Abordagem química e toxicidade em modelo zebrafish de geoprópolis de melipona fasciculata Smith

Abstract

Melipona fasciculata Smith, native to Maranhão, is a stingless bee that produces honey, wax and geopropolis, which is made up of resinous material collected from plants, salivary secretions, wax and clay or earth. One species is widely cultivated in the state of Maranhão, mainly in the Baixada and Cerrado regions, commercially created in groups of colonies, called meliponários, that produce a meliponicultura. Studies show that a geopropolis has biological activities such as antimicrobial, leishmanicidal, antioxidant, anthelmintic, antiproliferative, showing to be a promising natural product for further research. Thus, the article aims to verify the chemical profile of the geographic extracts of the Melipona fasciculated Smith and to investigate the toxicity of the extracts against the zebrafish model. As samples collected directly from meliponary hives in the municipality of Pinheiro and Viana, in the state of Maranhão. They were dried, selected, extracted by maceration with 70% ethyl alcohol for 48 hours, obtaining as extractive solutions, which were filtered and concentrated in the rotary and lyophilized evaporator, obtaining the EHGP and EHGV. The chemical composition was

Cytotoxicity and Pro-Apoptotic, Antioxidant and Anti-Inflammatory Activities of Geopropolis Produced by the Stingless Bee Melipona fasciculata Smith

“…No significant toxic effects were observed, reinforcing the safety of the geopropolis extract and emphasizing its ability to inhibit cell proliferation, promoting its antitumor activity (Figure 4). Our investigations regarding the toxic effects of the extract corroborate Barboza et al [49], who evaluated acute EHGV and EHGP toxicity in a zebrafish toxicity model and reported very low toxicity.…”