ABO Blood Groups in Relation to Ischaemic Heart Disease

Bronte‐Stewart, B.; Botha, Michiel; Krut, L. H.

doi:10.1136/bmj.1.5293.1646

Cited by 83 publications

(38 citation statements)

References 11 publications

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“…To the best of our knowledge, this is the first study to provide precise estimates of venous thrombosis and arterial disease risk with ABO blood groups using a large cohort of blood donors, and our results are consistent with previous reports. 3,[21][22][23] However, a recent meta-analysis reported higher relative risk estimates for both venous and arterial events compared with our study, although the included studies demonstrate a high degree of statistical heterogeneity. 4 Scattered hospital-based reports using small samples have previously shown inconsistent results attributable to ABO blood group on the risk of thromboembolic events after surgery, [24][25][26] trauma, 27,28 cancer, 29,30 and diabetes mellitus, 31 and these studies show a marked variation in study quality.…”

Section: Discussioncontrasting

confidence: 52%

ABO Blood Group and Risk of Thromboembolic and Arterial Disease

et al. 2016

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T he clinical importance of ABO blood groups extends beyond the direct implications on transfusion and organ-transplantation compatibility. It is increasingly being recognized that individuals with non-O blood groups may be at elevated risk of venous thromboembolic events (VTEs), myocardial infarction, cerebrovascular ischemic events, and peripheral vascular disease compared with individuals with blood group O.1-4 This risk increase has been attributed to higher concentrations of factor VIII and von Willebrand factor. 5,6 Approximately 70% of the variation in the levels of these factors is genetically determined, and 30% of the explained variation is attributable to ABO blood groups. 7 In addition, Sode and colleagues 8 have shown that ABO blood type has an additive effect on the risk of VTE when combined with factor V Leiden R506Q and prothrombin G20210A mutations. A recent genome-wide association study has identified variants in the ABO locus that are associated with VTE, 9 providing additional clues to the genetic influence on thromboembolic risk. Available epidemiological data, however, fail to provide a coherent picture of the association between ABO blood group and thromboembolic risk. First, there is a Background-ABO blood groups have been shown to be associated with increased risks of venous thromboembolic and arterial disease. However, the reported magnitude of this association is inconsistent and is based on evidence from smallscale studies. Methods and Results-We used the SCANDAT2 (Scandinavian Donations and Transfusions) database of blood donors linked with other nationwide health data registers to investigate the association between ABO blood groups and the incidence of first and recurrent venous thromboembolic and arterial events. Blood donors in Denmark and Sweden between 1987 and 2012 were followed up for diagnosis of thromboembolism and arterial events. Poisson regression models were used to estimate incidence rate ratios as measures of relative risk. A total of 9170 venous and 24 653 arterial events occurred in 1 112 072 individuals during 13.6 million person-years of follow-up. Compared with blood group O, non-O blood groups were associated with higher incidence of both venous and arterial thromboembolic events. The highest rate ratios were observed for pregnancy-related venous thromboembolism (incidence rate ratio, 2.22; 95% confidence interval, 1.77-2.79), deep vein thrombosis (incidence rate ratio, 1.92; 95% confidence interval, 1.80-2.05), and pulmonary embolism (incidence rate ratio, 1.80; 95% confidence interval, 1.71-1.88). Conclusions-In

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Section: Discussioncontrasting

confidence: 52%

ABO Blood Group and Risk of Thromboembolic and Arterial Disease

et al. 2016

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“…24 A higher frequency of A and B groups and a paucity of group O patients was found in those with prior MI in a South African case-controlled study. 25 In the Hoorn study 26 , non-O blood group was associated with a 2-fold increased cardiovascular mortality compared with blood group O. In another study by Amirzadegan et al, 27 blood groups in patients who had undergone CABG was compared with data derived from the blood transfusion organization of Iran and concluded that the blood group could not serve as a risk factor for CAD.…”

Section: Discussionmentioning

confidence: 99%

Association of ABO blood group with CAD in patients undergoing CAG in Cardiology Department of Dhaka Medical College and Hospital

et al. 2015

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There are many reports regarding association between ABO and Rhesus blood groups and coronary artery disease. This study has been designed to see the association of ABO blood group with coronary artery disease in patient who were admitted in Cardiology Department of Dhaka Medical College and Hospital and undergoing coronary angiography. A total of 680 patients were studied in this retrospective study. ABO blood group, gender and standard cardiovascular risk factors were determined. In our study 17.5% of the study population were female with mean age of 49.94±10.37 years and 82.5% were male with a mean age 49.68±10.45 years . Most of the patients belonged to blood group B (33.4%) .Our results demonstrated the prevalence of CAD in blood group B is much higher than other blood groups which is in contrast with other studies in few other countries including one study done on small groups of people in Bangladesh. Geographical distribution may explain the variation in results among countries.University Heart Journal Vol. 10, No. 2, July 2014; 81-84

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“…An association between ABO blood group and thrombosis risk has long been known [34,35] but the associated mechanisms are unclear [36]. Specifically, blood group non-O has been associated with increased risk for venous thrombosis [37,38].…”

Section: Discussionmentioning

confidence: 99%

The Status of Thrombophilic Defects and Non-O Blood Group as Risk Factors for Gestational Vascular Complications among Tunisian Women

Klai¹,

Fekih-Mrissa²,

Rachdi

et al. 2010

Acta Haematol

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Aims: Our objectives were to assess inherited thrombophilia and non-O blood group for the risk of gestational vascular complications among the Tunisian population. Methods: This study comprised 203 test subjects with adverse pregnancy outcomes including recurrent pregnancy loss, intra-uterine growth retardation, pre-eclampsia and placental abruption. Each subgroup was matched with 100 controls and analyzed separately. All patients were evaluated for factor V Leiden, factor II G20210A mutations and for non-O blood group. Protein S, protein C and antithrombin levels were determined and deficiencies noted. Results: The factor V Leiden mutation, non-O blood group and protein C deficiency had the highest incidences among patients both as a whole and in the 4 subgroups. The factor II G20210A mutation, protein S and antithrombin deficiencies were not statistically significant risk factors. Conclusion: Our results provide evidence for a significant association between the factor V mutation and placental abruption. Furthermore, we found that this and the non-O blood group independently increased the risk for intra-uterine growth retardation in our population.

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ABO Blood Groups in Relation to Ischaemic Heart Disease

Cited by 83 publications

References 11 publications

ABO Blood Group and Risk of Thromboembolic and Arterial Disease

ABO Blood Group and Risk of Thromboembolic and Arterial Disease

Association of ABO blood group with CAD in patients undergoing CAG in Cardiology Department of Dhaka Medical College and Hospital

The Status of Thrombophilic Defects and Non-O Blood Group as Risk Factors for Gestational Vascular Complications among Tunisian Women

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