Absence of analgesic effect of intravenous melatonin administration during daytime after laparoscopic cholecystectomy: a randomized trial

Andersen, Lars Peter Holst; Kücükakin, Bülent; Werner, Mads U.; Rosenberg, Jacob; Gögenur, Ismail

doi:10.1016/j.jclinane.2014.03.008

Cited by 18 publications

(35 citation statements)

References 31 publications

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“…Although some trainings indicate that preoperative administration of melatonin can decrease postoperative pain and reduce narcotic intake, its effect on pain and anxiety has not yet been clarified to be recommended widely. In addition, some other studies have found contentious results in this regard (11, 12). …”

Section: Introductionmentioning

confidence: 95%

Comparison of Effects of Melatonin and Gabapentin on Post Operative Anxiety and Pain in Lumbar Spine Surgery: A Randomized Clinical Trial

et al. 2018

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BackgroundSurgery is one of the stressors that cause physiological and psychological stress. Anxiety and pain and their complications are very important in anesthesiology and many researches have been done to decrease or eliminate them. This training was done to compare the effect of melatonin and gabapentin on pain and anxiety during lumbar surgery.MethodsThis study was a double-blinded clinical trial conducted on 90 patients undergoing lumbar surgery with general anesthesia in Golestan Academic Hospital in 2017. Patients were randomly assigned into 3 groups: 30 patients received 6 mg melatonin, 30 patients received 600 mg gabapentin, and 30 patients were on placebo (control), 100 minutes preoperatively. All patients were given a fixed method of anesthesia. The pain intensity and patients’ satisfaction from analgesia measured at 1, 2, 6, 12, and 24 h after surgery. The anxiety was measured 15 minutes before surgery and 1, 2, 6, 12, and 24 h after surgery.ResultsIn our study, there was a significant difference between mean Visual Analog Score between melatonin and gabapentin groups in comparison to placebo (P = 0.02). The intensity of anxiety among the groups was lower in melatonin and gabapentin groups in comparison to placebo (P = 0.01).ConclusionsThe results show that pretreatment with melatonin or gabapentin decreases anxiety and pain in lumbar surgery.

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Section: Introductionmentioning

confidence: 95%

Comparison of Effects of Melatonin and Gabapentin on Post Operative Anxiety and Pain in Lumbar Spine Surgery: A Randomized Clinical Trial

et al. 2018

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“…Non-steroidal anti-inflammatory agents, intravenous opioids, local anesthetic (LA) infiltration of incision sites, preemptive analgesia methods, and regional anesthesia techniques are used in multimodal analgesia (1,(6)(7)(8)(9) . The regional anesthesia techniques include the transverse abdominis plane (TAP) block, oblique subcostal transverse abdominis plane (OSTAP or STAP) block, and paravertebral block (6)(7)(8)(9) . Because these techniques other than paravertebral block only affect somatic pain, they might be inadequate in some cases (10) .…”

Section: Introductionmentioning

confidence: 99%

The Efficacy of Ultrasound-Guided Erector Spinae Plane Block for Postoperative Analgesia in Laparoscopic Cholecystectomy. A Retrospective Cohort Study

Karaca¹,

Pınar²

2020

JARSS

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Objective: Laparoscopic cholecystectomy (LC) causes moderate to severe pain. Although it is a minimal invazive surgery, evaluation of the efficacy and safety of ultrasound guided-bilateral erector spinae plane block (ESPB) in the the present study Method: A total of 234 patients who underwent LCs between April 2017 and November 2018 were retrospectively analyzed. Two hundred patients were divided into two groups: The Control Group (Group C, n=100) who received only intravenous (IV) patient-controlled analgesia (PCA) and the ESPB Group (Group E, n=100) who received bilateral ESPB (bupivacaine 0.25, 50 mL) and IV PCA. Also, the block-related complications were recorded. Results: Numeric rating scores in Grup E were lower in post-anesthesia care unit (PACU) at 1 st , 2 nd , 4 th , 6 th hours (p<0.0001) and 8 th hour (p<0.05). The fentanyl consumption during postoperative period was lower in Group E (p<0.0001). PACU and hospital stay were shorter in Group E (p<0.0001). Need for rescue analgesic was lower in Group E (p<0.0001). Intraoperative fentanyl requirement was lower in Group E (p<0.0001). Unassisted walking time was shorter in Group E (p<0.0001). The incidence of nausea and vomiting was lower in Group E (p<0.05). No block-related complications were encountered. Conclusion:Bilateral ultrasound-guided ESPB provides better analgesia and shortens unassisted walking time and hospital stay after laparoscopic cholecystectomy.

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“…Melatonin does not exhibit toxicity at the doses used [ 28 ]; even high-dose intravenous melatonin (100 mg) does not induce significant adverse effects [ 29 – 32 ]. Although some clinical trials have reported the anti-nociception effects of melatonin [ 33 – 45 ], several other studies have shown that melatonin has no significant effects on pain [ 16 , 30 , 46 , 47 ].…”

Section: Introductionmentioning

confidence: 99%

Exogenous melatonin in the treatment of pain: a systematic review and meta-analysis

Zhu

Duan

et al. 2017

Oncotarget

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Melatonin is an important hormone for regulating mammalian circadian biology and cellular homeostasis. Recent evidence has shown that melatonin exerts anti-nociception effects in both animals and humans. However, according to clinical trials, the anti-nociception effects of melatonin are still controversial. The aim of this meta-analysis was to investigate the anti-nociception effects of melatonin premedication. The primary outcome was the effects of melatonin on pain intensity. The secondary outcomes included the number of patients with analgesic requirements, total analgesic consumption, and brain-derived neurotrophic factor (BDNF) levels. In total, 19 studies were included in the current meta-analysis. The pooling data show that melatonin significantly decreased the pain intensity, as evidenced by the pain scores. Moreover, melatonin administration also reduced the proportion of patients with analgesic requirements and BDNF levels. However, the effects of melatonin on total analgesic consumption still require further confirmation. Collectively, the current meta-analysis supports the use of melatonin for anti-nociception.

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Absence of analgesic effect of intravenous melatonin administration during daytime after laparoscopic cholecystectomy: a randomized trial

Cited by 18 publications

References 31 publications

Comparison of Effects of Melatonin and Gabapentin on Post Operative Anxiety and Pain in Lumbar Spine Surgery: A Randomized Clinical Trial

Comparison of Effects of Melatonin and Gabapentin on Post Operative Anxiety and Pain in Lumbar Spine Surgery: A Randomized Clinical Trial

The Efficacy of Ultrasound-Guided Erector Spinae Plane Block for Postoperative Analgesia in Laparoscopic Cholecystectomy. A Retrospective Cohort Study

Exogenous melatonin in the treatment of pain: a systematic review and meta-analysis

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