About the unresolved problems of terminology and classification of allergic rhinitis and the desirability of distinguishing the mixed form of the disease

Gadzhimirzaev, G A

doi:10.17116/otorino201681534-36

Cited by 1 publication

(1 citation statement)

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“…The GO and KEGG enrichment analyses supported the former and identified molecular signaling pathways in the pathophysiology of AR. For example, the inflammation pathways, such as the cGMP-PKG signaling pathway (Zhang X. et al, 2022) and AMPK signaling pathway (Zhang et al, 2022a), coagulation cascade (Hong et al, 2018), lipid, carbohydrate, and amino acid metabolic pathways (Gadzhimirzaev et al, 2011;Sun et al, 2021), transcription and translation processes, were reported to contribute to the initiation and exacerbation of AR. A total of 14 hub proteins, elongation factor 2 (EEF2), Ras-related protein Rab-10 (RAB10), Ras-related protein Rab-11B (RAB11B), S-adenosylmethionine synthase isoform type-2 (MAT2A), high-affinity immunoglobulin epsilon receptor subunit gamma (FCER1G), integrin alpha-2 (ITGA2), pleckstrin (PLEK), thrombospondin-1, (THBS1), histone cluster 1 h2b family member k (HIST1H2BK), gelsolin (GSN), caldesmon 1 (CALD1), rhoassociated protein kinase 2 (ROCK2), myosin heavy chain 9/10/11/14 (MYH9), and alcohol dehydrogenase [NADP(+)] (AKR1A1), may play a pivotal role in the pathology of AR.…”

Section: Discussionmentioning

confidence: 99%

HMGN2 and Histone H1.2: potential targets of a novel probiotic mixture for seasonal allergic rhinitis

Li,

Wen,

Gong

et al. 2023

Front. Microbiol.

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BackgroundAllergic rhinitis (AR) is a common nasal inflammatory disorder that severely affects an individual's quality of life (QoL) and poses a heavy financial burden. In addition to routine treatments, probiotic intervention has emerged as a promising strategy for preventing and alleviating allergic diseases. The main objective of this study was to determine the effect of a novel multi-strain probiotic mixture on AR symptoms and investigate potential targets underlying the probiotic intervention.MethodsA randomized, double-blind, placebo-controlled clinical study was conducted on AR patients who were allergic to autumnal pollens (n = 31). Placebo or a novel probiotic mixture, composed of Lactobacillus rhamnosus (L. rhamnosus) HN001, L. acidophilus NCFM, Bifidobacterium lactis (B. lactis) Bi-07, L. paracasei LPC-37, and L. reuteri LE16, was administered after 2 months. The therapeutic efficacy was evaluated by a symptom assessment scale. Before and during the pollen season, blood samples were collected, and peripheral blood mononuclear cells (PBMCs) were isolated for further tandem mass tags (TMTs)-based quantitative proteomic analyses. Potential targets and underlying pathological pathways were explored using bioinformatics methods.ResultsDuring the pollen season, the rhinoconjunctivitis symptom score of participants who were administered probiotics (probiotic group, n = 15) was significantly lower than those administered placebo (placebo group, n = 15) (P = 0.037). The proteomic analyses identified 60 differentially expressed proteins (DEPs) in the placebo group, and subsequent enrichment analyses enriched a series of pathways and biological processes, including signaling pathways of inflammation, coagulation cascade, lipid, carbohydrate and amino acid metabolic pathways, and transcription and translation processes. Least Absolute Shrinkage and Selection Operator (LASSO) regression extracted five main elements, namely, GSTO1, ATP2A2, MCM7, PROS1, and TRIM58, as signature proteins. A total of 17 DEPs were identified in the probiotic group, and there was no pathway enriched. Comparison of DEPs in the two groups revealed that the expression levels of the high-mobility group nucleosome-binding domain-containing protein 2 (HMGN2) and Histone H1.2 presented an opposite trend with different interventions.ConclusionOur data showed that AR symptoms alleviated after treatment with the novel multi-strain probiotic mixture, and the proteomic analyses suggested that HMGN2 and Histone H1.2 might be targets of probiotic intervention for seasonal AR.

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