Abscisic Acid Treatment in Patients with Prediabetes

Abstract

Aim: to evaluate the effects of abscisic acid (ABA), contained in dwarf peaches, on the regression of impaired fasting glucose (IFG) or impaired glucose tolerance (IGT) conditions. Materials and methods: sixty-five patients with IFG or IGT were randomized to take ABA or placebo for 3 months. We evaluated: fasting plasma glucose (FPG), postprandial plasma glucose (PPG), glycated hemoglobin (HbA1c), fasting plasma insulin (FPI), homeostatic model assessment of insulin resistance (HOMA-IR), lipid profile and high sensitivity C-reactive protein (Hs-CRP). At baseline, and after 3 months, all patients underwent an oral glucose tolerance test (OGTT), an euglycemic hyperinsulinemic clamp, and a glucagon test. Results: a significant reduction of HbA1c, FPG, PPG, FPI and HOMA-IR was observed in the ABA group. After 3 months, 26.7% of patients returned to a normal glycemic status in the ABA group versus zero patients in placebo group; 20.0% were classified as IFG and 53.3% as IGT in the nutraceutical group versus 33.3% and 63.3% in the placebo group. The M value was higher in the ABA group at the end of the treatment. Finally, Hs-CRP was reduced after 3 months of ABA consumption. Conclusions: abscisic acid can be effective in ameliorating glyco-metabolic compensation and in reducing inflammatory status in patients with IFG or IGT.

Phenolic compounds, amino acid profiles, and antibacterial properties of kefir prepared using freeze‐dried Arbutus unedo L. and Tamarindus indica L. fruits and sweetened with stevia, monk fruit sweetener, and aspartame

“…Abscisic acid was determined between 56.68 and 247.63 ng ml −1 in all fruity samples. Derosa et al (2020) studied the efficacy of abscisic acid in the treatment of patients with prediabetes and obtained positive results. Quercetin is the major phenolic component of kefir samples after gallic acid and was detected only in kefir samples added with Arbutus unedo L. fruit.…”

“…acid was determined between 56.68 and 247.63 ng ml −1 in all fruity samples Derosa et al (2020). studied the efficacy of abscisic acid in the treatment of patients with prediabetes and obtained positive results.…”

The ABA-LANCL1/2 Hormone-Receptors System Protects H9c2 Cardiomyocytes from Hypoxia-Induced Mitochondrial Injury via an AMPK- and NO-Mediated Mechanism

“…Defective endogenous ABA has been observed in both T1D and T2D [ 12 , 55 ], suggesting that endogenous ABA deficiency may play a role in the pathogenesis of glucose intolerance due to insulin deficiency or resistance. Indeed, oral ABA has been shown to improve glucose tolerance in borderline and prediabetic subjects [ 56 , 57 ] and to improve insulin sensitivity in murine models of T1D [ 58 ]. From the data presented here, we hypothesize that the impaired endogenous ABA function occurring in diabetes could contribute to the reduced resilience of cardiomyocytes to the ultimate stressor of these cells, i.e., hypoxia.…”

Efectos neuroprotectores del ácido abscísico sobre la línea celular SH-SY5Y en condiciones proinflamatorias

“…De hecho, recientes evidencias apuntan a que diferentes células inmunes animales son capaces de sintetizar AbA (Lievens et al 2017). Esta molécula ha mostrado efectos antiinflamatorios, tanto de forma periférica (Derosa et al 2020;Magnone et al 2020), como a nivel del sistema nervioso central (Espinosa et al 2019), con efectos sensibilizadores de insulina periférica (Jeon et al 2020) y efectos beneficiosos ante el deterioro cognitivo (Sánchez et al 2016). Además, AbA ha mostrado incrementar la expresión de IRS1 e IRS2 en modelos animales de neuroinflamación inducida por dieta grasa (Ribes et al 2019).…”