Abnormalities in leukocyte morphology and number

Zini, Gina

doi:10.1016/b978-0-7020-3147-2.00016-x

Cited by 13 publications

(7 citation statements)

References 94 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although several research groups have reported many clinical anomalies associated with the unfavorable progression of COVID-19, such as increases in lactate dehydrogenase, alanine aminotransferase, aspartate aminotransferase, bilirubin, creatinine, cardiac Viruses 2021, 13, 1675 2 of 16 troponin, D-dimers, procalcitonin, and C-reactive protein (CRP) [3][4][5][6], a high neutrophil-tolymphocyte ratio (NLR) has received special attention [5,7,8]. The behavior of eosinophils in a state of eosinopenia (i.e., a reduction in circulating eosinophils < 0.01 × 10 9 /L) [9], as has previously been described in response to systemic inflammation [10,11], has also been highlighted in COVID-19 [3,[12][13][14][15][16][17].…”

Section: Introductionmentioning

confidence: 99%

“…Eosinophils are leukocytes involved in allergic diseases and host protection against parasites through the release of cytokines/chemokines, mediators, antimicrobial peptides, eosinophil extracellular traps (EETs), and cytotoxic granule cationic proteins, such as major basic protein (MBP), eosinophil peroxidase (EPO), eosinophil cationic protein (ECP), and eosinophil-derived neurotoxin (EDN) (7)(8)(9). In addition to the proinflammatory effects of eosinophils, evidence in mice has indicated that eosinophils play important roles as regulatory cells involved in protective immunity and antiviral responses [18][19][20][21][22].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Behavior of Eosinophil Counts in Recovered and Deceased COVID-19 Patients over the Course of the Disease

Cortés-Vieyra

Gutiérrez-Castellanos

Álvarez-Aguilar

et al. 2021

Viruses

View full text Add to dashboard Cite

Knowledge about the immune responses against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, particularly regarding the function of eosinophils, has been steadily emerging recently. There exists controversy regarding the implications of eosinophils in the coronavirus disease 2019 (COVID-19)’s pathology. We report a retrospective cohort study including the comparison of leukocyte counts in COVID-19 patients, considering the outcomes of recovery (n = 59) and death (n = 60). Among the different types of leukocytes, the eosinophil counts were those that showed the greatest difference between recovered and deceased patients. Eosinopenia (eosinophil count < 0.01 × 109/L) was more frequently observed in deceased than recovered patients (p = 0.0012). The eosinophil counts more rapidly increased and showed a greater proportion over the course of the disease in the recovered than deceased patients. Furthermore, the estimated survival rate was greater in patients without eosinopenia than in patients with eosinopenia (p = 0.0070) during hospitalization. Importantly, recovered but not deceased patients showed high negative correlations of the eosinophils with the neutrophil-to-lymphocyte ratio (NLR) and neutrophil counts at Day 9 of the onset of clinical symptoms (p ≤ 0.0220). Our analysis suggests that eosinopenia may be associated with unfavorable disease outcomes and that the eosinophils have a beneficial function in COVID-19 patients, probably contributing by controlling the exacerbated inflammation induced by neutrophils.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Behavior of Eosinophil Counts in Recovered and Deceased COVID-19 Patients over the Course of the Disease

Cortés-Vieyra

Gutiérrez-Castellanos

Álvarez-Aguilar

et al. 2021

Viruses

View full text Add to dashboard Cite

show abstract

“…has been described for more than 6 decades. Patients with CS may present leukocytosis and neutrophilia and a low lymphocyte and eosinophil count or eosinopenia [9,23,24]. In the absence of exogenous corticosteroid use, eosinopenia would be the most specific laboratory finding.…”

Section: Discussionmentioning

confidence: 99%

“…In physiological conditions, during acute stress, eosinopenia is mediated by adrenal glucocorticoids and epinephrine. In patients treated with corticosteroids, eosinopenia would result from an impairment in the release of these cells from the bone marrow and its sequestration of the blood pool [9]. Chronic hypercortisolemia in CS can explain this typical finding which should be taken into account when evaluating a suspected case.…”

