Abnormalities of the uncinate fasciculus and posterior cingulate fasciculus in mild cognitive impairment and early Alzheimer's disease: A diffusion tensor tractography study

Kiuchi, Kuniaki; Morikawa, Masayuki; Taoka, Toshiaki; Nagashima, Tomohisa; Yamauchi, Takahira; Makinodan, Manabu; Norimoto, Kazunobu; Hashimoto, Kazumichi; Kosaka, Jun; Inoue, Yuichiro; Inoue, Makoto; Kichikawa, Kimihiko; Kishimoto, Toshifumi

doi:10.1016/j.brainres.2009.06.052

Cited by 106 publications

(99 citation statements)

References 41 publications

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“…Although the FA has been widely used as a measure to assess the integrity of brain connections (Kiuchi et al, 2009;Pievani et al, 2010;Teipel et al, 2010), we did not observe any trends toward significance in this parameter in our study.…”

Section: Discussioncontrasting

confidence: 88%

“…Diffusion MRI (dMRI) is a technique that can be used to analyze differences in structural integrity and brain connectivity, and has been successfully employed to detect differences between Alzheimer's patients and healthy control subjects (Kiuchi et al, 2009;Pievani et al, 2010;Teipel et al, 2010). dMRI measures water diffusion within a tissue, with common dMRI measures including fractional anisotropy (FA), a measure of the degree of diffusion anisotropy where a value of zero means that diffusion is unrestricted (or equally restricted) and a value of one means that diffusion only occurs along one axis and is fully restricted in all other directions, mean diffusivity, a measure describing the extent of free diffusion without assuming a particular direction, axial diffusivity (AD; also known as parallel diffusivity), a measure of the extent of water moving along the primary axis of diffusion, and radial diffusivity (RD; also known as perpendicular diffusivity), a measure of water movement along the minor axes perpendicular to the primary axis.…”

Section: Introductionmentioning

confidence: 99%

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Diffusion-weighted magnetic resonance imaging detection of basal forebrain cholinergic degeneration in a mouse model

et al. 2013

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AbbreviationsChAT: Choline acetyl transferase dMRI: diffusion MRI FA: fractional anisotropy MCI: mild cognitive impairment MRI: magnetic resonance imaging p75 NTR : p75 neurotrophin receptor PB: phosphate buffer PBS: phosphate buffered saline ROI: region of interest SAP: saporin KeywordsCholinergic basal forebrain, tractography, p75 neurotrophin receptor, MRI, diffusion weighted imaging, neurodegeneration 3

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Section: Discussioncontrasting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Diffusion-weighted magnetic resonance imaging detection of basal forebrain cholinergic degeneration in a mouse model

et al. 2013

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“…The orientations of WM pathways can also be inferred by the principal eigenvector of the diffusion tensor (Basser et al, 1994), which provides a new opportunity to investigate WM pathways in living humans (for review, see Mori and van Zijl, 2002). In AD patients, neural degenerations have been identified in a variety of WM tracts, including the corpus callosum (Rose et al, 2000;Naggara et al, 2006;Ukmar et al, 2008) and posterior cingulate fasciculus (Kiuchi et al, 2009). Despite these advances for alterations of specific tracts, however, little is known about the abnormalities of topological organization in WM network in AD.…”

Section: Introductionmentioning

confidence: 99%

Diffusion Tensor Tractography Reveals Abnormal Topological Organization in Structural Cortical Networks in Alzheimer's Disease

Lo¹,

Wang²,

Chou³

et al. 2010

J. Neurosci.

520

428

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Recent research on Alzheimer's disease (AD) has shown that the decline of cognitive and memory functions is accompanied by a disrupted neuronal connectivity characterized by white matter (WM) degeneration. However, changes in the topological organization of WM structural network in AD remain largely unknown. Here, we used diffusion tensor image tractography to construct the human brain WM networks of 25 AD patients and 30 age-and sex-matched healthy controls, followed by a graph theoretical analysis. We found that both AD patients and controls had a small-world topology in WM network, suggesting an optimal balance between structurally segregated and integrative organization. More important, the AD patients exhibited increased shortest path length and decreased global efficiency in WM network compared with controls, implying abnormal topological organization. Furthermore, we showed that the WM network contained highly connected hub regions that were predominately located in the precuneus, cingulate cortex, and dorsolateral prefrontal cortex, which was consistent with the previous diffusion-MRI studies. Specifically, AD patients were found to have reduced nodal efficiency predominantly located in the frontal regions. Finally, we showed that the alterations of various network properties were significantly correlated with the behavior performances. Together, the present study demonstrated for the first time that the Alzheimer's brain was associated with disrupted topological organization in the large-scale WM structural networks, thus providing the structural evidence for abnormalities of systematic integrity in this disease. This work could also have implications for understanding how the abnormalities of structural connectivity in AD underlie behavioral deficits in the patients.

