Abnormalities of Calcium Deposition in Diabetes Mellitus

Root, Howard F.

doi:10.1001/archinte.1934.00160070051004

Cited by 9 publications

(4 citation statements)

References 12 publications

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“…Following earlier (4,5,6,7,8,9) suggestions of an increased prevalence of fractures in T1DM, the results of the Iowa Women's Health Study, an 11-year follow-up of 32 089 postmenopausal women, were reported in 2001 (18). Hip fractures were found to be 12 times more common in women with T1DM compared to matched controls.…”

Section: Fracture Riskmentioning

confidence: 90%

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MECHANISMS IN ENDOCRINOLOGY: Mechanisms and evaluation of bone fragility in type 1 diabetes mellitus

Hough

Pierroz²,

Cooper

et al. 2016

European Journal of Endocrinology

131

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Subjects with type 1 diabetes mellitus (T1DM) have decreased bone mineral density and an up to sixfold increase in fracture risk. Yet bone fragility is not commonly regarded as another unique complication of diabetes. Both animals with experimentally induced insulin deficiency syndromes and patients with T1DM have impaired osteoblastic bone formation, with or without increased bone resorption. Insulin/IGF1 deficiency appears to be a major pathogenetic mechanism involved, along with glucose toxicity, marrow adiposity, inflammation, adipokine and other metabolic alterations that may all play a role on altering bone turnover. In turn, increasing physical activity in children with diabetes as well as good glycaemic control appears to provide some improvement of bone parameters, although robust clinical studies are still lacking. In this context, the role of osteoporosis drugs remains unknown.

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Section: Fracture Riskmentioning

confidence: 90%

“…In 1934 several cases of diabetes associated with vertebral crush fractures were reported from the Joslin clinic (5). Albright & Reifenstein (6) confirmed these findings and Hernberg (7) reported in 1952 that osteoporosis was much more severe in young adults with diabetes at post mortem.…”

Section: Introductionmentioning

confidence: 87%

MECHANISMS IN ENDOCRINOLOGY: Mechanisms and evaluation of bone fragility in type 1 diabetes mellitus

Hough

Pierroz²,

Cooper

et al. 2016

European Journal of Endocrinology

131

View full text Add to dashboard Cite

show abstract

“…That T1D is associated with bone disorders was demonstrated many decades ago. Thus, as early as 1934 several cases of vertebral fracture were reported in patients with diabetes [1]. Autopsy data confirmed the association a few years later by showing greater severity of osteoporosis in patients with T1D compared to controls without diabetes [2].…”

Section: Effects Of Type 1 Diabetes (T1d) On Bonementioning

confidence: 91%

“…Several studies showed abnormal bone fragility in patients with T1D [1,2]. However, only several years after the publication of these studies was clear evidence of an increased fracture risk obtained.…”

Section: Fracture Risk In Type 1 Diabetes (T1d)mentioning

confidence: 99%