ABO blood group and the risk of aortic disease: a nationwide cohort study

Abstract

ObjectivesTo analyse the association between ABO blood group and aortic disease using data on blood donors and transfused patients from Sweden.DesignThis was a retrospective study using data from the Swedish portion of the Scandinavian Donations and Transfusions Database. The association between ABO blood group and aortic disease was analysed using log-linear Poisson regression models and presented as incidence rate ratios (IRRs).SettingSwedish population-based study.ParticipantsThe study cohort consisted of 1 164 561 Swedish blood donors and 961 637 transfused patients with a combined follow-up time of 29 390 649 person-years.Primary and secondary outcome measuresIRRs of aortic events (ie, aortic aneurysms and/or aortic dissections) in relation to patient blood group.ResultsA total of 20 684 aortic events occurred during the study period. Non-O donors and patients had similar incidence of aortic events when compared with blood group O donors and patients with an IRR of 0.98 (95% CI, 0.93–1.04) and 1.00 (95% CI, 0.97–1.03), respectively. There were no differences between non-O and blood group O individuals when aortic dissections and aortic aneurysms were analysed separately. Blood group B conferred a lower risk of aortic aneurysms in the patient cohort when compared with blood group O (IRR, 0.90; 95% CI, 0.85–0.96).ConclusionsIn the present study, there were no statistically significant associations between ABO blood group and the risk of aortic disease. A possible protective effect of blood group B was observed in the patient cohort but this finding requires further investigation.

B blood group is related to decreased risk of incidence and severity of coronary artery disease in elderly adults with hypertension

“…It is reported that patients with B blood group are less likely to develop pancreatic neuroendocrine tumors and other types of pancreatic masses in Chinese population [11]. Meanwhile, a nationwide cohort study suggested that B blood group conferred a lower risk of aortic aneurysms when compared with O blood group [12]. Individuals with B blood group account for approximately 25% of Chinese population.…”

Blood group B and decreased risk of coronary artery disease in hypertensive elderly.

“…In addition, it has been reported that patients with the blood group B are less likely to develop pancreatic neuroendocrine tumors and other pancreatic masses in the Chinese population 11 . Meanwhile, a nationwide cohort study suggested that blood group B conferred a lower risk of aortic aneurysms than the blood group O 12 . A meta-analysis including 241.868 Hepatitis B virus (HBV)-infected subjects and 6.487.481 uninfected subjects also found that blood group B was associated with a lower risk of HBV infection (RR=0.92, 95% CI 0.86 to 0.98) 13 .…”