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“…[11][12][13][14][15][16][17][18][19] We compared FA values of the extracted anterior and posterior CBs made by each of the 3 extraction methods across 15 NC, 15 patients with PD, and 15 patients with PDD. One operator (K.I.)…”

Section: Comparison Of Fa Values Between Groupsmentioning

confidence: 99%

“…[6][7][8][9] Tract-speciˆc analysis (TSA) is based on diŠusion parameters along the speciˆcˆbers that have been identiˆed by DTT. 10 In the literature, TSA of the CB has been reported eŠective in Alzheimer disease (AD), [11][12][13][14][15] schizophrenia, [16][17][18] and Parkinson's disease without (PD) and with dementia (PDD). 19 It is therefore important to quantify water molecule diŠusion of the CB accurately for the diagnosis of these pathological conditions.…”

Section: Introductionmentioning

confidence: 99%

Automatic Extraction of the Cingulum Bundle in Diffusion Tensor Tract-specific Analysis: Feasibility Study in Parkinson's Disease with and without Dementia

et al. 2013

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Purpose: Tract-speciˆc analysis (TSA) measures diŠusion parameters along a speciˆĉ ber that has been extracted byˆber tracking using manual regions of interest (ROIs), but TSA is limited by its requirement for manual operation, poor reproducibility, and high time consumption. We aimed to develop a fully automated extraction method for the cingulum bundle (CB) and to apply the method to TSA in neurobehavioral disorders such as Parkinson's disease (PD).Materials and Methods: We introduce the voxel classiˆcation (VC) and auto diŠusion tensorˆber-tracking (AFT) methods of extraction. The VC method directly extracts the CB, skipping theˆber-tracking step, whereas the AFT method usesˆber tracking from automatically selected ROIs. We compared the results of VC and AFT to those obtained by manual diŠusion tensorˆber tracking (MFT) performed by 3 operators. We quantiˆed the Jaccard similarity index among the 3 methods in data from 20 subjects (10 normal controls [NC] and 10 patients with Parkinson's disease dementia [PDD]). We used all 3 extraction methods (VC, AFT, and MFT) to calculate the fractional anisotropy (FA) values of the anterior and posterior CB for 15 NC subjects, 15 with PD, and 15 with PDD.Results: The Jaccard index between results of AFT and MFT, 0.72, was similar to the inter-operator Jaccard index of MFT. However, the Jaccard indices between VC and MFT and between VC and AFT were lower. Consequently, the VC method classiˆed among 3 diŠerent groups (NC, PD, and PDD), whereas the others classiˆed only 2 diŠerent groups (NC, PD or PDD).Conclusion: For TSA in Parkinson's disease, the VC method can be more useful than the AFT and MFT methods for extracting the CB. In addition, the results of patient data analysis suggest that a reduction of FA in the posterior CB may represent a useful biological index for monitoring PD and PDD.

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Abnormalities of the uncinate fasciculus and posterior cingulate fasciculus in mild cognitive impairment and early Alzheimer's disease: A diffusion tensor tractography study

Cited by 106 publications

References 41 publications

Diffusion-weighted magnetic resonance imaging detection of basal forebrain cholinergic degeneration in a mouse model

Diffusion-weighted magnetic resonance imaging detection of basal forebrain cholinergic degeneration in a mouse model

Diffusion Tensor Tractography Reveals Abnormal Topological Organization in Structural Cortical Networks in Alzheimer's Disease

Automatic Extraction of the Cingulum Bundle in Diffusion Tensor Tract-specific Analysis: Feasibility Study in Parkinson's Disease with and without Dementia

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