ABO Blood Group Antigens as a Model of Studying Protein-Protein Interactions

Abstract

This work presents a research of intermolecular interactions on the example of the antigen antibody interactions of the ABO system. This model could be successfully used in the future due to the lack of knowledge in the area of the ABO antigen's behavior as a biomolecule and the integration of these structures into chain of metabolic processes in a human being. Using computer PASS system ("in silico" research), we describe the possible biological effects of pyruvate, lactate, and antigen determinants A and B. Glycoproteins A and B are very perspective to study as biological active connectors due to the wide range of their biological effects. The obtained knowledge proves that ABO antigen, as well as other glycoprotein conjugates, could play an important role in intercellular adhesion and signal transmission, which could be used in perspective in personalized medicine, target therapy, and evaluation of lab results in clinical practice.

Association of ABO and Rhesus Blood Types with Transfusion-Transmitted Infections (TTIs) Among Apparently Healthy Blood Donors at Bahir Dar Blood Bank, Bahir Dar, North West, Ethiopia: A Retrospective Cross-Sectional Study

“…Along with their expression on red blood cells, ABO blood group antigens are also found on other cells and tissues like epithelium, sensory neurons, platelets, the vascular endothelium, breast ductal and lobular cells, and some malignant cells. 1 Among the blood group antigens identified, ABO and Rhesus (Rh) are the most widely studied. Besides their clinical significance in the blood transfusion and compatibility, ABO and Rh blood group antigens were found to be associated with many non-infectious and infectious diseases.…”