ABrugia malayiAntigen Specifically Recognized by Infected Individuals

Rahmah, N.; Anuar, A. Khairul; A'shikin, A.Noor; Lim, Boon Huat; Mehdi, R.; Abdullah, Basima A.; Nor, Zurainee Mohamed

doi:10.1006/bbrc.1998.9360

Cited by 4 publications

(1 citation statement)

References 9 publications

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“…We hypothesized that liraglutide treatment could enhance lipolysis and upregulate the AC3-cAMP-PKA-HSL pathway. Phosphorylation of HSL at Ser660 is critical for activation of the protein’s intrinsic enzymatic activity 33. Therefore, we compared the protein expression levels of hepaticAC3, HSL and p-HSL(S660), and the mRNA expression levels of AC3 and HSL, and cAMP levels and PKA activity in livers of obese and normal control mice with and without liraglutide treatment.…”

Section: Discussionmentioning

confidence: 99%

<p>Effects of liraglutide on lipolysis and the AC3/PKA/HSL pathway</p>

Yang

Liang

et al. 2019

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Background Liraglutide reduces blood glucose, body weight and blood lipid levels. Hormone-sensitive lipase (HSL) is a key enzyme in lipolysis. Evidence from our and other studies have demonstrated that adenylate cyclase 3 (AC3) is associated with obesity and can be upregulated by liraglutide in obese mice. In the present study, we investigated whether hepatic HSL activity is regulated by liraglutide and characterized the effect of liraglutide in the AC3/protein kinase A (PKA)/HSL signalling pathway. Methods Obese mice or their lean littermates were treated with liraglutide or saline for 8 weeks. Serum was collected for the measurement of insulin and lipids. We investigated hepatic AC3, HSL and phosphorylated HSL Ser-660 (p-HSL(S660)) protein expression levels andAC3 and HSL mRNA expression levels and cyclic adenosine monophosphate (cAMP), PKA activity in liver tissue. Results Liraglutide treatment decreased triglycerides (TGs) and free fatty acids (FFAs), increased glycerol, and upregulated hepatic AC3 and p-HSL(s660) levels and cAMP and PKA activities. Conclusion The results suggest that liraglutide can upregulates AC3/PKA/HSL pathway and may promotes lipolysis.

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Section: Discussionmentioning

confidence: 99%

<p>Effects of liraglutide on lipolysis and the AC3/PKA/HSL pathway</p>

Yang

Liang

et al. 2019

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Ätiologie sekundärer Lymphödeme nicht onkologischer Genese

Neuhüttler¹,

Kröll²,

Brenner³

2006

Phlebologie

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Zusammenfassung60% aller Lymphödeme entfallen auf sekundäre Lymphödeme, unter diesen liefern Neoplasien für über die Hälfte die Ursache; ein immer noch beträchtlicher Anteil entfällt damit auf sekundäre Lymphödeme nicht onkologischer Genese. Mit dieser Arbeit wird versucht, einen Überblick über die verschiedenen, in der Literatur erwähnten, Ätiologien dieses Formenkreises zu geben. Prinzipiell kann hier eine Gliederung in zwei Gruppen erfolgen: 1. Ursachen mit immunologischer Aktivität (z. B. Helminthen, Bakterien, Spirochäten, Viren, Pilze, allergische Kontaktdermatitis, Phlebitis, Rheumatoide Arthritis, Morbus Crohn); 2. Ursachen ohne immunologische Aktivität (z. B. Traumata, iatrogene Schäden, Pharmaka, Podokoniose). Hier wird einmal mehr ersichtlich, dass die Erkrankung Lymphödem aufgrund der großen Vielfalt der Ätiologien nicht einer einzelnen klinischen Disziplin untergeordnet werden kann, sondern vielmehr fächerübergreifend gesehen werden muss.

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The control of the human filariases

Michael¹

1999

Current Opinion in Infectious Diseases

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ABrugia malayiAntigen Specifically Recognized by Infected Individuals

Cited by 4 publications

References 9 publications

<p>Effects of liraglutide on lipolysis and the AC3/PKA/HSL pathway</p>

<p>Effects of liraglutide on lipolysis and the AC3/PKA/HSL pathway</p>

Ätiologie sekundärer Lymphödeme nicht onkologischer Genese

The control of the human filariases

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