About the effect of eye blinking on drug release from pHEMA-based hydrogels: an<i>in vitro</i>study

Galante, Raquel; Paradiso, Patrizia; Moutinho, Maria Guilhermina; Fernandes, Ana I.; Mata, José L.; Matos, A. P. Alves de; Colaço, R.; Saramago, Benilde; Serro, Ana Paula

doi:10.1080/09205063.2014.994948

Cited by 26 publications

(12 citation statements)

References 51 publications

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“…In a previous work performed by Serro et al, the authors concluded that friction does not influence significantly the LVF release of thermal polymerized HEMA/PVP hydrogels, which is confirmed by the data presented here.…”

Section: Resultssupporting

confidence: 90%

Drug release from liposome coated hydrogels for soft contact lenses: the blinking and temperature effect

Paradiso

Colaço

Mata

et al. 2016

J. Biomed. Mater. Res.

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In this article, liposome-based coatings aiming to control drug release from therapeutic soft contact lenses (SCLs) materials are analyzed. A PHEMA based hydrogel material loaded with levofloxacin is used as model system for this research. The coatings are formed by polyelectrolyte layers containing liposomes of 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) and DMPC + cholesterol (DMPC + CHOL). The effect of friction and temperature on the drug release is investigated. The aim of the friction tests is to simulate the blinking of the eyelid in order to verify if the SCLs materials coated with liposomes are able to keep their properties, in particular the drug release ability. It was observed that under the study conditions, friction did not affect significantly the drug release from the liposome coated PHEMA material. In contrast, increasing the temperature of release leads to an increase of the drug diffusion rate through the hydrogel. This phenomenon is recorded both in the control and in the coated samples. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 1799-1807, 2017.

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Section: Resultssupporting

confidence: 90%

Drug release from liposome coated hydrogels for soft contact lenses: the blinking and temperature effect

Paradiso

Colaço

Mata

et al. 2016

J. Biomed. Mater. Res.

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“…This observation also has been reported in another study modelling the effects of blinking on drug release from hydrogels. 24 Furthermore, the tear film is shear-thinning (non-Newtonian) in which the viscosity is not constant. We speculate that the rubbing process between the eyelid and corneal eyepiece decreases the viscosity of the ATS, 33,39 which increases the amount of drugs released from the CL.…”

Section: Discussionmentioning

confidence: 99%

“…23 The effects of eye blinking on drug release from hydrogels has been noted in only one study. 24 To our knowledge, no studies have examined the combined effects of an artificial tear solution (ATS) that mimics the composition of the human tear film and mechanical wear on drug release from CLs. The aim of this study was to evaluate and compare the release of moxifloxacin from a variety of daily disposable (DD) CLs in an ATS when exposed to mechanical rubbing using a novel in vitro eye model.…”

Section: Introductionmentioning

confidence: 99%

Release of Moxifloxacin from Contact Lenses Using an In Vitro Eye Model: Impact of Artificial Tear Fluid Composition and Mechanical Rubbing

Phan

Bajgrowicz-Cieslak

Subbaraman

et al. 2016

Trans. Vis. Sci. Tech.

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PurposeThe aim of this study was to evaluate and compare the release of moxifloxacin from a variety of daily disposable (DD) contact lenses (CLs) under various conditions using a novel in vitro eye model.MethodsFour commercially available DD conventional hydrogel (CH) CLs (nelfilcon A, omafilcon A, etafilcon A, and ocufilcon B) and three silicone hydrogel (SH) CLs (somofilcon A, narafilcon A, and delefilcon A) were evaluated. These lenses were incubated in moxifloxacin for 24 hours. The release of the drug was measured using a novel in vitro model in three experimental conditions: (1) phosphate buffered saline (PBS); (2) artificial tear solution (ATS) containing a variety of proteins and lipids; and (3) ATS with mechanical rubbing produced by the device.ResultsOverall, CH CLs had a higher drug release than SH CLs (P < 0.05) under all conditions. Typically, a higher drug release was observed in PBS than ATS (P < 0.05). For CH, drug release was found to be higher in ATS with rubbing than PBS or ATS (P < 0.05). For most lens types, ATS with rubbing produced higher drug release than ATS alone (P < 0.05). Generally, the release kinetics for all conditions were sustained over the 24-hour testing period, and no burst release was observed (P < 0.05).ConclusionsMoxifloxacin release from a CL into ATS is lower when compared to release into PBS. When mechanical rubbing is introduced, the amount of drugs released is increased.Translational RelevanceResults suggest that sophisticated in vitro models are necessary to adequately model on-eye drug release from CL materials.

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“…The predicted drug concentrations were estimated from the theoretical fractional mass release profiles based on a mathematical model described in Paradiso el al. [5]. Here, the thickness of the inner loaded lens was maintained at 0.5 mm, and the drug diffusivity in that material was maintained at 7.5x10 -13 m 2 s -1 .…”

Section: Resultsmentioning

confidence: 99%

“…The main drawbacks that remain to be solved include the initial burst of drug release and the limited duration of active release after the placement of the lens in the eye. The simplest approach for preparing drug-loaded OLs, which has been the focus of many previous studies, involves soaking hydrophilic lenses in commercial drug solutions [2,5,6]. This minimalistic approach, although leading to more effective drug release control and drug absorption than eye drops, in general, cannot provide extended drug release [7,8].…”

Section: Introductionmentioning

confidence: 99%

Diffusion-Based Design of Multi-Layered Ophthalmic Lenses for Controlled Drug Release

et al. 2016

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The study of ocular drug delivery systems has been one of the most covered topics in drug delivery research. One potential drug carrier solution is the use of materials that are already commercially available in ophthalmic lenses for the correction of refractive errors. In this study, we present a diffusion-based mathematical model in which the parameters can be adjusted based on experimental results obtained under controlled conditions. The model allows for the design of multi-layered therapeutic ophthalmic lenses for controlled drug delivery. We show that the proper combination of materials with adequate drug diffusion coefficients, thicknesses and interfacial transport characteristics allows for the control of the delivery of drugs from multi-layered ophthalmic lenses, such that drug bursts can be minimized, and the release time can be maximized. As far as we know, this combination of a mathematical modelling approach with experimental validation of non-constant activity source lamellar structures, made of layers of different materials, accounting for the interface resistance to the drug diffusion, is a novel approach to the design of drug loaded multi-layered contact lenses.

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About the effect of eye blinking on drug release from pHEMA-based hydrogels: anin vitrostudy

Cited by 26 publications

References 51 publications

Drug release from liposome coated hydrogels for soft contact lenses: the blinking and temperature effect

Drug release from liposome coated hydrogels for soft contact lenses: the blinking and temperature effect

Release of Moxifloxacin from Contact Lenses Using an In Vitro Eye Model: Impact of Artificial Tear Fluid Composition and Mechanical Rubbing

Diffusion-Based Design of Multi-Layered Ophthalmic Lenses for Controlled Drug Release

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