About mechanism of chitosan cross-linking with glutaraldehyde

Chitosan nanoparticle based delivery systems for sustainable agriculture

“…Release of active ingredient depends on molecular weight, degree of deacetylation, and concentration of chitosan [66,[158][159][160][161][162] Emulsion cross-linking High drug loading efficiency; controlled release with improved bioavailability; and easy to control particle size Tedious process, uses harsh crosslinking agents, problem of reactivity of active agent with cross-linking agent, and challenge of complete removal of unreacted cross-linking agent [40,66,159,161,163] Emulsion-droplet coalescence High loading efficiency and smaller particle size Particle size depends on the degree of deacetylation of chitosan. The decreased degree of deacetylation increases particle size which in turn decreases drug content [66,164] Precipitation Efficient control of particle size and drug release; and avoids the use of toxic organic solvents Partial protection of the loaded active agent from nuclease degradation [40,159] Reverse micellar method Thermodynamically stable particle size with suitable polydispersity index; and narrow size distribution with smaller particle size…”

Effect of the degree of cross-linking of N-2-sulfoethylchitosan on the sorption selectivity of copper(II) and silver(I)

“…Despite that glutaric aldehyde is present in aqueous solutions not only as the monomer form, but also as selfcondensation products [23,24], it is possible to evaluate the conditional degree of cross-linking by using the DCF, the molar fraction of amino groups that have reacted with the cross-linking agent [17]. As follows from the data in Table 1, raising the amount of glutaric aldehyde results in an increase in DCF.…”

Electrospinning of Cross-Linked Magnetic Chitosan Nanofibers for Protein Release

“…The cross-linking reaction of chitosan in acetic acid proceeds with a high rate (36,37). In the case of GA, a Bdouble-crosslinking^method was utilized to synthesize Fe 3 O 4 /GA.…”