Abnormalities of Electroencephalography Microstates in Drug-Naïve, First-Episode Schizophrenia

Sun, Qiaoling; Zhao, Lianbi; Tan, Liwen

doi:10.3389/fpsyt.2022.853602

Cited by 10 publications

(4 citation statements)

References 56 publications

(99 reference statements)

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“…EEG studies in (awake) patients with schizophrenia used a four-microstate topography solution comparable to the solution in the data presented here. Their cross-sectional comparisons with healthy subjects observed the patients with schizophrenia to have decreased duration 41 , 57-61 and lower frequency of occurrence 59 , 62 , 63 in microstate D. Of note, these studies also observed in patients with schizophrenia prolonged duration 59 , 62-64 and higher frequency of occurrence 57-59 , 63 in microstate C. Thus, changes in quantifiers in microstates D and C occurred within repeated suppression EEG intervals with increasing exposure to anaesthesia in patients with subsequent POD (Supp + |POD + ) that resemble neural network features seen in awake patients experiencing schizophrenic episodes.…”

Section: Discussionmentioning

confidence: 99%

EEG microstate quantifiers and state space descriptors during anaesthesia in patients with postoperative delirium: a descriptive analysis

Neuner,

Wolter,

McCarthy

et al. 2023

Brain Communications

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Postoperative delirium (POD) is a serious sequela of surgery and surgery-related anaesthesia. One recommended method to prevent POD is using bi-frontal EEG-recording. The single, processed index of depth of anaesthesia allows the anaesthetist to avoid episodes of suppression EEG and excessively deep anaesthesia. The study data presented here were based on multichannel (19 channels) EEG recordings during anaesthesia. This enabled the analysis of various parameters of global electrical brain activity. These parameters were used to compare microstate topographies under anaesthesia with those in healthy volunteers and to analyse changes in microstate quantifiers and EEG global state space descriptors with increasing exposure to anaesthesia. Seventy-three patients from the Surgery Depth of Anaesthesia and Cognitive outcome (SuDoCO)-study (SRCTN 36437985) received intraoperative multichannel EEG recordings. Altogether, 720 minutes of artefact-free EEG data, including 210 minutes (29.2%) of suppression EEG, were analysed. EEG microstate topographies, microstate quantifiers (duration, frequency of occurrence, global field power) as well as the state space descriptors Sigma (overall EEG power), Phi (generalized frequency), and Omega (number of uncorrelated brain processes) were evaluated as a function of duration of exposure to anaesthesia, suppression EEG and subsequent development of POD. The major analyses involved covariate-adjusted linear mixed effects models. The older (71±7 years), predominantly male (60%) patients received a median exposure of 210 (range: 75-675) minutes of anaesthesia. During seven post-operative days, 21 patients (29%) developed POD. Microstate topographies under anaesthesia resembled topographies from healthy and much younger awake persons. With increasing duration of exposure to anaesthesia, single microstate quantifiers progressed differently in suppression or non-suppression EEG and in patients with or without subsequent POD. The most pronounced changes occurred during enduring suppression EEG in patients with subsequent POD: Duration and frequency of occurrence of microstates C and D progressed in opposite directions and the state space descriptors showed a pattern of declining uncorrelated brain processes (Omega) combined with increasing EEG variance (Sigma). With increasing exposure to general anaesthesia, multiple changes in the dynamics of microstates and global EEG parameters occurred. These changes varied partly between suppression and non-suppression EEG and between patients with or without subsequent POD. Ongoing suppression EEG in patients with subsequent POD was associated with reduced network complexity in combination with increased overall EEG power. Additionally, marked changes in quantifiers of microstate C and in microstate D occurred. These putatively adverse intraoperative trajectories in global electrical brain activity may be seen as preceding and ultimately predicting POD.

