Abnormalities of the small intestinal mucosa in Crohn's Disease (regional enteritis)

Shiner, Margot; Drury, R. A. B.

doi:10.1007/bf02236112

Cited by 39 publications

(11 citation statements)

References 15 publications

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“…The involved area is thus usually inaccessible either to routine peroral small bowel biopsy or to biopsy through the sigmoidoscope. Non-specific atrophic mucosal changes have been reported in the proximal small bowel in patients with regional enteritis (Shiner and Drury, 1962) but a diagnosis of granulomatous disease is difficult to make by this technique since the characteristic changes are submucosal. When the rectum is involved in the disease process, granulomas may be found on deep biopsy through the sigmoidoscope, but in our experience the rectum is commonly free of disease.…”

Section: Pathological Featuresmentioning

confidence: 99%

Granulomatous ileocolitis

Marshak¹,

Lindner²,

Janowitz³

1966

Gut

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Section: Pathological Featuresmentioning

confidence: 99%

Granulomatous ileocolitis

Marshak¹,

Lindner²,

Janowitz³

1966

Gut

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“…Several studies have shown that small intesti nal mucosal abnormalities and decreased disaccharidase activity occur in patients with ulcer ative colitis (2,6,12) and Crohn's disease (4,13). Decreased levels of lactase activity may occur in ulcerative colitis as has been shown by Cady et al (2) and Gudmand-Hoyer et al (6).…”

Section: Discussionmentioning

confidence: 72%

Abnormalities of Jejunal Mucosal Enzymes in Ulcerative Colitis and Crohn’s Disease

Arvanitakis¹

1979

Digestion

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Jejunal mucosal function and structure was examined in 31 patients with ulcerative colitis and 29 patients with Crohn’s disease with ileal, ileocolonic or colonic involvement. A significant reduction of the specific activity of disaccharidases (lactase, sucrase and trehalase) in jejunal mucosal homogenate occurred in patients with inflammatory bowel disease. Similarly, alkaline phosphatase was reduced in ulcerative colitis. Several dipeptidases such as glycyl-leucine, leucyl-glycine, glycyl-glycine and valyl-proline hydrolase activities were lower in patients with inflammatory bowel disease than in controls. Histological changes in jejunal mucosal biopsies occurred in 71% of patients with ulcerative colitis and 61% with Crohn’s disease. These changes ranged from mild abnormalities of villus architecture to marked reduction of villus height. Most patients with a reduction in mucosal enzymes had concommitant morphological changes in jejunal mucosal biopsy. The results of this study indicate that functional and structural abnormalities of the jejunal mucosa frequently occur in patients with inflammatory bowel disease without radiologic evidence of proximal small bowel involvement.

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“…Aside from the enzyme abnormalities found in affected areas of the intestine, a number of recent findings have led to the concept that there may be brush border alter ations also in areas of normal macroscopic and microscopic appearance [10,17,18]. The finding that lysophospholipase activity was decreased also in apparently healthy resec tion margins (table II) could, therefore, add some further weight to the growing concept that CD is a continuous disorder of the entire gastrointestinal tract.…”

Section: Discussionmentioning

confidence: 95%

Decreased Lysophospholipase and Increased Phospholipase A<sub>2 </sub>Activity in Heal Mucosa from Patients with Crohn’s Disease

Bolin¹,

Heuman²,

Sjödahl³

et al. 1984

Digestion

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Lysophospholipase (EC 3.1.1.5) and phospholipase A₂ (EC 3.1.1.4) were determined in ileal mucosa from patients with Crohn’s disease (CD) and non-inflammatory bowel diseases (NIBD). In addition, the activities of alkaline phosphatase, sucrase, maltase, and lactase were determined. The lysophospholipase activity, like that of alkaline phosphatase, sucrase and maltase, was decreased in affected areas of CD, whereas the phospholipase A₂activity was rather increased. Lysophospholipase and phospholipase A₂ activities in apparently unaffected mucosa from CD patients were in between those in healthy mucosa from NIBD patients and those in affected mucosa from CD patients. These findings point to the possibility that the mucosal activity of lysophospholipase, like that of other brush border enzymes, is decreased in CD. This may render the mucosa less capable to handle lysolecithin, a potentially harmful agent formed in the intestine and known to induce inflammation in a number of experimental systems.

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Abnormalities of the small intestinal mucosa in Crohn's Disease (regional enteritis)

Cited by 39 publications

References 15 publications

Granulomatous ileocolitis

Granulomatous ileocolitis

Abnormalities of Jejunal Mucosal Enzymes in Ulcerative Colitis and Crohn’s Disease

Decreased Lysophospholipase and Increased Phospholipase A<sub>2 </sub>Activity in Heal Mucosa from Patients with Crohn’s Disease

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