Abnormalities in serum osteocalcin values in children with chronic rheumatic diseases

Reed, Ann M.; Haugen, Maureen; Pachman, Lauren M.; Langman, Craig B.

doi:10.1016/s0022-3476(05)81605-1

Cited by 92 publications

(48 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Osteocalcin levels tended to be lower in pediatricage SLE patients than in controls, a finding reported in previous studies of children with rheumatic diseases (47) and in adults with SLE (11,40). Reduced osteoblast function and increased bone resorption are also known to be effects of corticosteroids (21,48,49).…”

Section: Osteopenia In Patients With Childhood-onset Slesupporting

confidence: 58%

Frequency of osteopenia in children and young adults with childhood‐onset systemic lupus erythematosus

Lilleby¹,

Lien²,

Frøslie³

et al. 2005

Arthritis & Rheumatism

View full text Add to dashboard Cite

Objective. To determine the frequency of osteopenia in patients with childhood-onset systemic lupus erythematosus (SLE) compared with that in healthy matched controls, and to evaluate the relationship between disease-related variables and bone mineral mass.Methods. Bone mineral density (BMD) and bone mineral content (BMC) were measured in a cohort of 70 patients with childhood-onset SLE (mean ؎ SD disease duration 10.8 ؎ 8.3 years, mean ؎ SD age 26.4 ؎ 9.9 years) and 70 age-and sex-matched healthy controls. BMD and BMC of the femoral neck, lumbar spine, total body, and distal one-third of the radius were measured by dual x-ray absorptiometry. We investigated the relationship between BMC and the following disease variables: cumulative dose of corticosteroids, organ damage, current use of corticosteroids, use of cyclophosphamide, age at disease onset, and disease activity at the time of diagnosis. Biochemical markers of bone metabolism were also measured.Results. BMD values for the lumbar spine and femoral neck were significantly lower in patients than in healthy controls. The reduction in BMD of the lumbar spine was significantly greater than that of the total body. In multiple linear regression analyses, a higher cumulative corticosteroid dose was significantly associated with lower BMC of the lumbar spine and femoral neck. Decreased lumbar spine BMC was also related to male sex.Conclusion. The frequency of osteopenia was higher in patients with childhood-onset SLE than in matched controls. The lumbar spine was the most seriously affected skeletal site, followed by the femoral neck. The cumulative dose of corticosteroids was shown to be an important explanatory variable for BMC values in the lumbar spine and femoral neck.

show abstract

Section: Osteopenia In Patients With Childhood-onset Slesupporting

confidence: 58%

Frequency of osteopenia in children and young adults with childhood‐onset systemic lupus erythematosus

Lilleby¹,

Lien²,

Frøslie³

et al. 2005

Arthritis & Rheumatism

View full text Add to dashboard Cite

show abstract

“…It can cause osteopenia in children patients with malignancies, but low-dose methotrexate used in inflammatory diseases did not influence negatively the bone mass [27,28]. No relation was found with BMD and Methotrexate use in present study.…”

Section: Discussioncontrasting

confidence: 50%

“…On the other hand the low bone mass is associated with the high activity of the disease and with the number of involved joints in JIA patients also with the reduction of bone formation [21,22]. In our study we didn't find any correlation between ESR, disease activity, disease duration, DAS 28, CHAQ and BMD.Children with JIA have to take many medications, such corticosteroids that have significant effects on bone and its mineralization [10,8,23]. In our sample, the loss of bone mass appears to be associated with cumulative dose of corticosteroids.…”

mentioning

confidence: 57%

“…Several studies (mainly cross-sectional) have demonstrated reduced BMD or bone mineral content (BMC) in children and adolescents with JIA [6]. The precise mechanisms that JIA produce osteopenia in these children are not completely understood [7,8]. Previous studies have shown that osteoporosis in JIA has a multifactorial origin [8][9][10].…”

Section: Introductionmentioning

confidence: 99%

“…The precise mechanisms that JIA produce osteopenia in these children are not completely understood [7,8]. Previous studies have shown that osteoporosis in JIA has a multifactorial origin [8][9][10]. Reduced or absent physical activity, decreased production of endogenous vitamin D and drug treatment, especially steroid treatment, are thought to be possible mechanisms of osteoporosis in children with JIA [7][8][9].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Bone Mineral Density in Moroccan Patients with Juvenile Idiopathic Arthritis

