Aboriginal bush foods: A major phloroglucinol from Crimson Bottlebrush flowers (Callistemon citrinus, Myrtaceae) displays strong antinociceptive and anti-inflammatory activity

Radulović, Niko S.; Randjelović, Pavle J.; Stojanović, Nikola; Cakić, Nevenka; Bogdanović, Goran A.; Zivanovic, Ana

doi:10.1016/j.foodres.2015.02.023

Cited by 35 publications

(31 citation statements)

References 46 publications

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“…Therefore, it can be used in multiple media to determine both hydrophilic and lipophilic antioxidant capacities of extracts and body fluids [35]. Generally, our findings agree with the existing evidence that phytochemicals in Callistemon extracts demonstrate strong in vitro antioxidant activity which can further be utilized to neutralize free radicals [42].…”

Section: Antioxidant Capacities Of Callistemon Extractssupporting

confidence: 89%

Bioactivities of phytochemicals in Callistemon citrinus against multi-resistant foodborne pathogens, alpha glucosidase inhibition and MCF-7 cancer cell line

Fayemi

Öztürk

Kaan

et al. 2019

Biotechnology & Biotechnological Equipment

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This study investigates in-vitro activities of phytochemicals in Callistemon citrinus against multiresistant foodborne pathogens, alpha-glucosidase enzyme and MCF-7 cancer cell line. Assays were prepared with lyophilized extracts to determine antioxidant capacity, inhibition of a-glucosidase enzyme and growth of foodborne bacteria. Annexin-V detection kit was used for apoptosis detection and FT-IR spectroscopy to confirm structural and functional groups of phytochemicals. Cytotoxicity of the extracts against MCF-7 cells was monitored with xCELLigence Real-Time Cell Analyser. The result from FT-IR analysis gave a peak at 3295 cm À1 wavenumber, confirming the presence of O-H alcohol functional group. FT-IR analysis also showed the presence of different functional groups such as carboxylic acids, aromatics, alkanes, alcohols, aliphatic amines, alkenes and amine groups in the extracts. Callistemon exhibited strong antioxidant capacities with EC 50 values of 0.474 ± 0.03 and 0.787 ± 0.15 mL sample/g of 2,2-diphenyl-1-picrylhydeazyl (DPPH) from leaf and flower extracts, respectively. Growth inhibition of most gram-positive foodborne bacteria by phytochemicals from flower extract appeared more promising as an alternative antimicrobial agent for food preservation. IC 50 value of 3.69 ± 0.61 lg/mL obtained from leaf extract showed its inhibitory potential against a-glucosidase enzyme for managing diabetes type-2. A dose response obtained from real-time monitoring with xCELLigence system indicated higher cytotoxicity of the extracts against MCF-7 cell line at !200 lg/mL concentrations within 24 h of incubation. The versatility of phytochemicals in Callistemon observed in this study signifies its potential for enhancing feed or food functionality, moderating blood glucose level and inhibiting the growth of foodborne pathogens or invasive carcinoma in man.

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Section: Antioxidant Capacities Of Callistemon Extractssupporting

confidence: 89%

Bioactivities of phytochemicals in Callistemon citrinus against multi-resistant foodborne pathogens, alpha glucosidase inhibition and MCF-7 cancer cell line

Fayemi

Öztürk

Kaan

et al. 2019

Biotechnology & Biotechnological Equipment

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“…The concentration of nitrites present in tissue homogenates was measured using a Griess reagent [ 20 ]. The mixture consisting of tissue homogenate and Griess reagent was incubated at room temperature for 10 min, and the absorbance of each sample was measured at 540 nm using a microplate reader.…”

Section: Methodsmentioning

confidence: 99%

The Encapsulation of Lycopene in Nanoliposomes Enhances Its Protective Potential in Methotrexate‐Induced Kidney Injury Model

