Abnormalities of thyroid function in infants with Down syndrome

Down Syndrome and Thyroid Disorders: A Review

“…Tunbridge et al, (1977) found the prevalence of hypothyroidism in the general population (aged 18 years and older), to be 0.8%-1.1%, and the prevalence of hyperthyroidism as 1.1%-1.6%. A large study of congenital hypothyroidism in neonates with Down syndrome reported a prevalence of 0.12%; twenty-eight times greater than for the general population (Fort et al, 1984). The prevalence of acquired thyroid disorders increases with age, with higher rates being found for older persons with Down syndrome (Baxter et al, 1975;Korsager et al, 1978;Vladutiu et al, 1984;Dinani & Carpenter, 1990).…”

“…Verma & Ghal, 1971;King et al, 1978) or be acquired (occur at any age after birth). The neonatal screening programme by Fort et al (1984) found an incidence of congenital hypothyroidism of 1:141 live births (12 infants who had hypothyroidism out of 1130 live births). Three of the 12 infants with Down syndrome had transient hypothyroidism which resolved without intervention.…”

Functional Status of Thyroid Gland in Hospitalized Children With Down’s Syndrome

“…8 Fort et al reported 12 cases of congenital hypothyroidism out of 1130 infants of DS with an incidence of 1:141 compared to 1:3800 in the general population. 9 The forms of hypothyroidism found in individuals with DS include congenital hypothyroidism, subclinical or 'compensated' hypothyroidism, uncompensated, transient and primary hypothyroidism, central hypothyroidism, thyroxin-binding globulin deficiency and chronic lymphocytic thyroiditis. 10 The diagnosis of hypothyroidism in DS is complicated by the overlap between thyroid-associated symptoms and clinical features of the syndrome.…”

Down Syndrome with Thyroid Dysfunction Detected by Neonatal Screening for Congenital Hypothyroidism

“…However, it has recently been recognized that DS with various degrees of neonatal thyroid dysfunction can be detected by neonatal screening for CH (7,8 …”