Badri¹,

Rostom²,

Bouaddi³

et al. 2014

J Arthritis

View full text Add to dashboard Cite

Aim: The aim of this study was to evaluate the bone mineral density (BMD) in Moroccan patients with juvenile idiopathic arthritis and its correlates with disease parameters and vitamin D status.Methods: Forty patients with juvenile idiopathic arthritis (JIA) were included in a cross-sectional study. The diagnosis of JIA was made according to the criteria of the International League of Association of Rheumatology (ILAR). Information on disease activity, quality of life, sex, age, age at diagnosis, duration of medication use and bone fractures were collected by use of a standardized questionnaire. Patients underwent anthropometric assessment, puberty staging and BMD assessment by dual energy X-ray absorptiometry of the lumbar spine, and total body. Bone mineral density (in g/cm 2 ) was expressed in Z-scores, the number of standard deviation above or below the mean value of an age-and sex-matched reference population. In children, low BMD was defined as a Z-score less than -2 and osteoporosis was defined as a Z-score less than-2 with a fracture history. The daily intake of calcium was determined by the translated version in Moroccan Arabic language of Fardellone questionnaire. Laboratory evaluations included serum calcium, phosphate, alkaline phosphatase, 25-hydroxyvitamin D were assessed.Results: Forty children with JIA were included (22 male, 18 female); the mean of age of the patients was 11 ± 4.23 years. The median of disease duration was 2 years [1][2][3][4][5]. Eighteen (45%) patients had polyarticular JIA and 60% used corticosteroids.Twenty patients (50%) were given a diagnosis of low BMD and no patient was given a diagnosis of osteoporosis. Bone mineral density Z score in lumbar spine showed a statistically significant correlation with cumulative dose of corticosteroids (β=-0.40, p=0.05) and systemic subtype of JIA (β=-1.07, p=0.01) and the BMD in total body showed a statistically significant correlation with weight (β=0.40, p=0.009) and height (β=0.37, p=0.01). However, there was no significant association in our study between the BMD and disease duration, daily intake of calcium, and 25-hydroxyvitamin D. Conclusion:This study suggests that osteopenia was a frequent complication of JIA and it was associated to systemic subtype of JIA, height and cumulative dose of corticosteroids.Citation: El Badri D, Rostom S, Bouaddi I, Hassani A, Chkirate B, et al. (2014) Height and weight of the children were measured and recorded by the same observer using the same measurement device and height standard deviation score (Height SDS=Measured height-Normal height for age and sex/Standard deviation) and body mass index [BMI=Body weight (kg)/Height 2 (m 2 )] were calculated.The puberty status (pre-or postpubertal) was determined by using Tanner stage (from 1 to 5). The daily intake of calcium was determined by Fardellone questionnaire [14] translated and validated into Arabic language.The disease activity was scored using the tender and swollen joint counts, disease activity score (DAS 28) [15] for polyarticular a...

show abstract

Evolution of latent hypoparathyroidism in familial 22q11 deletion syndrome

et al. 1997

Self Cite

View full text Add to dashboard Cite

Latent hypoparathyroidism (LHP), the inability to increase midmolecular parathyroid hormone levels appropriately during a hypocalcemic challenge, was reported previously in an asymptomatic woman with tetralogy of Fallot. This women's fourth child died with DiGeorge anomaly. Seven years later, we restudied the index patient with LHP and evaluated three generations of her family for parathyroid dysfunction, cardiac abnormalities, and del 22(q11). Deletions were found in six relatives, three with conotruncal cardiac defects and three with a structurally normal heart. We found significant transgenerational noncardiac phenotypic variability, including learning difficulties, dysmorphic facial appearance, and psychiatric illness. A spectrum of parathyroid gland dysfunction associated with the del 22(q11) was seen, ranging from hypocalcemic hypoparathyroidism to normocalcemia with abnormally low basal intact parathyroid hormone (iPTH) levels. In addition, LHP found in the index patient 7 years ago had evolved to frank hypocalcemic hypoparathyroidism. In this family, which is the largest family with 22q11 deletions studied to date, parathyroid gland dysfunction evolved over time. We suggest that the calcium parathyroid hormone axis of unrelated patients with del 22(q11) be followed closely for the development of hypocalcemic hypoparathyroidism.

show abstract

Abnormalities in serum osteocalcin values in children with chronic rheumatic diseases

Cited by 92 publications

References 32 publications

Frequency of osteopenia in children and young adults with childhood‐onset systemic lupus erythematosus

Frequency of osteopenia in children and young adults with childhood‐onset systemic lupus erythematosus

Bone Mineral Density in Moroccan Patients with Juvenile Idiopathic Arthritis

Evolution of latent hypoparathyroidism in familial 22q11 deletion syndrome

Contact Info

Product

Resources

About