Section: Introductionmentioning

confidence: 99%

Combination of High Prevalence Sign/Symptom Pairs: An Approach to the Diagnosis of Cushing’s Syndrome

Araya¹,

Liberman²,

Munizaga³

et al. 2024

Adrenal Glands - The Current Stage and New Perspectives of Diseases and Treatment

View full text Add to dashboard Cite

Most of the clinical features of Cushing’s syndrome (CS) are nonspecific and could be present in obesity, particularly when this condition is associated with metabolic syndrome. Our objective was to evaluate the frequency of clinical manifestations and changes in general laboratory tests, in patients with confirmed endogenous CS, to identify diagnostic dyads. We evaluated in each patient the rate of coexistence of 2 elements either: symptoms, clinical signs, or laboratory alteration. The prevalence of a combined pair of clinical features or dyad in over 30% of the cases, was considered clinically significant. Fourteen dyads were identified as clinically relevant. Facies + buffalo hump; facies + eosinopenia; buffalo hump + supraclavicular fat pads and facies + supraclavicular fat pads, were present in over 50% of cases. Facies + muscular atrophy; centripetal fat distribution + muscular atrophy and facies + striae were present in 42–49%. Hirsutism/acne + eosinopenia; buffalo hump + eosinopenia; muscular atrophy+ eosinopenia; eosinopenia + accelerated weight gain; buffalo hump + muscular atrophy; hirsutism/acne + muscular atrophy and hirsutism/acne + supraclavicular fat pads, were observed in 33–38% of patients. Its application will facilitate the correct diagnosis of CS.

show abstract

“…3 Pseudo -Pelger Huet anomaly has similar morphology but different aetiology like Myelodysplastic syndrome, infections, drugs etc. 3 The cause is mutations of the Lamin B receptor (LBR) gene, 4,5 which is important for maintaining nuclear structure. Bone Marrow in homozygote shows normal morphologic maturation.…”

Section: How To Cite This Articlementioning

confidence: 99%

Study of Neutrophil Nuclear Lobulations on Peripheral Blood Smears and Distinguishing the Bilobed Neutrophils From Pelger Huet Cells

Barpande¹,

Gaopande²,

Joshi³

2018

jebmh

View full text Add to dashboard Cite

BACKGROUND Myeloid cells in the peripheral blood are classified into neutrophils, eosinophils and basophils depending on the staining characteristics of the cytoplasmic granules. 1 Neutrophils are lobulated granulocytes. The mature human neutrophil, unlike most other cells exhibits a distinctly non-spherical nucleus, which is segmented into three to five lobes. 2 MATERIALS AND METHODS A prospective study of 1000 Peripheral Blood Smears (PBS) was undertaken. The EDTA venous sample was run on cell counter. NDC was calculated, the data was tabulated and analysed statistically. RESULTS All smears showed bilobed neutrophils. Maximum (89.9%) smears showed 11-30 % bilobed neutrophils in their smears. Classical Pince-Nez nuclear morphology was found in 808 cases (80.8%) (Pince-Nez morphology-two well defined symmetrical lobes connected with thin strand of nuclear material). CONCLUSION The pince-nez morphology is frequent in neutrophils. Detecting rod like, dumb-bell shapes, peanut shaped nuclei are more diagnostic of PHA/PPHA. Important distinguishing features are smooth outline of nuclear lobes and coarseness of chromatin.

show abstract

Abnormalities in leukocyte morphology and number

Cited by 13 publications

References 94 publications

Behavior of Eosinophil Counts in Recovered and Deceased COVID-19 Patients over the Course of the Disease

Behavior of Eosinophil Counts in Recovered and Deceased COVID-19 Patients over the Course of the Disease

Combination of High Prevalence Sign/Symptom Pairs: An Approach to the Diagnosis of Cushing’s Syndrome

Study of Neutrophil Nuclear Lobulations on Peripheral Blood Smears and Distinguishing the Bilobed Neutrophils From Pelger Huet Cells

Contact Info

Product

Resources

About