Absceso cerebral por Actinomyces meyeri

Actinomyces meyeri Causing Cerebral Abscess in a Patient on Methotrexate: A Rare Case Report and Systematic Review of the Literature

“…The CNS is rarely affected by A. meyeri and usually presents as brain abscesses. In year 2017, Guillamet et al [2] reported a case of a brain abscess caused by A. meyeri and identified seven other cases [3][4][5][6][7][8] in the literature. We performed a systematic review of the literature, following Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) guidelines.…”

Emerging role of Actinomyces meyeri in brain abscesses: A case report and literature review

“…Anecdotal data suggests successful treatment of extensive actinomycosis with antibiotic therapy alone, mostly for pelvic disease [11] , [12] , [13] , [14] . We found two case reports of patients with A. meyeri brain abscesses who required surgical drainage after failing antibiotic therapy alone [6] , [15] and an exceptional case of a 2 cm Actinomyces odontolyticus brain abscess successfully treated with 6 months of penicillin alone [12] .…”

“…He was discharged to an acute rehabilitation facility with oral doxycycline and intravenous vancomycin and metronidazole. Although systemic availability of metronidazole has been shown to be similar following oral and intravenous administration [3] , intravenous administration is often recommended for the treatment of life-threatening infections [4] , [5] , [6] , at least for initial therapy. We also opted for intravenous metronidazole over oral for ease of administration.…”

Brain Abscess: A Rare Clinical Case with Oral Etiology

“…Actinomyces meyeri is usually found in the periodontal sulcus [19,34,37,38], and while it is considered a low-virulence bacteria in immunocompetent individuals, there are risk factors identified for Actinomyces infection including poor oral hygiene, abusive alcohol intake, pulmonary infection, and recent dental treatment [17,30,34,36,38]. Its infection is usually restricted to the cervicofacial region, with the central nervous system rarely affected [15,17,28,34,36,[38][39][40][41], accounting for approximately 3% of actinomycosis [33,35,42]. Infection by Actinomyces meyeri itself is very rare [28,30,35], accounting for only 1% of all Actinomyces spp.…”

“…Its infection is usually restricted to the cervicofacial region, with the central nervous system rarely affected [15,17,28,34,36,[38][39][40][41], accounting for approximately 3% of actinomycosis [33,35,42]. Infection by Actinomyces meyeri itself is very rare [28,30,35], accounting for only 1% of all Actinomyces spp. involved in human pathogenesis [31,39].…”