About a case of lymphoepithelioma-like carcinoma of the bladder

Chaker, Kays; Sellami, Ahmed; Ouanes, Yassine; Jallouli, W.; Chehida, Mohamed Ali Ben; Abid, Karem; Rhouma, Sami Ben; Nouira, Yassine

doi:10.1016/j.eucr.2018.03.002

Cited by 6 publications

(9 citation statements)

References 5 publications

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“…Macroscopic hematuria is the most common symptom and has been reported in the majority of cases. The stage at diagnosis of those tumors was in 87% of cases T2–T3 stage [ 3 ].…”

Section: Discussionmentioning

confidence: 99%

“…To date, the exact pathogenesis of this tumor is not well established. Although the association between lymphoepithelioma of the nasopharynx and other tissues (lung, stomach, thymus and salivary gland) and Epstein–Barr virus has already been proven, in the bladder, hybridization with Epstein–Barr virus-encoded RNA has been reported to be consistently negative in different series [ 3 ].…”

Section: Discussionmentioning

confidence: 99%

“…Some authors have suggested that abnormalities in p53 regulation have a role in the pathogenesis of these tumors [ 2 , 3 ]. Other authors have suggested a link between Bacillus Calmette-Guerin (BCG) therapy and LELC of the urinary bladder [ 3 ].…”

Section: Discussionmentioning

confidence: 99%

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Bladder lymphoepithelioma-like carcinoma: a case report

Rahoui

2022

Journal of Surgical Case Reports

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Bladder lymphoepithelioma-like carcinoma is a rare entity. It represents a particular variant of urothelial carcinoma characterized by an important infiltrating power. Therapeutic management of this cancer is not codified. Surgery associated with chemotherapy seems to be the best therapeutic option. Few cases of this tumor have been reported in the literature. We report a case of bladder lymphoepithelioma-like carcinoma in a 52-year-old patient who presented with gross hematuria and discusses difficulties of diagnostic and treatment.

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“…Macroscopic hematuria is the most common symptom and has been reported in the majority of cases. The stage at diagnosis of those tumors was in 87% of cases T2–T3 stage [ 3 ].…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Bladder lymphoepithelioma-like carcinoma: a case report

Rahoui

2022

Journal of Surgical Case Reports

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“…We believe, this short report may contribute to the literature.IntroductionBladder cancer is seventh commonly diagnosed cancer in men, and when both genders are considered, its ranking drops to eleventh [1] . More than %90 cases are urothelial carcinoma and the rest of them are the variant histology that was described in 2016 WHO classification of tumours based on 2004 classification [2]. Lymphoepithelioma-like carcinoma of the bladder (LELC-B) is a rare variant and was first described in 1991 with five cases that were mimicking lymphoma [3].…”

Section: Introductionmentioning

confidence: 99%

Programmed Death Cell Ligand-1 Expression in Lymphoepithelioma-like Carcinoma of the Bladder: A Case Report

Teoman,

Kucuk,

Teoman

2024

Preprint

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Introduction: Lymphoepithelioma-like carcinoma of the bladder (LELC-B) is a rare variant of bladder tumors and until today only 145 cases are reported in the literature. It has a worse prognosis and survival rates in comparison with papillary muscle invasive tumors. However, general treatment options including radical cystectomy, chemotherapy and radiotherapy; discovery of the programmed death cell ligand-1 (PDL-1) expression for LELC-B recently, may lead a novel immunohistochemical diagnostic method and PDL-1 immunostaining may increase detection of this variant. Case Presentation: A 72-year-old male patient with lower urinary tract symptoms is diagnosed as bladder tumor with imaging modalities. After transurethral resection of this bladder tumor, immunopathological diagnose was muscle invasive bladder tumor predominantly lymphepithelioma like carcinoma of the bladder. PDL-1 immunostaining was also highly positive(>%50). Discussion/Conclusion: Lymphoepithelioma-like cancer of bladder is an undifferantiated aggressive rare variant of bladder cancers. Its identifiability may increase with detection of PDL-1 expression. In the future, that might pave a road to targeted immunotherapies as an alternative for selected patients.

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“…Lymphoepithelioma-like carcinoma (LELC) is a rare variant of infiltrating urothelial carcinoma first described in the bladder by Zukerberg et al in 1991 [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Lymphoepithelioma-Like Carcinoma of the Bladder: A Case Report of a Rare and Particular Variant of Urothelial Carcinoma

Jabbour

Jabri

Lamchahab

et al. 2018

Case Reports in Urology

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Lymphoepithelioma-like carcinoma of the bladder (LELCB) is a rare variant of urothelial carcinoma first described by Zukerberg in 1991 and confirmed as a variant of urothelial carcinoma by the WHO classification of tumors of the urinary system. LELCB is characterized by a marked infiltration of lymphocytes in the area involved by the tumor which may coexist with the conventional urothelial carcinoma. LELCB are classified according to the percentage of lymphoepithelioma component within the tumor with the prognosis depending on the percentage. We report a new case of pure LELCB occurring in 63-year-old woman presenting with hematuria. Ultrasonography and cystoscopy revealed a large tumor on the left lateral wall of the bladder. Transurethral resection of the bladder tumor (TURBT) was performed. Pathological and immunohistochemical analysis revealed a high-grade muscle-invasive LELCB (G3pT2). The patient underwent an adjuvant systemic chemotherapy with no recurrence after a ten-month follow-up. To our knowledge, this is the second Moroccan case of LELCB reported in the English literature. Although its rare occurrence prognosis and ideal therapeutic management of LELCB have not been clearly established yet, literature findings encourage the adoption of a conservative approach in treatment of LELCB.

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About a case of lymphoepithelioma-like carcinoma of the bladder

Cited by 6 publications

References 5 publications

Bladder lymphoepithelioma-like carcinoma: a case report

Bladder lymphoepithelioma-like carcinoma: a case report

Programmed Death Cell Ligand-1 Expression in Lymphoepithelioma-like Carcinoma of the Bladder: A Case Report

Lymphoepithelioma-Like Carcinoma of the Bladder: A Case Report of a Rare and Particular Variant of Urothelial Carcinoma

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