ABO groups can play a role in susceptibility and severity of COVID-19

Samra, Saad Rabie; Habeb, M.; Nafae, Ramadan M.

doi:10.1186/s43168-020-00051-w

Cited by 16 publications

(20 citation statements)

References 7 publications

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“…It is not yet clear which blood type is most likely to be susceptible to COVID-19. Some studies considered that people with blood type A to be the most susceptible to the disease, and people with blood type O are less likely to develop the disease [ 13–15 , 17–20 , 24 , 27–55 ]. But other studies reported conflicting results [ 22 , 23 , 56 , 57 ], and some did not find a significant relationship between blood type and COVID-19 [ 16 , 21 , 58–60 ].…”

Section: Discussionmentioning

confidence: 99%

“…But other studies reported conflicting results [ 22 , 23 , 56 , 57 ], and some did not find a significant relationship between blood type and COVID-19 [ 16 , 21 , 58–60 ]. Moreover, studies reported that individuals with Rh- blood type had a lower risk of infection, intubation and death, and cases with Rh+ were more sensitive to COVID-19 [ 24 , 27–29 , 56 , 57 ]. However, a study from Iran did not find any relation between COVID-19 and Rh type [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

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Association Between Blood Groups and COVID-19 Outcome in Iranian Patients

et al. 2021

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Aim: Many factors have been speculated to explain the COVID-19 complex clinical phenotype. Due to the inconsistent data published on blood groups and COVID-19, we conducted a study on Iranian patients to further assess this association. Materials & methods: This retrospective study was conducted on data collected from confirmed COVID-19 hospitalized patients during March and December 2020 in a referral hospital for COVID-19, 5 Azar Hospital, Gorgan, north of Iran. A total of 1554 confirmed COVID-19 cases were enrolled in the study with blood group (ABO and Rh), demographic, and clinical data available. Results: Of 1554 patients, 1267 and 287 cases had recovered and deceased (due to COVID-19) outcomes, respectively. Most of the cases had O+ (29.6%), the least number had AB- (0.5%), and most of the deceased cases had O+ blood types (31.4%). Logistic regression analysis revealed that groups A- and B- had higher and groups B+, AB+, O+ and O- had lower odds of death than the A+ group. Conclusion: This study indicates that blood types may be related to the clinical outcome of COVID-19. Further studies with a large cohort for multiple people are required to validate this association.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Association Between Blood Groups and COVID-19 Outcome in Iranian Patients

et al. 2021

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“…In contrast, blood group O has the slightest chance of developing the novel coronavirus. No correlation existed between ABO blood groups with the severity of SARS CoV-2 infection (Samra et al, 2021) .…”

Section: Discussionmentioning

confidence: 88%

The prevalence of comorbidities and associated risk factors among Covid-19 deceased in Mizoram, India

Lalchhuanawma¹,

Sanghi²,

Chawngthu³

2021

ijrps

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The WHO declaration of the novel coronavirus (Covid-19) caused by SARS-CoV-2 as a pandemic has raised serious questions and has since been a global health concern. Data on the clinical characteristics, laboratory findings of deceased covid-19 individuals are sparse. The study analyzed the clinical and laboratory profiles of Covid-19 deceased in Zoram Medical College Mizoram, India. We gathered information from the Mizoram Government Covid-19 portal and hospital medical record section. The study examined eight confirmed Covid-19 deaths out of the total nine Covid-19 fatalities reported in Mizoram as of February 14, 2021. The decedents' mean age was 62.88 (±18.659) years; among them, 87.5% were males, and blood group B was associated with half of the deceased. In Mizoram, the case fatality rate, crude death rate, and recovery rate were 0.2%, 7.27 per million, and 99.40%, respectively, with 3547 cases per million. The median length of hospital and ICU stay (between admission and death) was 15.5 and 11 days. The common presenting symptoms were fever (75%), shortness of breath (62.5%), cough/ sore throat (50%). Hypertension (62.5%) and diabetes mellitus (62.5%) were the two most prevalent comorbidities, followed by cardiovascular diseases (25%). The concurrence of hypertension and diabetes mellitus constituted 87.5%, 75% of the decedents reported the presence of at least one of the comorbidities. The two most common complications were an acute respiratory failure (87.5%) and cardiovascular complications (87.5%). Increased risk of severe Covid-19 disease increases with advanced age (>60 years), gender (male), and underlying comorbidities.

