ABO blood type and clinical characteristics of patients with ulcerative colitis: A hospital-based study in central Taiwan

Abstract

Background The variations in ABO blood groups are reported to be associated with multiple disorders, including ulcerative colitis (UC). We aimed to investigate the distribution of ABO blood groups in UC patients and explore its impact on disease severity. Methods We retrospectively collected 129 UC patients diagnosed at our hospital between January 2000 and November 2019. Clinical characteristics, ABO blood groups, and operation rates were analyzed. Results The mean diagnostic age of patients was 38.97 years. Males accounted for the majority of all patients (62.8%). Of 129 patients, 43 (33.3%) were blood type O, 41 (31.8%) were blood type A, 38 (29.5%) were blood type B, and 7 (5.4%) were blood type AB. Although our patients had higher ratio of blood type A comparing our general population, there was no statistically significant association of ABO blood types distribution between these two groups (p = 0.1906). In the subgroup analysis, there were no significant difference of disease locations and operation rates between different ABO blood groups. Furthermore, blood type A patients had higher serum hemoglobin (Hb) levels compared to blood type O patients (13.31 g/dL vs. 12.30 g/dL, p = 0.0347). Blood type A patients had lower serum erythrocyte sedimentation rate (ESR) levels compared to blood type O patients (12.46 mm/hour vs. 21.5 mm/hour, p = 0.0288). Blood type O had higher serum ESR levels compared to non-O groups (p = 0.0228). In the ABO blood groups and mean diagnostic age (≤ 40 years or > 40 years), there were no statistically significant difference between these two age groups, p = 0.5515. Conclusions Our results showed ABO blood groups are not associated with UC in spite of a higher ratio of blood type A in our patients. Blood type O patients had higher serum ESR levels; however, blood type A patients had higher Hb levels.

ABO blood grouping with negative or positive rhesus factors and relation to autoimmune diseases

“…In Table 2 there were also many research studies that discussed and explored the relationship between blood grouping and autoimmune diseases there was no significant relation between blood types and 2021) all these researchers explained that there was no relation between autoimmune diseases and blood types (1,20,21). Also, a research study by Lai et al (2022) explaining ulcerative colitis showed no association between blood type and ulcerative colitis that type A has high baseline hemoglobin and type O has higher baseline ESR levels [13,14]. Related to psoriatic arthritis cross-sectional and clinical and laboratory research done the result showed that there was no significant relation between psoriatic arthritis and blood grouping [15,16].…”

ABO Blood Type and Clinical Characteristics Among Japanese Patients With Ulcerative Colitis

“…A study from Taiwan involving 129 UC patients found that there was no association between ABO blood type and UC, even though blood type A was more prevalent. Patients with blood type O had higher erythrocyte sedimentation rate levels, whereas those with blood type A had higher hemoglobin levels [ 12 ].…”

“…Second, the sample size may have been too small to accurately assess the relationship between ABO blood type and clinical outcomes. Considering the poor clinical outcomes (operation) in O blood type (6.98%) and non-O blood type (4.65%) [ 12 ], and assuming a detection rate of 75% (two-tailed test, p < 0.05), the calculated sample size was 1,400. Third, the cohort had a high rate of exclusion due to missing data.…”

“…The frequency of ABO blood type was not associated with the onset of UC [ 11 ]. A study in Taiwan found no association between ABO blood type and clinical characteristics of UC [ 12 ]. Therefore, the present study aimed to investigate the association between ABO blood type and clinical characteristics including clinical outcomes in Japanese patients with UC.…”

Radiation Exposure among Patients with Inflammatory Bowel Disease: A Single-Medical-Center Retrospective Analysis in Taiwan

“…Although these previous studies show an increased risk of cumulated radiation exposure among IBD patients [ 7 , 8 , 9 , 10 , 11 ], no previous report addressed this issue among the Taiwanese population. As the incidence and prevalence of IBD are increasing in Taiwan [ 12 , 13 , 14 , 15 , 16 , 17 , 18 ], it is essential to understand the pattern of radiation exposure in this growing population. Therefore, we conducted this study to estimate the radiation exposure and analyze possible risk factors associated with radiation exposure among Taiwanese IBD patients.…”