Abnormalities of lithium transport across the erythrocyte membrane in depression and schizophrenia

Rybakowski, Janusz; Lehmann, W

doi:10.1016/0006-3223(91)90219-c

Cited by 9 publications

(1 citation statement)

References 28 publications

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“…(4) Alterations in membrane phospholipids could result in changes in ion transport. Abnormalities in lithium transport across erythrocyte membranes have been described in schizophrenia (Rybakowski and Lehmann 1991). These findings are similar to those in affective disorders and may be related to a genetic diathesis (Hibbein et al 1989).…”

Section: Human In Vivo 31p Nmr Studiesmentioning

confidence: 99%

31P Nuclear Magnetic Resonance Spectroscopy: Neurodevelopment and Schizophrenia

Pettegrew

Keshavan

Minshew

1993

Schizophrenia Bulletin

110

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A number of studies have demonstrated alterations in the structure and function of the frontolimbic system in some schizophrenic patients. Recent in vivo phosphorus-31 nuclear magnetic resonance studies of the dorsal prefrontal cortex in neuroleptic-naive, first-episode schizophrenic patients and matched controls have shown evidence of alterations in membrane phospholipid and energy metabolism. The membrane alterations observed in the schizophrenic patients are compatible with either premature aging or altered timing and exaggeration of regressive events occurring during normal brain development. These molecular changes may precede onset of clinical symptoms and brain structural changes in schizophrenia and suggest fresh approaches to the pathogenesis and treatment of this illness.

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Section: Human In Vivo 31p Nmr Studiesmentioning

confidence: 99%