Abrupt rather than gradual hormonal changes induce postpartum blues-like behavior in rats

Doornbos, Bennard; Fokkema, Dirk S.; Molhoek, Margo; Tanke, Marit A.C.; Postema, Folkert; Korf, Jakob

doi:10.1016/j.lfs.2008.10.014

Cited by 32 publications

(16 citation statements)

References 35 publications

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“…Interestingly, the rate at which 14 progesterone declines appears to be an important determinant of the drug withdrawal effect. In a rat model, adverse behavioral changes were precipitated only following a rapid withdrawal from long term dosing with progesterone, but did not occur if progesterone declined slowly (Doornbos et al, 2009). The latter scenario is analogous to the asymptomatic participants in the present study who experienced a gradual decline in progesterone during the mid and late luteal phase and who did not develop premenstrual symptoms.…”

Section: Discussionsupporting

confidence: 57%

A specific profile of luteal phase progesterone is associated with the development of premenstrual symptoms

Lovick

Guapo

Anselmo-Franci

et al. 2017

Psychoneuroendocrinology

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Lovick, T., Guapo, V. G., Amselmo-Franci, J. A., Loureiro, C. M., Faleiros, C. M., Del Ben, C. M., & Brandão, M. L. (2017). A specific profile of luteal phase progesterone is associated with the development of premenstrual symptoms. Psychoneuroendocrinology, 75,[86][87][88][89][90] University of Bristol -Explore Bristol Research General rightsThis document is made available in accordance with publisher policies. Please cite only the published version using the reference above. Full terms of use are available: http://www.bristol.ac.uk/pure/about/ebr-terms There is a consensus that the development of premenstrual dysphoric states is related to cyclical change in gonadal hormone secretion during the menstrual cycle.However, results from studies seeking to link symptom severity to luteal phase progesterone concentration have been equivocal. In the present study we evaluated not only the absolute concentrations of progesterone but also the kinetics of the change in progesterone concentration in relation to development of premenstrual symptoms during the last 10 days of the luteal phase in a population of 46 healthy young adult Brazilian women aged 18-39 years, mean 26.5±6.7 years. In participants who developed symptoms of premenstrual distress, daily saliva progesterone concentration remained stable during most of the mid-late luteal phase, before declining sharply during the last 3 days prior to onset of menstruation. In contrast, progesterone concentration in asymptomatic women underwent a gradual decline over the last 8 days prior to menstruation. Neither maximum nor minimum concentrations of progesterone in the two groups were related to the appearance or severity of premenstrual symptoms. We propose that individual differences in the kinetics of progesterone secretion and/or metabolism may confer differential susceptibility to the development of premenstrual syndrome.

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Section: Discussionsupporting

confidence: 57%

A specific profile of luteal phase progesterone is associated with the development of premenstrual symptoms

Lovick

Guapo

Anselmo-Franci

et al. 2017

Psychoneuroendocrinology

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“…Interestingly, the critical event for inducing this effect may be related to the kinetics of the decline in steroid levels rather than the absolute magnitude of the fall. In a study on female rats chronically treated with estrogen and progesterone, a rapid withdrawal of these hormones precipitated increased startle and anxiety-like behaviour, which was not seen if the hormone levels were allowed to decline gradually (34,35). Since similar increases in anxiety behaviour can be precipitated by abrupt withdrawal from progesterone alone (16-18), the trigger for anxiogenesis in the former study is likely to be the rapid decline in concentration in the brain of progesterone, and hence its neuroactive metabolite ALLO.…”

Section: The Kinetics Of Progesterone Withdrawal Determines Its Anxiomentioning

confidence: 99%

Estrous cycle and stress: influence of progesterone on the female brain

Lovick

2012

Braz J Med Biol Res

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The female brain operates in a constantly changing chemical milieu caused by cyclical changes in gonadal hormones during the estrous cycle (menstrual cycle in women). Such hormones are highly lipophilic and pass readily from the plasma to the brain where they can influence neuronal function. It is becoming clear that the rapid reduction in peripheral circulating progesterone, which occurs during the late diestrous phase of the cycle, can trigger a withdrawal-like response, in which changes in GABAA receptor expression render hyper-responsive certain brain areas involved in processing responses to stressful stimuli. The periaqueductal gray matter (PAG) is recognised as an important region for integrating anxiety/defence responses. Withdrawal from progesterone, via actions of its neuroactive metabolite allopregnanolone, triggers up-regulation of extrasynaptic GABAA receptors on GABAergic neurons in the PAG. As a consequence, ongoing GABAergic tone on the output cells decreases, leading to an increase in functional excitability of the circuitry and enhanced responsiveness to stressful stimuli during the late diestrous phase. These changes during late diestrus could be prevented by short-term neurosteroid administration, timed to produce a more gradual fall in the peripheral concentration of allopregnanolone than the rapid decrease that occurs naturally, thus removing the trigger for the central withdrawal response.

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“…Levels of the most prominent physiological estrogens rise dramatically during pregnancy (see Figure 1), and return to prepregnancy levels very rapidly after parturition; this abrupt change can be correlated with the onset of postpartum depression 29. Levels of these hormones also vary widely between the sexes, and between women’s cycle stages and life stages (Figure 2).…”

Section: Life Stage-specific Fluctuating Levels Of Several Physiologmentioning

confidence: 99%

Estrogens of multiple classes and their role in mental health disease mechanisms

Watson¹,

Alyea

Cunningham³

et al. 2010

IJWH

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Gender and sex hormones can influence a variety of mental health states, including mood, cognitive development and function, and vulnerability to neurodegenerative diseases and brain damage. Functions of neuronal cells may be altered by estrogens depending upon the availability of different physiological estrogenic ligands; these ligands and their effects vary with life stages, the genetic or postgenetic regulation of receptor levels in specific tissues, or the intercession of competing nonphysiological ligands (either intentional or unintentional, beneficial to health or not). Here we review evidence for how different estrogens (physiological and environmental/dietary), acting via different estrogen receptor subtypes residing in alternative subcellular locations, influence brain functions and behavior. We also discuss the families of receptors and transporters for monoamine neurotransmitters and how they may interact with the estrogenic signaling pathways.

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Abrupt rather than gradual hormonal changes induce postpartum blues-like behavior in rats

Cited by 32 publications

References 35 publications

A specific profile of luteal phase progesterone is associated with the development of premenstrual symptoms

A specific profile of luteal phase progesterone is associated with the development of premenstrual symptoms

Estrous cycle and stress: influence of progesterone on the female brain

Estrogens of multiple classes and their role in mental health disease mechanisms

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