ABO blood group and ovarian reserve: a meta-analysis and systematic review

Deng, Jiehui; Jia, Mengmeng; Cheng, Xiaolin; Zhen, Yan; Fan, Daiming; Tian, Xiaoyu

doi:10.18632/oncotarget.15759

Cited by 9 publications

(7 citation statements)

References 34 publications

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“…A study by Nejat et al in 2011 reported that blood types A and AB are more associated with low ovarian reserve [57]. However, such results were not repeated in other subsequent studies, including a metaanalysis on the subject [58][59][60].…”

Section: Abo Blood Typementioning

confidence: 99%

Risk factors for inadequate response to ovarian stimulation in assisted reproduction cycles: systematic review

Amaral

Ejzenberg

Wajman

et al. 2018

J Assist Reprod Genet

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Purpose Controlled ovarian stimulation is a fundamental part of a successful assisted reproduction treatment, and recognizing patients at risk of a poor response allows the development of targeted research to propose new treatment strategies for this specific group. The objective of this systematic review was to determine risk factors for poor ovarian response (POR) to controlled stimulation in assisted reproduction cycles described in the literature. Methods The primary databases MEDLINE, Cochrane, LILACS, and SciELO were consulted, using specific terms with a restriction for articles in English or Portuguese published in the last 10 years. Results and conclusion Our data suggest that environmental endocrine disruptors, tobacco, genetic mutations, endometriomas, ovarian surgery, chemotherapy, and short menstrual cycles are factors that influence stimulation in assisted reproduction cycles. Further studies are necessary for characterizing patients with prior risk factors.

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Section: Abo Blood Typementioning

confidence: 99%

Risk factors for inadequate response to ovarian stimulation in assisted reproduction cycles: systematic review

Amaral

Ejzenberg

Wajman

et al. 2018

J Assist Reprod Genet

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“…Moreover, a report by WebMD Health News [23], proposed that type O blood is associated with infertility. According to some studies, women with antigen B are more likely to develop DOR [24], and subsequent studies found that ABO blood group had no effect on ovarian reserve or ovarian response [25][26][27][28][29][30]. Lin et al showed that Chinese women with blood type O had less diminished ovarian reserve than women with blood type B and AB, which were more frequently associated with diminished ovarian reserve, whereas blood type A was not associated with ovarian reserve [24].…”

Section: Introductionmentioning

confidence: 99%

Association of ABO blood groups with ovarian reserve: a retrospective cohort study in Chinese Han women younger than 40 years with infertility

Sun

Meng

et al. 2022

J Ovarian Res

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Background Ovarian reserve reflects both the quantity and quality of oocytes available for procreation and is affected by many known and unknown factors. ABO blood type is related to several infertility processes, but it is unclear whether and how ABO blood type affects ovarian reserve. Objective The purpose of the study was to explore the correlation between ABO blood types and ovarian reserve in infertile Chinese Han women under 40 years of age undergoing the in vitro fertilization (IVF)/ intracytoplasmic sperm injection (ICSI)-embryo transfer (IVF/ICSI-ET) treatment. Methods Women aged < 40 years who underwent IVF/ICSI-ET at our institution and had a documented ABO blood type were eligible for this study. In this study, patients were divided into two groups according to the diminished ovarian reserve (DOR) group (AMH < 1.1 ng/mL, AFC < 6) and the non-diminished ovarian reserve (non-DOR) group (AMH ≥ 1.1 ng/mL, AFC ≥ 6). The relationship between ovarian reserve and ABO blood group was determined by correlation analysis. Results In this retrospective cohort study, clinical data were collected from 1690 Chinese Han women treated with IVF/ ICSI-ET in hospital records between April 2019 and March 2020 in the affiliated hospital of Southwest Medical University, located in Luzhou, China. The differences in age, duration of infertility, BMI, FSH, FSH / LH, and p (DOR vs non-DOR) for each parameter (DOR vs non-DOR) were statistically significant, and the differences in LH and E2 were not statistically significant. ABO blood groups were most prevalent in the DOR group with O (143, 34.8%) and A (122, 29.7%) and in the non-DOR group with A (428, 33.5%) and O (419, 32.8%). ABO blood groups were most prevalent in the DOR group with O (n = 57, 30.5%) and A (n = 54, 28.9%) and in the non-DOR group with A (n = 335, 34.0%) and O (n = 323, 32.8%) were the most frequent in the non-DOR group. Conclusions In this retrospective cohort study, we confirmed the lack of a significant association between ABO blood type and ovarian reserve. Further studies are needed to clarify whether there is any prognostic correlation between ABO blood group and ovarian reserve in women undergoing IVF/ICSI-ET.

