Abnormalities of localized connectivity in schizophrenia patients and their unaffected relatives: a meta-analysis of  resting-state functional magnetic resonance imaging studies

Xiao, Bo; Wang, Shuai; Li, Jianbo; Meng, Tiantian; He, Yiqing; Luo, Xuerong

doi:10.2147/ndt.s126678

Cited by 43 publications

(36 citation statements)

References 53 publications

(56 reference statements)

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“…Our study found increased ReHo values in right SFG. A meta-analysis also showed increased ReHo values in the SFG in both patients with first-episode schizophrenia and with treated schizophrenia [13]. The SFG is a significant component of the DLPFC [61].…”

Section: Discussionmentioning

confidence: 91%

Relationships between abnormal neural activities and cognitive impairments in patients with drug-naive first-episode schizophrenia

Yan

Zhang

Zhou

et al. 2020

Preprint

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Background Prior resting state functional magnetic resonance imaging studies via the regional homogeneity (ReHo) method have demonstrated inconsistent and conflicting results because of several confounding factors, such as small sample size, medicinal influence, and illness duration. Relationships between ReHo measures and cognitive impairments in patients with drug-naive first-episode schizophrenia (dn-FES) are rarely reported. This study was conducted to explore the correlations between ReHo measures, cognitive deficits, and clinical symptoms in patients with dn-FES. Methods A total of 69 patients with dn-FES and 74 healthy controls were recruited. MATRICS Consensus Cognitive Battery (MCCB), Wechsler Adult Intelligence Scale (WAIS), and Positive and Negative Syndrome Scale (PANSS) were used to assess cognitive function, intelligence quotient (IQ), and clinical symptoms, respectively. The correlations between ReHo map and cognitive deficits, the severity of symptoms were examined using strict correlation analyses within brain areas. Results The ReHo values in the right middle frontal gyrus (MFG) and the superior frontal gyrus (SFG) increased in the dn-FES group, whereas the ReHo values in the right cuneus decreased. Correlation analysis showed that the ReHo values in the right MFG were positively correlated with attention/vigilance impairments, social cognition deficits, the severity of clinical manifestations. Conclusions These findings suggested that abnormal spontaneous activities in the right MFG reflect the illness severity and cognitive deficits, which serves as a basis for establishing the objective diagnostic markers and might be a clinical intervention target for patients with schizophrenia.

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Section: Discussionmentioning

confidence: 91%

Relationships between abnormal neural activities and cognitive impairments in patients with drug-naive first-episode schizophrenia

Yan

Zhang

Zhou

et al. 2020

Preprint

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“…This data set is available at a previous study [7] and contains raw anatomical and functional MR data from patients with Schizophrenia and healthy controls, ranging in age from 18 to 65 years old. Resting fMRI, anatomical MRI, phenotype data for every participant including gender, age, handedness and diagnostic information are released.…”

Section: Data Source and Availabilitymentioning

confidence: 99%

“…Also, schizophrenia is associated with volume deficits in PreCG [5] . Another research indicates the patients with schizophrenia showed lower activation in left PreCG than right PreCG [6] and a regional homogeneity (ReHo) study showed decreased ReHo in right precentral gyrus [7] . In this research, we examined the PreCG functional connectivity impairment in patients with schizophrenia using ROI based analysis [8] .…”

Section: Introductionmentioning

confidence: 99%

Precentral gyrus abnormal connectivity in male and female patients with schizophrenia

Zarei¹

2018

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Aim: Dysfunction of the precentral gyrus plays a role in the impairments of voluntary movement associated with schizophrenia and it has significantly reduced functional activity in patients with schizophrenia. The aim of this study was to demonstrate the precentral gyrus alteration and its abnormal connectivity in schizophrenia. Methods:The region of interest-based analysis method was used to investigate the precentral gyrus connectivity alteration in schizophrenia. The resting-state functional magnetic resonance imaging data of healthy control subjects and patients with schizophrenia (Centers of Biomedical Research Excellence data set) was used to examine the aberrant functional brain connectome in schizophrenia. This data set contains raw anatomical and functional magnetic resonance data from 72 patients with schizophrenia and 75 healthy controls, ranging in age from 18 to 65 years old. Results:Our results show precentral gyrus has abnormal communication with thalamus, hippocampus, parahippocampal gyrus, posterior division of supramarginal gyrus and medial prefrontal cortex (pFDR = 0.05). This information is expected to provide a better understanding of altered functional connectivity of the precentral gyrus in the male and female patients with schizophrenia. Conclusion:Collectively, these findings support the hypothesis that precentral gyrus has an abnormal connectivity in schizophrenia and this alteration is not the same in the male and female patients with schizophrenia.

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“…Also, SCH is associated with volume deficits in Precentral gyrus [15]. Another research indicates that the patients with SCH showed lower activation in left PreCG than right PreCG [10] and a regional homogeneity (ReHo) study showed decreased ReHo in right Precentral gyrus [19].…”

Section: Introductionmentioning

confidence: 98%

Precentral gyrus abnormal connectivity in male and female schizophrenia patients

Zarei

2017

Preprint

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The present study demonstrates the Precentral gyrus (PreCG) alteration and its abnormal connectivities in Schizophrenia (SCH) patients. The resting-sate functional magnetic resonance imaging (rs-fMRI) data of healthy control subjects and SCH patients (Centre for Biomedical Research Excellence data set) are used to examine the aberrant functional brain connectome in SCH which contains raw anatomical and functional MR data from 72 patients with Schizophrenia and 75 healthy controls, ranging in age from 18 to 65 years old. Our results show that PreCG has abnormal communication with Thalamus, Hippocampus, Parahippocampal Gyrus (pPaHC), posterior division of Supramarginal Gyrus (pSMG) and medial prefrontal cortex (mPFC) (p-FDR=0.05).

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Abnormalities of localized connectivity in schizophrenia patients and their unaffected relatives: a meta-analysis of resting-state functional magnetic resonance imaging studies

Cited by 43 publications

References 53 publications

Relationships between abnormal neural activities and cognitive impairments in patients with drug-naive first-episode schizophrenia

Relationships between abnormal neural activities and cognitive impairments in patients with drug-naive first-episode schizophrenia

Precentral gyrus abnormal connectivity in male and female patients with schizophrenia

Precentral gyrus abnormal connectivity in male and female schizophrenia patients

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