About the controversies of the cardioprotective effect of n-3 polyunsaturated fatty acids (PUFAs) between animal studies and clinical meta-analyses: a review with several strategies to enhance the beneficial effects of n-3 PUFAs

Demaison, Luc; Leger, Thibault; Vergely, Catherine; Rochette, Luc; Azarnoush, Kasra

doi:10.1007/s13105-019-00670-y

Cited by 2 publications

(2 citation statements)

References 62 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As electrophysiological experiments did not reveal any abnormalities related to high ischemic and reperfusion arrhythmogenesis in SHR-CRP, we focused on biochemical analyses of selected myocardial and plasma lipids that could be responsible for the proarrhythmic phenotype. In experimental animal models, a long-lasting intake of food enriched with n-3 PUFAs decreases the myocardial phospholipid n-6/n-3 PUFA ratio and diminishes the incidence and severity of ventricular arrhythmias during I/R [40][41][42][43]. In patients, higher consumption of n-3 PUFAs reduces the incidence of coronary heart disease and sudden cardiac death [44,45]; the inverse relationship between plasma CRP and n-3 PUFAs levels was reported [46][47][48].…”

Section: Proarrhythmic Phenotype In Shr-crpmentioning

confidence: 99%

Excess ischemic tachyarrhythmias trigger protection against myocardial infarction in hypertensive rats

et al. 2021

View full text Add to dashboard Cite

Increased level of C-reactive protein (CRP) is a risk factor for cardiovascular diseases, including myocardial infarction and hypertension. Here, we analyze the effects of CRP overexpression on cardiac susceptibility to ischemia/reperfusion (I/R) injury in adult spontaneously hypertensive rats (SHR) expressing human CRP transgene (SHR-CRP). Using an in vivo model of coronary artery occlusion, we found that transgenic expression of CRP predisposed SHR-CRP to repeated and prolonged ventricular tachyarrhythmias. Excessive ischemic arrhythmias in SHR-CRP led to a significant reduction of infarct size (IS) compared with SHR. The proarrhythmic phenotype in SHR-CRP was associated with altered heart and plasma eicosanoids, myocardial composition of fatty acids in phospholipids, and autonomic nervous system imbalance before ischemia. To explain unexpected IS-limiting effect in SHR-CRP, we performed metabolomic analysis of plasma before and after ischemia. We also determined cardiac ischemic tolerance in hearts subjected to remote ischemic perconditioning (RIPer) and in hearts ex vivo. Acute ischemia in SHR-CRP markedly increased plasma levels of multiple potent cardioprotective molecules that could reduce IS at reperfusion. RIPer provided IS-limiting effect in SHR that was comparable with myocardial infarction observed in naïve SHR-CRP. In hearts ex vivo, IS did not differ between the strains, suggesting that extra-cardiac factors play a crucial role in protection. Our study shows that transgenic expression of human CRP predisposes SHR-CRP to excess ischemic ventricular tachyarrhythmias associated with a drop of pump function that triggers myocardial salvage against lethal I/R injury likely mediated by protective substances released to blood from hypoxic organs and tissue at reperfusion.

show abstract

Section: Proarrhythmic Phenotype In Shr-crpmentioning

confidence: 99%

Excess ischemic tachyarrhythmias trigger protection against myocardial infarction in hypertensive rats

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Inflammation-mediated specialized pro-resolving lipid mediators can be derived from arachidonic acid or omega-3 FA, and these can be released from the membrane in ischemia. Therefore, administration of omega-3 FA in acute myocardial infarction, ischemia and reperfusion [242] or sympathetic overdrive can be harmful, and even pro-arrhythmic [243]. Omega-3 FA alters cardiac electrophysiology and may be pro-or antiarrhythmic, depending on the arrhythmia mechanism, and acute interaction of the beta-adrenergic overdrive can be responsible for either survival or sudden death [226].…”

Section: Antiarrhythmic Efficacy Of Omega-3 Fatty Acidsmentioning

confidence: 99%

Mechanisms Underlying Antiarrhythmic Properties of Cardioprotective Agents Impacting Inflammation and Oxidative Stress

Andelová

Bacova

Sýkora

et al. 2022

IJMS

View full text Add to dashboard Cite

The prevention of cardiac life-threatening ventricular fibrillation and stroke-provoking atrial fibrillation remains a serious global clinical issue, with ongoing need for novel approaches. Numerous experimental and clinical studies suggest that oxidative stress and inflammation are deleterious to cardiovascular health, and can increase heart susceptibility to arrhythmias. It is quite interesting, however, that various cardio-protective compounds with antiarrhythmic properties are potent anti-oxidative and anti-inflammatory agents. These most likely target the pro-arrhythmia primary mechanisms. This review and literature-based analysis presents a realistic view of antiarrhythmic efficacy and the molecular mechanisms of current pharmaceuticals in clinical use. These include the sodium‑glucose cotransporter-2 inhibitors used in diabetes treatment, statins in dyslipidemia and naturally protective omega-3 fatty acids. This approach supports the hypothesis that prevention or attenuation of oxidative and inflammatory stress can abolish pro-arrhythmic factors and the development of an arrhythmia substrate. This could prove a powerful tool of reducing cardiac arrhythmia burden.

show abstract

About the controversies of the cardioprotective effect of n-3 polyunsaturated fatty acids (PUFAs) between animal studies and clinical meta-analyses: a review with several strategies to enhance the beneficial effects of n-3 PUFAs

Cited by 2 publications

References 62 publications

Excess ischemic tachyarrhythmias trigger protection against myocardial infarction in hypertensive rats

Excess ischemic tachyarrhythmias trigger protection against myocardial infarction in hypertensive rats

Mechanisms Underlying Antiarrhythmic Properties of Cardioprotective Agents Impacting Inflammation and Oxidative Stress

Contact Info

Product

Resources

About