Abnormalities of lipoprotein and carbohydrate metabolism in degenerative diseases of the nervous system - Motor neuron disease and spinocerebellar degeneration.

Abstract

MURAI, A., MIYAHARA, T., TANAKA, T., KANEKO, T., SAKO, Y. and KAMEYAMA, M. Abnormalities of Lipoprotein and Carbohydrate Metabolism in Degenerative Diseases of the Nervous System -Motor Neuron Disease and Spinocerebellar Degeneration. Tohoku J. exp. Med., 1983, 139 (4), 365-376 The levels of plasma high density lipoprotein (HDL) cholesterol and plasma triglyceride were determined in 44 patients with motor neuron disease (MND) and in 36 patients with spinocerebellar degeneration (SCD). In both groups the HDL cholesterol levels were significantly lower than those in healthy controls, whereas the plasma triglyceride levels were higher than those in the controls. Glucose levels during the oral glucose tolerance test (GTT) were significantly higher in both MND and SCD groups than in healthy controls. Immunoreactive insulin (IRI) levels during GTT were rather higher at 0 and 120 min in both MND and SCD groups than in healthy controls. Glycosylated hemoglobin levels were lower in MND than in the controls. These results indicate that both lipoprotein and carbohydrate metabolisms were impaired in MND and SCD groups. The possibility was presented that denervation might play a part in the pathogenesis of abnormalities of lipoprotein and carbohydrate metabolisms.---motor neuron disease; spinocerebellar degeneration; high density lipoprotein; glucose tolerance test; glycosylated hemoglobin A number of studies have shown a high incidence of impaired glucose metabolism in patients with amyotrophic lateral sclerosis (ALS) (Ionaescu and Luca

Patients with elevated triglyceride and cholesterol serum levels have a prolonged survival in amyotrophic lateral sclerosis

“…However, these results support a recent study by Dupuis et al [4] who showed that ALS patients had higher serum levels of cholesterol (?19%) and LDL (?33%) as well as a larger extent of fatty lesions in the liver than a control group. The results also seem to confirm early reports of abnormalities of lipid and carbohydrate metabolism in ALS patients [11][12][13]. Pradat et al [14] also recently observed an impaired glucose tolerance of ALS patients compared to controls.…”

Dyslipidemia is a protective factor in amyotrophic lateral sclerosis

“…Several early studies have already reported the presence of hypertriglyceridemia and insulin resistance in a few cases of motor neuron disease. [12][13][14] Our present findings provide further evidence of the influence of peripheral lipidic abnormalities on the course of ALS. Of importance, such metabolic perturbations have been traditionally considered as being detrimental to neurodegeneration.…”

Neural network algorithm for the early detection of Parkinson's disease from blood plasma by FTIR micro-spectroscopy

“…This result supports the previous report of cerebral hypometabolism of glucose [28] and dysfunction of the glycolysis pathway in PD [29]. Furthermore, a study suggests the role of carbohydrate metabolisms in the pathogenesis of motor neuron disease and spinocerebellar degeneration [30]. Also, variation in serum glucose was previously reported in early PD [31] and the validation of plasma glucose level in these samples was shown to be abnormal (unpublished result).…”