Absence of antibodies to native type I and type II collagen in a rabbit model of osteoarthritis

Charrière, G; Ville, G.; Vignon, E.; Béjui, J.

doi:10.1002/anr.1780320629

Cited by 4 publications

(1 citation statement)

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“…Autoimmunity to type II collagen is rare in generalized nodal osteoarthritis [23]. Furthermore, no antibodies type II collagen exist in the rabbits with osteoarthritis of the knee occurring after meniscectomy [24]. These finding suggest that even if cartilage is destroyed and type II collagen is exposed as a potential autoantigen in OA mice, they may not become sensitized to it.…”

Section: Discussionmentioning

confidence: 98%

Absence of immunity to type II collagen and proteoglycan in osteoarthritic C57BL mice

et al. 1995

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We measured immunity to type II collagen and proteoglycans in osteoarthritic C57BL mice to determine whether it is related to osteoarthritis pathogenesis. Histological examination revealed articular cartilage lesions in all mice and synovitis in only a few mice. Immunological responses to type II collagen were found in collagen arthritic mice, but not in C57BL mice. Furthermore, immunological responses to proteoglycans were observed in proteoglycan-immunized mice, but not in C57BL mice. Therefore, articular cartilage degeneration may not result in autoimmunity to type II collagen and proteoglycans in osteoarthritis of C57BL mice, and immune responses to these components may not be a primary etiology of osteoarthritis in this model.

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Section: Discussionmentioning

confidence: 98%