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Section: Discussionmentioning

confidence: 99%

EEG microstate quantifiers and state space descriptors during anaesthesia in patients with postoperative delirium: a descriptive analysis

Neuner,

Wolter,

McCarthy

et al. 2023

Brain Communications

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show abstract

“…Recently, many studies have shown that the microstate indicators of patients with neurological and psychiatric diseases will change accordingly and may become potential biomarkers of certain types of diseases ( de Bock et al, 2020 ; Wang et al, 2021 ; Sun et al, 2022 ). Microstate analysis can also be used as one of the indicators of drug treatment effects in patients with certain diseases ( Serrano et al, 2018 ).…”

Section: Discussionmentioning

confidence: 99%

“…Although the physiological basis of microstate C is still highly controversial, in the study of Britz et al (2010) , microstate C was considered to be part of the salience network, which mainly detected and responded to internal or external stimuli received by other brain networks. The salience network, which plays a key role in switching between central executive functions and default modes, can combine interoceptive information with emotional salience to form subjective representations of one’s own body ( Sun et al, 2022 ). As the “mediator” of the brain, the salience network plays an integral role in the processing of sensorimotor information, general cognition, and the coordination between emotion, pain, and body movement.…”

Section: Discussionmentioning

confidence: 99%

EEG microstate changes during hyperbaric oxygen therapy in patients with chronic disorders of consciousness

Wang

et al. 2023

Front. Neurosci.

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Hyperbaric oxygen (HBO) therapy is an effective treatment for patients with disorders of consciousness (DOC). In this study, real-time electroencephalogram (EEG) recordings were obtained from patients with DOC during HBO therapy. EEG microstate indicators including mean microstate duration (MMD), ratio of total time covered (RTT), global explained variance (GEV), transition probability, mean occurrence, and mean global field power (GFP) were compared before and during HBO therapy. The results showed that the duration of microstate C in all patients with DOC increased after 20 min of HBO therapy (p < 0.05). Further statistical analysis found that the duration of microstate C was longer in the higher CRS-R group (≥8, 17 cases) than in the lower group (<8, 24 cases) during HBO treatment. In the higher CRS-R group, the transition probabilities from microstate A to microstate C and from microstate C to microstate A also increased significantly compared with the probability before treatment (p < 0.05). Microstate C is generally considered to be related to a salience network; an increase in the transition probability between microstate A and microstate C indicates increased information exchange between the auditory network and the salience network. The results of this study show that HBO therapy has a specific activating effect on attention and cognitive control in patients and causes increased activity in the primary sensory cortex (temporal lobe and occipital lobe). This study demonstrates that real-time EEG detection and analysis during HBO is a clinically feasible method for assessing brain function in patients with DOC. During HBO therapy, some EEG microstate indicators show significant changes related to the state of consciousness in patients with chronic DOC. This will be complementary to important electrophysiological indicators for assessing consciousness and may also provide an objective foundation for the precise treatment of patients with DOC.

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“…A growing body of research has found altered properties of EEG microstates in patients with schizophrenia (24)(25)(26). Such findings were interpreted as reflecting the brain network malfunction underlying the symptomatology of schizophrenia.…”

Section: Introductionmentioning

confidence: 99%

Altered Microstate Dynamics and Spatial Complexity in Late-Life Schizophrenia

Lin

Wu²,

Chen³

et al. 2022

Front. Psychiatry

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BackgroundResting-state EEG microstate and omega complexity analyses have been widely used to explore deviant brain function in various neuropsychiatric disorders. This study aimed to investigate the features of microstate dynamics and spatial complexity in patients with late-life schizophrenia (LLS).MethodMicrostate and omega complexity analyses were performed on resting-state EEG data from 39 in patients with LLS and compared with 40 elderly normal controls (NCs).ResultThe duration of microstate classes A and D were significantly higher in patients with LLS compared with NCs. The occurrence of microstate classes A, B, and C was significantly lower in patients with LLS compared with NCs. LLS patients have a lower time coverage of microstate class A and a higher time coverage of class D than NCs. Transition probabilities from microstate class A to B and from class A to C were significantly lower in patients with LLS compared with NCs. Transition probabilities between microstate class B and D were significantly higher in patients with LLS compared with NCs. Global omega complexity and anterior omega complexity were significantly higher in patients with LLS compared with NCs.ConclusionThis study revealed an altered pattern of microstate dynamics and omega complexity in patients with LLS. This may reflect the disturbed neural basis underlying LLS and enhance the understanding of the pathophysiology of LLS.

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Abnormalities of Electroencephalography Microstates in Drug-Naïve, First-Episode Schizophrenia

Cited by 10 publications

References 56 publications

EEG microstate quantifiers and state space descriptors during anaesthesia in patients with postoperative delirium: a descriptive analysis

EEG microstate quantifiers and state space descriptors during anaesthesia in patients with postoperative delirium: a descriptive analysis

EEG microstate changes during hyperbaric oxygen therapy in patients with chronic disorders of consciousness

Altered Microstate Dynamics and Spatial Complexity in Late-Life Schizophrenia

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