2016
DOI: 10.1542/peds.2015-2830
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AbobotulinumtoxinA for Equinus Foot Deformity in Cerebral Palsy: A Randomized Controlled Trial

Abstract: BACKGROUND: Although botulinum toxin is a well-established treatment of focal spasticity in cerebral palsy, most trials have been small, and few have simultaneously assessed measures of muscle tone and clinical benefit.

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Cited by 61 publications
(96 citation statements)
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References 21 publications
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“…12 The results of these secondary and exploratory analyses of goal attainment support the overall findings and confirm that treatment with abobotulinumtoxinA improved the ability of patients to achieve their treatment goals versus placebo.…”
Section: Discussionsupporting
confidence: 68%
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“…12 The results of these secondary and exploratory analyses of goal attainment support the overall findings and confirm that treatment with abobotulinumtoxinA improved the ability of patients to achieve their treatment goals versus placebo.…”
Section: Discussionsupporting
confidence: 68%
“…12 Institutional review boards at the participating sites approved the protocol, and the trial was executed in accordance with the Declaration of Helsinki and International Conference on Harmonization Good Clinical Practice Guidelines.…”
Section: Methodsmentioning
confidence: 99%
See 1 more Smart Citation
“…It is clear that current guidelines restrict the use of botulinum toxin, supporting intervention only for cerebral palsy and upper limb post‐stroke spasticity. For cerebral palsy, only adults who were treated as children can receive botulinum toxin, in spite of the fact that current research and clinical experience suggest that adult patients with cerebral palsy respond well to the toxin 12 . For instances of stroke, while upper limb spasticity post‐stroke can be treated (minimally), post‐stroke lower limb spasticity and foot dystonia are excluded, although the reduction of both is critical to walking 13 …”
Section: Pbs and Guidelinesmentioning
confidence: 99%
“…For cerebral palsy, only adults who were treated as children can receive botulinum toxin, in spite of the fact that current research and clinical experience suggest that adult patients with cerebral palsy respond well to the toxin. 12 For instances of stroke, while upper limb spasticity post-stroke can be treated (minimally), post-stroke lower limb spasticity and foot dystonia are excluded, although the reduction of both is critical to walking. 13 Unfortunately, the PBS guidelines reflect outdated information about the treatment of spasticity in either the upper or lower limbs following stroke (and other neurological disorders).…”
Section: Pbs and Guidelinesmentioning
confidence: 99%