpes zoster: A Review of Clinical Manifestations and Management

Patil

Goldust

Wollina

2022

Viruses

216

123

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The Varicella-zoster virus (VZV) or human herpes virus 3 is a neurotropic human alpha herpes virus responsible for chickenpox/varicella and shingles/herpes zoster (HZ). This review will focus on HZ. Since HZ is secondary to varicella, its incidence increases with age. In children and youngsters, HZ is rare and associated to metabolic and neoplastic disorders. In adults, advanced age, distress, other infections (such as AIDS or COVID-19), and immunosuppression are the most common risk factors. HZ reactivation has recently been observed after COVID-19 vaccination. The disease shows different clinical stages of variable clinical manifestations. Some of the manifestations bear a higher risk of complications. Among the possible complications, postherpetic neuralgia, a chronic pain disease, is one of the most frequent. HZ vasculitis is associated with morbidity and mortality. Renal and gastrointestinal complications have been reported. The cornerstone of treatment is early intervention with acyclovir or brivudine. Second-line treatments are available. Pain management is essential. For (secondary) prophylaxis, currently two HZV vaccines are available for healthy older adults, a live attenuated VZV vaccine and a recombinant adjuvanted VZV glycoprotein E subunit vaccine. The latter allows vaccination also in severely immunosuppressed patients. This review focuses on manifestations of HZ and its management. Although several articles have been published on HZ, the literature continues to evolve, especially in regard to patients with comorbidities and immunocompromised patients. VZV reactivation has also emerged as an important point of discussion during the COVID-19 pandemic, especially after vaccination. The objective of this review is to discuss current updates related to clinical presentations, complications, and management of HZ.

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“…We computed four parameters of network properties, which were based on the constructed PLV weighted matrix, including clustering coefficient, shortest path length, global efficiency, and local efficiency. Compared with the HC group, the clustering coefficient and the local efficiency of HZ patients decreased in full band (1-45 Hz) and the clustering coefficient, the global efficiency, and the local efficiency of HZ patients group decreased in beta band (13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30). The shortest path length, however, increased in HZs in this band (Figure 1B and C).…”

Section: Network Propertiesmentioning

confidence: 91%

“…[12][13][14][15][16] Some studies using functional magnetic resonance imaging (fMRI) have found altered functional networks patients with peripheral HZ, which may indicate that the pain processing in HZ patients were different from normal subjects. 17,18 These studies on HZ are biologically meaningful considering that their findings may provide new understandings on the multiple dimensions of pain processing. However, few studies concentrated on brain function changes and pain modulation mechanisms in patients with acute HZ using EEG.…”

Section: Introductionmentioning

confidence: 98%