ABO and Rh Blood Groups and Risk of Colorectal Adenocarcinoma

Abstract

Background: Previous studies have observed an association between ABO blood group and risk for certain gastrointestinal malignancies, including pancreatic and gastric cancer. However, it is unclear whether there is such an association with colorectal cancer (CRC). In this study, possible relationships between ABO blood groups and Rh factor and KRAS status in patients with CRC were investigated. Materials and Methods: In 1,620 patients with CRC, blood group and Rh factor were examined and compared with the control group of 3,022,883 healthy volunteer blood donors of the Turkish Red Crescent between 2004 and 2011. The relationship of blood groups with wild type K-ras status was also evaluated. Results: Overall distributions of ABO blood groups as well as Rh factor were comparable between patients (45% A, 7.2% AB, 16.4% B, 31.4% O, and 87.2% Rh+) and controls (42.2% A, 7.6% AB, 16.3% B, 33.9% O, and 87.7% Rh+) (p=0.099). However, there were statistically significant difference between patients and controls with respect to O vs. non O blood group (p=0.033) and marginally significant difference for A vs. non-A blood group (p=0.052). Among patients, the median age was 62 (range 17-97), 58.1% were male. There were no statistically significant differences respect to sex and K-ras status. Conclusion: In present study, the ABO/Rh blood groups were statistically significantly associated with the risk of CRC. There were no relationship between K-ras status and ABO blood group and Rh factor. However further studies with larger numbers of patients are needed to establish the role of blood groups and to define the mechanisms by which ABO blood type affect CRC.

Risk Factors Associated with Colorectal Cancer in a Subset of Patients with Mutations in MLH1 and MSH2 in Taiwan Fulfilling the Amsterdam II Criteria for Lynch Syndrome

“…The association between blood group type and CRC risk has rarely been investigated. To date, only one case-control study has reported an association between blood group type O and CRC risk [ 27 ]. However, our study revealed that only MSH2 germline mutation carriers with blood group B exhibited an increased CRC risk (HR = 2.64, 95% CI = 1.06–6.58).…”

Association of ABO Blood Group and Risk of Lung Cancer in a Multicenter Study in Turkey

“…Furthermore, recent studies have reported an association between ABO blood group and the risk of various epithelial cancers. Non-O blood group increases risk of cancer including pancreatic, gastric, ovarian, kidney, colorectal and skin carcinomas (Wolpin et al, 2009;Edgren et al, 2010;Xie et al, 2010;Joh et al, 2012;Poole et al, 2012;Urun et al, 2012). Similarly, the thrombosis was associated with both increased risk of cancer and advanced disease and poor prognosis (Chew et al, 2006;Ahlbrecht et al, 2012).…”

“…ABO blood group gene is mapped at the chromosome 9q34, in which the genetic alterations are common (Humphray et al, 2004). The correlation of ABO blood groups with certain disease including infections, vascular, and malignant diseases has been shown (Hakomori, 2001 (Wolpin et al, 2009;Edgren et al, 2010;Joh et al, 2012;Poole et al, 2012;Urun et al, 2012). However, the data on the role of ABO blood group and Rh factor in lung cancer is limited and inconsistent (Alvarez-Fernandez and Carretero-Albinana, 1991;Lee et al, 1991;Cerny et al, 1992;Miyake et al, 1992;Gwin et al, 1994;Rice et al, 1995;Graziano et al, 1997;Ulger et al, 2002;SanchezMora et al, 2007;Suadicani et al, 2007;Leon-Atance et al, 2012).…”

The Relationship between ABO Blood Group and Glioblastoma Multiforme

“…In similarly, in other study it was found that the A blood group was associated with a modestly increased ovarian cancer risk compared to blood group O [6]. Also it was found that there were statistically significant difference between patients and controls with respect to O vs. non O blood group [7]. Glioblastoma (GBM) is the most common type of primary brain tumor.…”