Abordaje terapéutico de la enfermedad de Crohn: posibles paralelismos con la hidradenitis supurativa

Lama, Y. González; Marín-Jiménez, Ignacio

doi:10.1016/s0001-7310(17)30002-9

Cited by 3 publications

(2 citation statements)

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“…It has already become one of the major gastroenterological diseases during the past decades. 2 Although the exact etiology remains unknown, multiple factors, including genetic susceptibility, immune malfunction, environmental factors, and mucosal-associated gut microbiota dysbiosis, have been suggested to contribute to the pathogenesis of ulcerative colitis. 3−5 Gut microbiota imbalance in patients with ulcerative colitis is often accompanied by reduced biodiversity, altered gut microbiota composition, and impaired intestinal integrity.…”

Section: Introductionmentioning

confidence: 99%

“…Its incidence and prevalence are constantly increasing worldwide. It has already become one of the major gastroenterological diseases during the past decades . Although the exact etiology remains unknown, multiple factors, including genetic susceptibility, immune malfunction, environmental factors, and mucosal-associated gut microbiota dysbiosis, have been suggested to contribute to the pathogenesis of ulcerative colitis. − …”

Section: Introductionmentioning

confidence: 99%

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Bergenin Alleviates Ulcerative Colitis By Decreasing Gut Commensal Bacteroides vulgatus-Mediated Elevated Branched-Chain Amino Acids

Huang,

Chen,

Zeng

et al. 2024

J. Agric. Food Chem.

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Ulcerative colitis is closely associated with the dysregulation of gut microbiota. There is growing evidence that natural products may improve ulcerative colitis by regulating the gut microbiota. In this research, we demonstrated that bergenin, a naturally occurring isocoumarin, significantly ameliorates colitis symptoms in dextran sulfate sodium (DSS)-induced mice. Transcriptomic analysis and Caco-2 cell assays revealed that bergenin could ameliorate ulcerative colitis by inhibiting TLR4 and regulating NF-κB and mTOR phosphorylation. 16S rRNA sequencing and metabolomics analyses revealed that bergenin could improve gut microbiota dysbiosis by decreasing branched-chain amino acid (BCAA) levels. BCAA intervention mediated the mTOR/p70S6K signaling pathway to exacerbate the symptoms of ulcerative colitis in mice. Notably, bergenin greatly decreased the symbiotic bacteria Bacteroides vulgatus (B. vulgatus), and the gavage of B. vulgatus increased BCAA concentrations and aggravated the symptoms of ulcerative colitis in mice. Our findings suggest that gut microbiota-mediated BCAA metabolism plays a vital role in the protective effect of bergenin on ulcerative colitis, providing novel insights for ulcerative colitis prevention through manipulation of the gut microbiota.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Bergenin Alleviates Ulcerative Colitis By Decreasing Gut Commensal Bacteroides vulgatus-Mediated Elevated Branched-Chain Amino Acids

Huang,

Chen,

Zeng

et al. 2024

J. Agric. Food Chem.

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Hidradenitis supurativa perianal o enfermedad de Crohn perianal: diagnóstico diferencial

Mohino-Farré,

Martín-Callizo,

Just-Sarobé

2024

Piel

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Inflammatory bowel disease and immune-mediated inflammatory diseases: looking at the less frequent associations

Bezzio¹,

Corte²,

Vernero

et al. 2022

Therap Adv Gastroenterol

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Patients with inflammatory bowel disease (IBD) often have other immune-mediated inflammatory diseases (IMIDs), and the prevalence of any IMID is higher in IBD patients than in the general population. IBD and other IMIDs involve alterations in innate and adaptive immune responses. Their co-occurrence depends on shared immune and inflammatory processes, pathogenic mechanisms, and genetic and environmental risk factors, including drugs, especially tumor necrosis factor inhibitors. The more common IMIDs associated with IBD have been widely described, so this review focuses on the less frequent associations. The IMIDs discussed here are skin disorders (psoriasis, atopic dermatitis, vitiligo, epidermolysis bullosa acquisita, cutaneous polyarteritis nodosa, and hidradenitis suppurativa), hepato-pancreatic diseases (autoimmune hepatitis, granulomatous hepatitis, and autoimmune pancreatitis), endocrine diseases (autoimmune thyroid diseases, and type 1 diabetes mellitus), multiple sclerosis, and respiratory diseases (asthma, bronchiectasis, and interstitial pneumonia). The early detection of IMIDs in IBD patients is important to prevent their deleterious clinical course and limit their psychological impact. Care for IBD patients with IMIDs should be multispecialist, with a single therapeutic strategy instead of treating each disease separately.

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Abordaje terapéutico de la enfermedad de Crohn: posibles paralelismos con la hidradenitis supurativa

Cited by 3 publications

References 0 publications

Bergenin Alleviates Ulcerative Colitis By Decreasing Gut Commensal Bacteroides vulgatus-Mediated Elevated Branched-Chain Amino Acids

Bergenin Alleviates Ulcerative Colitis By Decreasing Gut Commensal Bacteroides vulgatus-Mediated Elevated Branched-Chain Amino Acids

Hidradenitis supurativa perianal o enfermedad de Crohn perianal: diagnóstico diferencial

Inflammatory bowel disease and immune-mediated inflammatory diseases: looking at the less frequent associations

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