Abnormalities of regional brain function in Parkinson’s disease: a meta-analysis of resting state functional magnetic resonance imaging studies

Pan, PingLei; Zhang, Yang; Liu, Yi; Zhang, He; Guan, Di; Xu, Yun

doi:10.1038/srep40469

Cited by 50 publications

(47 citation statements)

References 89 publications

(150 reference statements)

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“…Reduced ALFF was also found in the occipital cortex (i.e., middle occipital gyrus) and parietal cortex (i.e., precuneus) in the PD_MCI group. This nding was also consistent with the previous studies that identify spontaneous neural activity in PD patients by resting-state MRI [32,33]. More emerging evidence also indicates the occipital and parietal cortex are crucial involvement in the pathophysiology of PD.…”

Section: Discussionsupporting

confidence: 92%

The Functional and Structural Changes of the Brain in Parkinson's Disease Patients with Mild Cognitive Impairment

Ji¹,

Zhao²,

Cui³

et al. 2020

Preprint

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Background: Parkinson's disease (PD) is often associated with cognitive impairment. However, the neural mechanism of cognitive impairment is not clear. The present study investigated the functional and anatomic changes in PD patients with mild cognitive impairment (MCI) and their correlations with cognitive functions by the application of combined functional and structural analysis. Methods: T1-weighted magnetic resonance imaging (MRI) and resting-state functional MRI data were acquired from 23 PD patients with MCI (PD-MCI), 23 PD patients with normal cognitive function (PD-NCI), and 23 matched healthy controls (HC). The structural imaging data was analyzed by voxel-based morphometry (VBM) and surfaced-based morphometry (SBM) methods to assess the changes of gray matter density and cortical thickness, respectively. And the amplitude of low-frequency fluctuations (ALFF) analysis using resting-state functional imaging data to measure the spontaneous changes of brain activity. Their Correlations with neuropsychological assessments (e.g., Montreal cognitive assessment, MOCA; Mini-mental state examination, MMSE) were also examined. Results: Compared to the HC group, the PD-MCI patient group showed both decreased ALFF in the occipital regions (i.e., left middle occipital gyrus) and parietal regions (i.e., left precuneus) and increased ALFF in the right inferior frontal gyrus and bilateral hippocampus. Also, the PD-MCI patient group showed reduced gray matter density in the right inferior frontal gyrus and middle frontal gyrus. Cortical thinning in the left middle temporal gyrus and right superior temporal gyrus was found in the PD_MCI patient group relative to the control group. Furthermore, ALFF of the right hippocampus and gray matter density of right frontal gyrus was correlated with cognitive impairment (e.g., MOCA ), respectively. Cortical thickness of right superior temporal gyrus was also associated with cognitive deficit (e.g., MMSE ). Conclusion: MCI in PD is associated with widespread brain functional and structural alternations. The combination of functional and structural abnormalities may be related to subtle cognitive impairment in PD.

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Section: Discussionsupporting

confidence: 92%

The Functional and Structural Changes of the Brain in Parkinson's Disease Patients with Mild Cognitive Impairment

Ji¹,

Zhao²,

Cui³

et al. 2020

Preprint

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“…4a). The left hemisphere of PD patients was particularly vulnerable to aging changes in DNA methylation, concordant with previous PD imaging studies [5,[52][53][54][55]. Interestingly, in both PD patients and controls, DNA methylation at enhancers and promoters became increasingly symmetrical across hemispheres with aging ( Fig.…”

Section: Changes In Hemispheric Asymmetry In Neurons With Agingsupporting

confidence: 90%

Hemispheric asymmetry in the human brain and in Parkinson’s disease is linked to divergent epigenetic patterns in neurons

Ensink

Lang

et al. 2020

Genome Biol

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Background: Hemispheric asymmetry in neuronal processes is a fundamental feature of the human brain and drives symptom lateralization in Parkinson's disease (PD), but its molecular determinants are unknown. Here, we identify divergent epigenetic patterns involved in hemispheric asymmetry by profiling DNA methylation in isolated prefrontal cortex neurons from control and PD brain hemispheres. DNA methylation is fine-mapped at enhancers and promoters, genome-wide, by targeted bisulfite sequencing in two independent sample cohorts. Results: We find that neurons of the human prefrontal cortex exhibit hemispheric differences in DNA methylation. Hemispheric asymmetry in neuronal DNA methylation patterns is largely mediated by differential CpH methylation, and chromatin conformation analysis finds that it targets thousands of genes. With aging, there is a loss of hemispheric asymmetry in neuronal epigenomes, such that hemispheres epigenetically converge in late life. In neurons of PD patients, hemispheric asymmetry in DNA methylation is greater than in controls and involves many PD risk genes. Epigenetic, transcriptomic, and proteomic differences between PD hemispheres correspond to the lateralization of PD symptoms, with abnormalities being most prevalent in the hemisphere matched to side of symptom predominance. Hemispheric asymmetry and symptom lateralization in PD is linked to genes affecting neurodevelopment, immune activation, and synaptic transmission. PD patients with a long disease course have greater hemispheric asymmetry in neuronal epigenomes than those with a short disease course. Conclusions: Hemispheric differences in DNA methylation patterns are prevalent in neurons and may affect the progression and symptoms of PD.

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“…4a). The left hemisphere of PD patients was particularly vulnerable to aging changes in DNA methylation, concordant with previous PD imaging studies 5,[51][52][53][54] . Interestingly, in both PD patients and controls, DNA methylation at enhancers and promoters became increasingly symmetrical across hemispheres with aging ( Fig.…”

Section: Changes In Hemispheric Asymmetry In Healthy and Pd Neurons Wsupporting

confidence: 90%

Epigenetic contributions to hemisphere asymmetry in healthy brain, aging, and Parkinson’s disease

Li¹,

Ensink²,

Lang³

et al. 2019

Preprint

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Hemispheric asymmetry in neuronal processes is a fundamental feature of the human brain and drives symptom lateralization in Parkinson's disease (PD), but its molecular determinants are unknown. Here, we determine epigenetic differences involved in hemispheric asymmetry in the healthy and the PD brain. Neurons of the healthy brain exhibit numerous hemispheric differences in DNA methylation, which affect genes implicated in neurodegenerative diseases.In PD patients, hemispheric asymmetry in DNA methylation is even greater and involves many PD risk genes. The lateralization of clinical PD symptoms involves epigenetic, transcriptional, and proteomic differences across hemispheres that affect neurodevelopment, immune activation, and synaptic transmission. During aging, healthy neurons show a progressive loss of hemispheric asymmetry in the epigenome, which is amplified in PD. For PD patients, a long disease course is associated with greater hemispheric asymmetry in neuronal epigenomes than a short disease course. Hemispheric differences in epigenetic gene regulation are prevalent in neurons and may affect the progression and symptoms of PD.

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Abnormalities of regional brain function in Parkinson’s disease: a meta-analysis of resting state functional magnetic resonance imaging studies

Cited by 50 publications

References 89 publications

The Functional and Structural Changes of the Brain in Parkinson's Disease Patients with Mild Cognitive Impairment

The Functional and Structural Changes of the Brain in Parkinson's Disease Patients with Mild Cognitive Impairment

Hemispheric asymmetry in the human brain and in Parkinson’s disease is linked to divergent epigenetic patterns in neurons

Epigenetic contributions to hemisphere asymmetry in healthy brain, aging, and Parkinson’s disease

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