Absence of antibody to cyclic citrullinated peptide in sera of non-arthritic patients with chronic hepatitis B virus infection

Abstract

The objective of this study was to investigate if antibody to cyclic citrullinated peptide (anti-CCP) is detected in sera of patients with chronic hepatitis B virus (HBV) infection. Serum anti-CCP and IgA, IgG, and IgM rheumatoid factor (RF) isotypes were measured by enzyme-linked immunosorbent assay on 176 non-arthritic patients with HBV infection. IgA RF, IgG RF, and IgM RF were detectable in 29.5, 21, and 18.8% of the tested sera, respectively, with a total seropositivity rate of 42.7%. Marginally elevated anti-CCP was detected in one patient (0.6%). By regression analysis, there was no statistically significant association between the serum levels of anti-CCP and serum IgA, IgG, or IgM RF (R (2) = 0.033, with respective p values of 0.224, 0.297, and 0.334). In conclusion, anti-CCP was rarely detected in non-arthritic patients with HBV infection in contrast to RF. Thus, testing for anti-CCP may be a useful tool for the diagnosis of rheumatoid arthritis in this population.

Anti-cyclic citrullinated peptide and rheumatoid factor in HIV positive patients

“…Median value for anti-CCP was higher than the normal range suggested by the manufacturer of the test (<5 U/ml) (Results, Table 1). This data is additionally interesting because clinical investigations on patients infected with hepatitis C as well as the patients with chronic hepatitis B did not conWrm the presence of elevated anti-CCP values [12,13].…”

Hepatitis B Virus (HBV) and Autoimmune Disease

“…Patients with chronic HBV may contain RF (especially the IgA isotype) in 20-75% of the cases but rarely do they contain anti-CCP. Therefore, even in the presence of RF, arthralgia or arthritis related with chronic hepatits B, patients do not develop or suffer from RA [54].…”

“…There is some evidence suggesting a pathologic link between HBV and RA [13,54]. Patients with chronic hepatitis B virus may have arthralgia or arthritis similar to rheumatoid arthritis (RA) [37,54].…”

“…Patients with chronic hepatitis B virus may have arthralgia or arthritis similar to rheumatoid arthritis (RA) [37,54].…”

Chronic arthritis in patients with hepatitis virus В and С infection

“…При этом важным диагностическим признаком служит наличие в крови HBs антигена. Содержание АЦЦП при ХГС обычно не повышает-ся, поэтому данные признак может быть использо-ван для дифференциальной диагностики с РА [56]. Основными препаратами для лечения хронической ВГВ инфекции являются ИФНα и аналоги нуклео-тидов (ламивудин, адефовир, ентекавир и др.)…”