Abnormalities in Thyroid Function in Relatives of Patients with Graves' Disease and Hashimoto's Thyroiditis: Lack of Correlation with Inheritance of HLA-B8

Chopra, Inder J.; Chopra, Usha; Yoshihara, Emi; Terasaki, Paul I.; Smith, Franklin R.

doi:10.1210/jcem-45-1-45

Cited by 82 publications

(18 citation statements)

References 19 publications

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“…Recent studies on HLA antigens have also suggested a genetic hetero¬ geneity of autoimmune thyroiditis. Graves' thyrotoxicosis and primary myxoedema are associated with tissue antigens HLA-B8 whereas no such relation has been shown for (goitrous) Hashimoto's thyroiditis (Chopra et al 1977). Only the study of Moens & Farid (1978) reported an association with HLA-DRw3, but the criteria for selection of their patients included both the atrophie and the hypertrophic variants.…”

Section: Discussionmentioning

confidence: 99%

Immunological and clinical characterization of patients with untreated euthyroid and hypothyroid autoimmune thyroiditis. Antibody spectrum, response to TRH and clinical study

Scherbaum

Stöckle

Wichmann

et al. 1982

Acta Endocrinologica

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In a region of endemic goitres, 200 untreated patients in whom thyroid microsomal (MCHA) and/or thyroglobulin (TGHA) antibodies have been detected were analyzed and other organ specific autoantibodies were tested. Thyroid function was assessed by a TRH test in all of them. Patients with previous thyroid disease and patients with clinical or biochemical signs of thyrotoxicosis were excluded.In 58 (29%) of the patients diseases coexisted in which a high incidence of autoimmune reactions has been recognized. In the absence of the corresponding clinical disease, 13.7% of the patients had antibodies to parietal cells of the stomach, 3.1% had antibodies to adrenal cortex, 1% to steroid producing gonadal cells, 1% to pancreatic islet cells, and 0.5% of the patients had antibodies to striated muscle fibrils. The incidence of associated organ-specific autoantibodies was no higher in patients with hypothyroidism (36.4%) compared with patients who had a normal thyroid function (27.9%). The determination of a 'significant' thyroid antibody titre is discussed.In 24.5% of the 200 patients a form of hypothyroidism was recognized. Fifty of the patients with TGHA titres \m=ge\6400, and 56.2% of those with MCHA \m=ge\102400 were hypothyroid. Patients with such titres of thyroid antibodies should be examined and followed up. Patients with associated islet cell or adrenal antibodies should be reinvestigated and followed up observing their glucose tolerance and adrenocortical function, respectively. Autoimmune thyroid disease implies a great spec¬ trum of clinical conditions, including (goitrous) Hashimoto's disease, primary myxoedema, and

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Section: Discussionmentioning

confidence: 99%

Immunological and clinical characterization of patients with untreated euthyroid and hypothyroid autoimmune thyroiditis. Antibody spectrum, response to TRH and clinical study

Scherbaum

Stöckle

Wichmann

et al. 1982

Acta Endocrinologica

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“…It has therefore been proposed that endo¬ crine exophthalmos and the hyperthyroidism of Graves' disease are separate autoimmune disorders (Munro et al 1973;Volpé et al 1974;O'Donell et al 1978;Chopra et al 1977;Solomon et al 1977;Teng et al 1977;Wall et al 1979), the concomi¬ tance being due to an underlying deficient sup¬ pressor T-cell function (Doniach & Florin-Christensen 1975). In addition the changed humoral immunological state of the exophthalmos could be expressed only locally ).…”

Section: Discussionmentioning

confidence: 99%

Serum thyroglobulin, its autoantibody and thyroid stimulating antibodies in the endocrine exophthalmos

Rasmussen

Kemp

Bech

et al. 1981

Acta Endocrinologica

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Serum concentrations of thyroglobulin, its antibody, and thyroid stimulating antibodies were studied in 32 patients referred to a department of eye\ x=r eq-\ diseases for exophthalmos. Twenty-three of the patients were or had been medically treated for Graves' disease, one had toxic nodular goitre, one subclinical myxoedema, three euthyroid exophthalmos and four were shown to have non-endocrine eye-disease. In patients with medically treated Graves' disease serum thyroglobulin was significantly elevated (P < 0.02), the still toxic patients accounting for the highest values. Both thyroid stimulating and thyroglobulin antibodies were detectable in 4 of 18 patients. The rest of the patients had normal concentrations of thyroglobulin and undetectable thyroid stimulating antibodies, but 3 patients had measurable thyroglobulin antibodies. In Graves' patients there was no correlation between serum concentrations of thyroid stimulating antibodies and thyroglobulin, and no clear difference between the frequency of thyroid stimulating or thyroglobulin antibodies in the patients with persistent elevation of circulating thyroid hormones and those remaining euthyroid. A relation between the thyroid autoantibodies, thyroglobulin and the thyroid hormonal level or severity of the exophthalmic state could not be demonstrated.

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“…LATS assays were positive in 2 of 95 children with Graves' disease and in 1 of 49 control children; none of 40 Graves' children had detectable TSH receptor antibody by TBII (not including 3 subjects who had previous or concurrent thyrotoxicosis). Chopra et al (286) in 1977 noted a 3.8% incidence of LATS protector in Graves' disease relatives while 11% had goiter, 34% had thyroid antibodies, and 5% had elevated serum TSH levels.…”

Section: Specificity Of Tsh Receptor Antibodies For Graves' Diseasementioning

confidence: 99%

“…It is known that relatives of Graves' patients may have immunologic abnormalities: about 25% may have positive LATS levels; some patients may have abnormal thyroid function tests, TRH stimulation tests, and/or T 3 suppression tests (283)(284)(285)(286)(287)(288)(289)(290). Wall et al in 1969 (284), reported the prevalence of TSH receptor antibodies in relatives of Graves' disease patients was 23%.…”

Section: Specificity Of Tsh Receptor Antibodies For Graves' Diseasementioning

confidence: 99%

Immune Mechanisms In Graves' Disease

1985

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Abnormalities in Thyroid Function in Relatives of Patients with Graves' Disease and Hashimoto's Thyroiditis: Lack of Correlation with Inheritance of HLA-B8

Cited by 82 publications

References 19 publications

Immunological and clinical characterization of patients with untreated euthyroid and hypothyroid autoimmune thyroiditis. Antibody spectrum, response to TRH and clinical study

Immunological and clinical characterization of patients with untreated euthyroid and hypothyroid autoimmune thyroiditis. Antibody spectrum, response to TRH and clinical study

Serum thyroglobulin, its autoantibody and thyroid stimulating antibodies in the endocrine exophthalmos

Immune Mechanisms In Graves' Disease

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