Abnormality on Liver Function Test

Abstract

Children with abnormal liver function can often be seen in outpatient clinics or inpatients wards. Most of them have respiratory disease, or gastroenteritis by virus infection, accompanying fever. Occasionally, hepatitis by the viruses causing systemic infection may occur, and screening tests are required. In patients with jaundice, the tests for differential diagnosis and appropriate treatment are important. In the case of a child with hepatitis B virus infection vertically from a hepatitis B surface antigen positive mother, the importance of the recognition of immune clearance can't be overstressed, for the decision of time to begin treatment. Early diagnosis changes the fate of a child with Wilson disease. So, screening test for the disease should not be omitted. Non-alcoholic fatty liver disease, which is mainly discovered in obese children, is a new strong candidate triggering abnormal liver function. Muscular dystrophy is a representative disease mimicking liver dysfunction. Although muscular dystrophy is a progressive disorder, and early diagnosis can't change the fate of patients, it will be better to avoid parent's blame for delayed diagnosis.

Inulin-type fructans trigger changes in iron concentration and activity of bone metabolism biomarkers in blood plasma of growing pigs

“…Both total protein and albumin concentrations in blood plasma are considered as markers of the liver functioning, reflecting partly its nutritional status (Kang, 2013). In the present study, unaffected total plasma protein and increased plasma albumin level in pigs fed both experimental diets may indicate physiological liver and gallbladder functions.…”

“…The above may be confirmed by the fact that we showed significantly lower plasma activity of GGT in pigs fed diet with chicory root addition. Kang (2013) suggested that increased ALP activity with the significant increase in GGT activity must originate from the liver rather than metabolic activity of bones. Additionally, in human adolescents predominant ALP serum activity derives from bone origin ALP fraction as the effect of intense skeletal growth (Van Hoof et al, 1990;Kang, 2013).…”

“…Kang (2013) suggested that increased ALP activity with the significant increase in GGT activity must originate from the liver rather than metabolic activity of bones. Additionally, in human adolescents predominant ALP serum activity derives from bone origin ALP fraction as the effect of intense skeletal growth (Van Hoof et al, 1990;Kang, 2013). Serum total ALP activity is proposed as a marker of bone formation and osteoblast activity in growing adolescent pigs (Tymczyna et al, 2012).…”

The effect of locally manufacture pots on levels of alp &ldh enzymes

“…The results obtained from this study were supported the assumption that heavy elements released in feeds cooked in cooking pots made of Atmonia and Pepsi cans were the main reasons of high elevation of liver functioning enzymes of Wistar rats such as AST, ALT and ALP. Alkaline ) an enzyme also found in the liver, bile Soo Kang, 2013). High levels of these enzymes may cause liver damage or disease, a blocked bile Paul and Giboney, (2005) reported that some toxic heavy elements were able to cause significant increase in LDH amounts in liver.…”

Levels of ast and alt in wistar rats treated with heavy metals released from atamonia and pepsi cans (=tins=) as cooking pots during feeding

“…The results obtained from this study were supported the assumption that heavy elements released in feeds cooked in cooking pots made of Atmonia and Pepsi cans were the main reasons of high elevation of liver functioning enzymes of Wistar rats such as AST, ALT and ALP. Alkaline phosphatase (ALP) an enzyme also found in the liver, bile ducts, and bones (Ki-Soo Kang, 2013). High levels of these enzymes may cause liver damage or disease, a blocked bile duct, or bone disease.…”