Stojiljković

Ilić

Jakovljević

et al. 2018

Oxidative Medicine and Cellular Longevity

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Methotrexate is an antimetabolic drug with a myriad of serious side effects including nephrotoxicity, which presumably occurs due to oxidative tissue damage. Here, we evaluated the potential protective effect of lycopene, a potent antioxidant carotenoid, given in two different pharmaceutical forms in methotrexate-induced kidney damage in rats. Serum biochemical (urea and creatinine) and tissue oxidative damage markers and histopathological kidney changes were evaluated after systemic administration of both lycopene dissolved in corn oil and lycopene encapsulated in nanoliposomes. Similar to previous studies, single dose of methotrexate induced severe functional and morphological alterations of kidneys with cell desquamation, tubular vacuolation, and focal necrosis, which were followed by serum urea and creatinine increase and disturbances of tissue antioxidant status. Application of both forms of lycopene concomitantly with methotrexate ameliorated changes in serum urea and creatinine and oxidative damage markers and markedly reversed structural changes of kidney tissue. Moreover, animals that received lycopene in nanoliposome-encapsulated form showed higher degree of recovery than those treated with free lycopene form. The findings of this study indicate that treatment with nanoliposome-encapsulated lycopene comparing to lycopene in standard vehicle has an advantage as it more efficiently reduces methotrexate-induced kidney dysfunction.

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“…The concentration of nitrates/nitrites present in lung tissue homogenates was determined in a mixture consisting of tissue homogenate and Griess reagent (19). The amount of citrulline in lung tissue homogenate was determined according to the standard method that is based on the reaction with diacetyl monoxime and thiosemicarbazide (20).…”

Section: Determination Of Biochemical Parameters Related To Arginine mentioning

confidence: 99%

Melatonin treatment prevents carbon tetrachloride-induced acute lung injury in rats by mitigating tissue antioxidant capacity and inflammatory response

Radović¹,

Ristic²,

Krtinić³

et al. 2019

BLL

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AIM: Carbon tetrachloride (CCl 4) is an organic chemical that produces different tissue-damaging effects when ingested or inhaled. Present study aims to determine whether the application of exogenous melatonin, a neurohormone with numerous biological properties, can prevent disturbances in lung tissue antioxidative capacities and arginine metabolism, tissue infl ammation and oxidative damage induced by exposure to CCl 4 in rats. METHODS: The effects of melatonin on the changes occurring in rat lung tissue after an acute exposure to CCl 4 were studied by monitoring alterations in antioxidant capacities, infl ammatory parameters, parameters of arginine metabolism, and lipid and protein oxidative damage. RESULTS: The results indicated that melatonin prevents CCl 4-induced lung damage by mitigating tissue antioxidant capacity and preventing nitric oxide production through a shift from nitric oxide synthase to arginase. Also, melatonin partially prevented tissue infl ammation and molecules' oxidative modifi cation seen after exposure to CCl 4. CONCLUSIONS: The protective activity of melatonin can be attributed to its ability to scavenge both free radicals, as well as to its potential to increase tissue antioxidant capacity. The modulation of infl ammatory response through both decrease in tissue infl ammatory parameters and infl uence on arginine-nitric oxide metabolism might be an additional mechanism of action (Tab. 1, Fig. 2, Ref. 33).

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Aboriginal bush foods: A major phloroglucinol from Crimson Bottlebrush flowers (Callistemon citrinus, Myrtaceae) displays strong antinociceptive and anti-inflammatory activity

Cited by 35 publications

References 46 publications

Bioactivities of phytochemicals in Callistemon citrinus against multi-resistant foodborne pathogens, alpha glucosidase inhibition and MCF-7 cancer cell line

Bioactivities of phytochemicals in Callistemon citrinus against multi-resistant foodborne pathogens, alpha glucosidase inhibition and MCF-7 cancer cell line

The Encapsulation of Lycopene in Nanoliposomes Enhances Its Protective Potential in Methotrexate‐Induced Kidney Injury Model

Melatonin treatment prevents carbon tetrachloride-induced acute lung injury in rats by mitigating tissue antioxidant capacity and inflammatory response

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