Abordaje multidisciplinar de un tumor phyllodes maligno de mama en una mujer de 16 años

Malon, S.; Batalla, Pau Nicolau; Capdevila, Berta Fabregó; Silva, Rodrigo Alcántara da; Heras, Ivonne Vázquez de las; Bouza, Elena María Rodríguez; Tomás, Maria del Mar Vernet

doi:10.1016/j.senol.2020.01.001

Cited by 1 publication

(4 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Subsequently, Lee, in 1931, described a case of metastatic behavior, which currently it has the ability to metastasize in up to 9% of reported cases. The average age of presentation is 40-45 years, however, it is the most frequent malignant breast tumor in adolescents [1,3,4] hence the importance of establishing a differential diagnosis from the beginning.…”

Section: Discussionmentioning

confidence: 99%

“…Multiple studies have reported an initial histopathological diagnosis of fibroadenomas in patients under 18 years of age and, after definitive resection, a diagnosis of malignant PT was obtained [4][5][6][7]. For this reason, in lesions with particular behaviors (such as considerable increase in size in short periods of time, multilobulated lesions or with increased vascularity) we consider that an intraoperative biopsy should be performed in order to avoid false negatives, which was not performed in our case due to the lack of an pathological JFAG is the main cause of unilateral macromastia and breast asymmetry in adolescents.…”

Section: Discussionmentioning

confidence: 99%

“…Traditionally, the etiology has been related to increased estrogen levels or increased hormone receptors [8,9]. On the other hand, PTs appear as rounded tumors, generally single, well circumscribed and lobulated, of variable sizes, from a few centimeters to well-defined, painless, mobile lesions that occupy the entire breast [1,[4][5][6][7].…”

Section: Discussionmentioning

confidence: 99%

“…The microscopic appearance of the fibroadenoma is quite typical: proliferation of the double canalicular epithelium is observed, which is elongated and deformed by the simultaneous growth of the loose connective component, designing stellar, linear or arciform figures. On the other hand, PTs are mixed (stromal and epithelial), with an intracanalicular growth pattern reminiscent of fibroadenoma, but with a spindle-shaped and more cellular mesenchymal component, which forms lobulated leaflike masses (foliaceous) and are covered by bistratified epithelium with a basal layer of myoepithelial cells and an external luminal layer, being classified depending on their stromal cellularity, mitotic activity, and cellular atypia into benign, borderline, and malignant (cystosarcoma phyllodes) [1][2][3][4][5][6][7].…”

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Untitled

2024

IJSST

View full text Add to dashboard Cite

Fibroadenoma is the most common benign fibroepithelial lesion of the breast in young women, accounting for around 90% of solid lesions of the gland in adolescence. However, juvenile giant fibroadenoma is a rare breast condition that occurs in women under 18 years of age. Due to the similarity of the characteristics of juvenile giant fibroadenoma and phyllodes tumor, both lesions characterized by rapid growth, it is important to establish the differential diagnosis of both pathologies when one of them is suspected, in order to guarantee the most appropriate therapeutic attitude to follow. A 14-year-old woman with no family or personal history of interest, who consulted due to a clinical picture characterized by breast asymmetry secondary to progressive growth of the left breast of 5 months of evolution. An ultrasound-guided core needle biopsy was performed that reported giant juvenile fibroadenoma. Lumpectomy was performed. Histopathological diagnosis compatible with juvenile giant fibroadenoma of the left breast. Based on our case and on the reviewed bibliography, we recommend an early differential diagnosis, as well as an accurate one, and surgical treatment of cases of juvenile giant fibroadenoma. The surgical tactics and technique depend on the age at the time of diagnosis, the clinical and imaging characteristics of the mammary gland and the tumor, as well as the wishes of the patient in question.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%