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“…Some studies have also reported the relationship between the ABO blood group and ovarian reserve, and showed that blood group O is more likely to have diminished ovarian reserve (DOR) [ 9 , 10 ]. Whereas some studies found that women with antigen B are more likely to have DOR [ 11 ], and subsequent studies found that ABO blood group was not related to ovarian reserve or ovarian response [ 12 – 17 ]. Research reports on the relationship between ABO blood group and ovarian hyperstimulation syndrome (OHSS) were also inconsistent [ 18 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

Association of ABO blood groups with ovarian reserve, and outcomes after assisted reproductive technology: systematic review and meta-analyses

Zhao

Yao

Hao

et al. 2021

Reprod Biol Endocrinol

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Background There has been an interest in the relationship between ABO blood groups and infertility. Many studies have investigated the association of ABO blood groups with diminished ovarian reserve (DOR), ovarian hyperstimulation syndrome (OHSS), and outcomes of assisted reproductive technology (ART), with controversial results. Methods A systematic review and meta-analysis was conducted to evaluating the association of ABO blood groups with DOR, OHSS, and outcomes of ART. Results Thirteen studies performed between 2010 and 2018 were included in this meta-analysis. DOR, OHSS, live birth rate (LBR), clinical pregnancy rate (CPR), miscarriage rate (MR) were reported in 9, 2, 4, 3, 2 studies, respectively. The combined results showed similar risk of DOR among individuals with blood group A (RR, 0.98; 95% confidence interval [CI], 0.85, 1.13), B (RR, 0.96; 95% CI, 0.76, 1.20), AB (RR, 1.00; 95% CI, 0.76, 1.30), and non-O (RR, 0.94; 95% CI, 0.79, 1.11) as compared to those with blood group O. Meta-analysis showed that the incidences of OHSS were similar in women with blood group A (RR, 1.05; 95% CI, 0.66, 1.66), B (RR, 1.04; 95% CI, 0.46, 2.35), AB (RR, 0.51; 95% CI, 0.10, 2.56), non-O (RR, 1.02; 95% CI, 0.65, 1.57) with blood group O. As to the clinical outcomes, meta-analysis showed no difference in LBR among individuals with blood group A (RR, 1.27; 95% CI, 0.74, 2.17), B (RR, 1.47; 95% CI, 0.95, 2.29), AB (RR, 1.48; 95% CI, 0.76, 2.90), non-O (RR, 1.28; 95% CI, 0.83, 1.98) when compared to those with blood group O. Similarly, the results also found that there were no difference in CPR and MR between women with blood A (CPR: RR, 1.12), B (CPR: RR, 1.08), AB (CPR: RR, 1.05), non-O (CPR: RR, 1.05; MR: RR, 0.94) and blood group O. Conclusions ABO blood groups may not be associated with DOR, OHSS, LBR, CPR, and MR of ART. Infertility and ART outcomes are influenced by multiple factors. Blood groups should not be taken into account excessively during diagnosis and treatment of infertile women.

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ABO blood group and ovarian reserve: a meta-analysis and systematic review

Cited by 9 publications

References 34 publications

Risk factors for inadequate response to ovarian stimulation in assisted reproduction cycles: systematic review

Risk factors for inadequate response to ovarian stimulation in assisted reproduction cycles: systematic review

Association of ABO blood groups with ovarian reserve: a retrospective cohort study in Chinese Han women younger than 40 years with infertility

Association of ABO blood groups with ovarian reserve, and outcomes after assisted reproductive technology: systematic review and meta-analyses

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