ABO(H) blood group antigens of the human erythrocyte membrane: Contribution of glycoprotein and glycolipid

Mehta, Narendra G.

doi:10.1007/bf01869002

Cited by 14 publications

(2 citation statements)

References 63 publications

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“…Since the UEA-1 signal was mainly observed on the cellular membrane, we hypothesized that glycolipids are candidates for UEA-1 detection. It is well known that blood-group-ABH antigens localize to glycoproteins and glycolipids in erythrocytes (Mehta 1980; Schenkel-Brunner 1980), and H antigens are stained by UEA-1 due to the presence of α-fucose residues (Audette et al 2000). H antigens are also observed in rat taste buds (Smith et al 1994; Pumplin et al 1999; Wakisaka 2005; Feng et al 2014).…”

Section: Discussionmentioning

confidence: 99%

Ulex Europaeus Agglutinin-1 Is a Reliable Taste Bud Marker for In Situ Hybridization Analyses

Yoshimoto

Okada

Kishi³

et al. 2015

J Histochem Cytochem.

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Taste signals are received by taste buds. To better understand the taste reception system, expression patterns of taste-related molecules are determined by in situ hybridization (ISH) analyses at the histological level. Nevertheless, even though ISH is essential for determining mRNA expression, few taste bud markers can be applied together with ISH. Ulex europaeus agglutinin-1 (UEA-1) appears to be a reliable murine taste bud marker based on immunohistochemistry (IHC) analyses. However, there is no evidence as to whether UEA-1 can be used for ISH. Thus, the present study evaluated UEA-1 using various histochemical methods, especially ISH. When lectin staining was performed after ISH procedures, UEA-1 clearly labeled taste cellular membranes and distinctly indicated boundaries between taste buds and the surrounding epithelial cells. Additionally, UEA-1 was determined as a taste bud marker not only when used in single-colored ISH but also when employed with double-labeled ISH or during simultaneous detection using IHC and ISH methods. These results suggest that UEA-1 is a useful marker when conducting analyses based on ISH methods. To clarify UEA-1 staining details, multi-fluorescent IHC (together with UEA-1 staining) was examined, resulting in more than 99% of cells being labeled by UEA-1 and overlapping with KCNQ1-expressing cells.

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Section: Discussionmentioning

confidence: 99%

Ulex Europaeus Agglutinin-1 Is a Reliable Taste Bud Marker for In Situ Hybridization Analyses

Yoshimoto

Okada

Kishi³

et al. 2015

J Histochem Cytochem.

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“…Glycolipids from plasma, some of which express ABH antigens, can be inserted into lipid carriers . The extent to which ABH‐expressing glycolipids become incorporated into lipoproteins as previously described for RBCs , where they could potentially affect the clearance of these particles, remains to be fully characterized.…”

Section: Abo and General Metabolismmentioning

confidence: 98%

Biologic roles of the ABH and Lewis histo‐blood group antigens part II: thrombosis, cardiovascular disease and metabolism

Stowell

2019

Vox Sanguinis

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The ABH and Lewis antigens were among the first of the human red blood cell polymorphisms to be identified and, in the case of the former, play a dominant role in transfusion and transplantation. But these two therapies are largely twentieth‐century innovations, and the ABH and related carbohydrate antigens are not only expressed on a very wide range of human tissues, but were present in primates long before modern humans evolved. Although we have learned a great deal about the biochemistry and genetics of these structures, the biological roles that they play in human health and disease are incompletely understood. This review and its companion, which appeared in a previous issue of Vox Sanguinis, will focus on a few of the biologic and pathologic processes which appear to be affected by histo‐blood group phenotype. The first of the two reviews explored the interactions of two bacteria with the ABH and Lewis glycoconjugates of their human host cells, and described the possible connections between the immune response of the human host to infection and the development of the AB‐isoagglutinins. This second review will describe the relationship between ABO phenotype and thromboembolic disease, cardiovascular disease states, and general metabolism.

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Tumor-Associated Blood Group Antigen Expressions and Immunoglobulins Associated with Tumors

Anderson

Davis

Venegas

1988

The Molecular Immunology of Complex Carbohydrates

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ABO(H) blood group antigens of the human erythrocyte membrane: Contribution of glycoprotein and glycolipid

Cited by 14 publications

References 63 publications

Ulex Europaeus Agglutinin-1 Is a Reliable Taste Bud Marker for In Situ Hybridization Analyses

Ulex Europaeus Agglutinin-1 Is a Reliable Taste Bud Marker for In Situ Hybridization Analyses

Biologic roles of the ABH and Lewis histo‐blood group antigens part II: thrombosis, cardiovascular disease and metabolism

Tumor-Associated Blood Group Antigen Expressions and Immunoglobulins Associated with Tumors

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