Abortions in sheep caused by<i>Salmonella</i>Brandenburg: Pathological findings

Clark, R.G.; Gill, JM; Fairley, R A; Smart, J. O.

doi:10.1080/00480169.2007.36794

Cited by 6 publications

(2 citation statements)

References 1 publication

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“…Some of the serotypes isolated during this survey have been responsible for several human salmonellosis outbreaks worldwide. In New Zealand, salmonellosis caused by S. Brandenburg is considered an emerging zoonosis (Baker et al., 2006) and outbreaks have been associated with cattle and sheep infection (Clark et al., 2007). The serotype Brandenburg can potentially cause bacteraemia and severe focal extra‐intestinal infections (Rodriguez et al., 1998; Bjorkman et al., 2002).…”

Section: Discussionmentioning

confidence: 99%

SalmonellaInfection in Illegally Imported Spur‐Thighed Tortoises (Testudo graeca)

Percipalle

Giardina²,

Lipari

et al. 2011

Zoonoses and Public Health

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The prevalence of Salmonella infection was determined in a group of spur-thighed tortoises (Testudo graeca) seized during two smuggling attempts and in a population of captive Hermann's tortoises (Testudo hermanni) sheltered in a wildlife rescue centre. Salmonella spp. was isolated in 81 of 220 (36.8%) and in 17 of 67 (25.4%) cloacal swabs collected from the T. graeca and T. hermanni tortoises respectively. Overall, a total of 21 different Salmonella serotypes were found. Some of these serotypes are common to terrestrial chelonians while others have never been reported. All cultured serotypes were non-typhoidal but nonetheless many of these have been previously reported as source of human outbreaks of reptile-related salmonellosis. Eighty-two per cent and 5.3% of the isolates were resistant to two and three anti-microbial agents respectively. However, the isolates were highly susceptible to the anti-microbials of choice for the treatment of salmonellosis such as cephalosporins and fluoroquinolones. Our findings confirm that tortoises can be considered a reservoir for Salmonella and that care should be employed when handling and breeding these animals. Tight surveillance should be enforced to avoid illegal importation and prevent the trading of live tortoises, carriers of zoonotic pathogens.

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Section: Discussionmentioning

confidence: 99%

SalmonellaInfection in Illegally Imported Spur‐Thighed Tortoises (Testudo graeca)

Percipalle

Giardina²,

Lipari

et al. 2011

Zoonoses and Public Health

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show abstract

“…In recent year, multidrug resistance (MDR) strains were identified in Pakistan (2005) and India (2007) [2]. Salmonella causes abortion in mink [3] ewes [4], cattles [5] and horse [6] which also include some recent outbreaks [7], [8], [9].…”

Section: Introductionmentioning

confidence: 99%

A Safe Vaccine (DV-STM-07) against Salmonella Infection Prevents Abortion and Confers Protective Immunity to the Pregnant and New Born Mice

2010

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Pregnancy is a transient immuno-compromised condition which has evolved to avoid the immune rejection of the fetus by the maternal immune system. The altered immune response of the pregnant female leads to increased susceptibility to invading pathogens, resulting in abortion and congenital defects of the fetus and a subnormal response to vaccination. Active vaccination during pregnancy may lead to abortion induced by heightened cell mediated immune response. In this study, we have administered the highly attenuated vaccine strain ΔpmrG-HM-D (DV-STM-07) in female mice before the onset of pregnancy and followed the immune reaction against challenge with virulent S. Typhimurium in pregnant mice. Here we demonstrate that DV-STM-07 vaccine gives protection against Salmonella in pregnant mice and also prevents Salmonella induced abortion. This protection is conferred by directing the immune response towards Th2 activation and Th1 suppression. The low Th1 response prevents abortion. The use of live attenuated vaccine just before pregnancy carries the risk of transmission to the fetus. We have shown that this vaccine is safe as the vaccine strain is quickly eliminated from the mother and is not transmitted to the fetus. This vaccine also confers immunity to the new born mice of vaccinated mothers. Since there is no evidence of the vaccine candidate reaching the new born mice, we hypothesize that it may be due to trans-colostral transfer of protective anti-Salmonella antibodies. These results suggest that our vaccine DV-STM-07 can be very useful in preventing abortion in the pregnant individuals and confer immunity to the new born. Since there are no such vaccine candidates which can be given to the new born and to the pregnant women, this vaccine holds a very bright future to combat Salmonella induced pregnancy loss.

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Theriogenology of sheep, goats, and cervids

Edmondson¹,

Shipley²

2021

Sheep, Goat, and Cervid Medicine

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Abortions in sheep caused bySalmonellaBrandenburg: Pathological findings

Cited by 6 publications

References 1 publication

SalmonellaInfection in Illegally Imported Spur‐Thighed Tortoises (Testudo graeca)

SalmonellaInfection in Illegally Imported Spur‐Thighed Tortoises (Testudo graeca)

A Safe Vaccine (DV-STM-07) against Salmonella Infection Prevents Abortion and Confers Protective Immunity to the Pregnant and New Born Mice

Theriogenology of sheep, goats, and cervids

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