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“…Difference between blood group AB versus O was highly statistically significant p<0.001) [33]. Some studies have reported that non-O blood group individuals are at higher risk of developing COVID-19 in comparison to O blood group and they have postulated that this is either due to natural antibodies against blood group antigens acting as a part of innate immune response to neutralize viral particles or alternatively, blood group antigens maybe acting as additional receptors for the virus and individuals who are capable of expressing these antigens on epithelial cells, would possibly have a high propensity to be affected by SARS-CoV-2 [34][35][36]. In our study, we found a higher median SARS CoV-2 antibody levels in donors in age group of 41-50 years compared with other age groups in both the centres.…”

Section: Discussionmentioning

confidence: 99%

COVID-19 Convalescent Plasma Donor Characteristics: Correlation with Blood Group, Age, Gender, Symptoms and their Association with SARS CoV-2 Antibody Levels: A Bi-centric Study from India

Dogra

Setia

Pathak

et al. 2021

IJTDH

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Background: Understanding demographics and collection characteristics of Convalescent Plasma (CP) donors is the corner stone for maintaining a viable inventory of high titre CP products in an acute-crisis setting. The Specific objectives of this study were to find a correlation between SARS-CoV-2 antibody level with age, gender and blood group in CP donors. Materials and Methods: An observational, retrospective study was conducted at blood centres of two multispecialty hospitals in Delhi from 1st November 2020 to 31st January 2021. 936 consenting COVID-19 recovered individuals were screened and underwent a medical interview for eligibility for CP donation from both blood centres, of which 750 qualified for CP collection. 400/ 750 (53.3%) CP donations were from centre A and 350/750 (46.7%) were from centre B. Donor characteristics data for both centres was retrieved from the blood bank donor management database and records from both the centres. Results: The results of this study revealed that majority were males 727 (96.93%) and 23 (3.07%) were females with mean age was 35.09±8.7 years. 41-50 years showed higher median SARS-CoV-2 antibodies. Of the 936 donors screened for CP collection, 186 donors got deferred due to various reasons, resulting in a mean deferral rate of 19.87%. The commonest reason (15.05%) was absence of detectable/low SARS CoV-2 antibodies. Group-wise median antibody levels were AB>B>A>O at both centres. Moderate correlation (correlation coefficient =0.721) between number of symptoms and SARS CoV-2 antibody levels was observed; high symptom scores showed high SARS CoV-2 antibodies values (correlation coefficient=0.721; p < 0.00001). The individual symptom-wise predictors like fever (p= 0.002) and acute gastroenteritis (GE) or (GE-like syndrome) (p < 0.001) were positive predictors for high SARS CoV-2 antibodies. Cold (p = 0.006) and absence of symptoms (p = 0.060) were negative predictors. To summarize a collective significant effect exists between the symptoms and SARS CoV-2 antibody levels. Donors with symptoms like fever and GE or GE like syndrome showed significantly higher SARS Cov-2 antibodies. Female donors as compared to male donor, donors in age group of 41-50 years and donors with blood group AB compared with other groups had higher median levels of SARS CoV-2 antibodies. Conclusion: Awareness of CP donor characteristics, post-screening deferrals, and correlates of antibody values with age, symptoms and blood group will help improve collection outcomes and give better preparedness for future recurrent waves due to evolution of more virulent SARS-CoV-2 strains and fill treatment gap till availability of more specific treatment.

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ABO groups can play a role in susceptibility and severity of COVID-19

Cited by 16 publications

References 7 publications

Association Between Blood Groups and COVID-19 Outcome in Iranian Patients

Association Between Blood Groups and COVID-19 Outcome in Iranian Patients

The prevalence of comorbidities and associated risk factors among Covid-19 deceased in Mizoram, India

COVID-19 Convalescent Plasma Donor Characteristics: Correlation with Blood Group, Age, Gender, Symptoms and their Association with SARS CoV-2 Antibody Levels: A Bi-centric Study from India

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