Absence of antihyperglycemic effect of jambolan in experimental and clinical models

Teixeira, Claudio Coimbra; Rava, Carlos Augusto; Silva, Paula Mallman da; Melchior, Raquel; Argenta, Rodrigo; Anselmi, Fabio; Almeida, Claudia Rejane Chiarel; Fuchs, Flávio Danni

doi:10.1016/s0378-8741(00)00185-9

Cited by 69 publications

(50 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Nevertheless, investigations carried out in Brazil have shown that the leaves and the fruits of Syzygium cumini did not have effect on diabetes (Pepato et al, 2005;Teixeira et al, 1990;Teixeira et al, 1997;Teixeira et al, 2000). In this work there was no change in the seric concentration of glucose in animals treated for 30, 90 and 180 days with the Syzygium cumini HE (Tables 1, 2 extract-treated groups were significantly lower than the control group.…”

Section: Resultscontrasting

confidence: 43%

The toxicity evaluation of Syzygium cumini leaves in rodents

Silva¹,

Abreu²,

Silva³

et al. 2012

Rev. bras. farmacogn.

View full text Add to dashboard Cite

This study aimed to evaluate the safety of the hydroalcoholic extract (HE) of Syzygium cumini (L.) Skeels, Myrtaceae, leaves in rodents. Acute toxicity was evaluated through the determination of a LD50 in mice and rats (up to 14 days). In mice, the oral administration (p.o.) of the HE (0.1 at 6 g/kg) did not cause any death. When administered by intraperitoneal route (i.p.) the HE (0.1 at 1 g/kg) caused death of the animals (LD50 of 0.489 g/kg). In rats, the HE (0.5, 1 and 2 g/kg, p.o.) did not cause any death, while by i.p., only the 2 g/kg dose was lethal to 67% of the animals. To evaluate chronic toxicity, groups of rats daily received the HE (0.05, 0.1 and 0.25 g/kg) through p.o., during 30, 90 or 180 days and the effects on behavior, body weight, feed consumed were measured. Histology, hematology and biochemical parameters were measured at the end of the treatment. After a 30-day treatment, the HE caused changes in some biochemical parameters. Histological examination of the liver, kidneys, lungs, heart, stomach, intestine and pancreas showed normal architecture suggesting no morphological disturbances. These data may mean that the HE of S. cumini does not exert acute or chronic toxic effects by oral administration.

show abstract

Section: Resultscontrasting

confidence: 43%

The toxicity evaluation of Syzygium cumini leaves in rodents

Silva¹,

Abreu²,

Silva³

et al. 2012

Rev. bras. farmacogn.

View full text Add to dashboard Cite

show abstract

“…It was found, however, that S. jambos collected in southern Brazil and prepared by these methods did not affect the glycemia of normal individuals (5). Subsequent studies on normal and streptozotocindiabetic rats have also shown that aqueous extracts and decoctions of southern Brazilian E. jambolana have no hypoglycemic effects (2,23).…”

Section: Introductionmentioning

confidence: 99%

Lack of antidiabetic effect of a Eugenia jambolana leaf decoction on rat streptozotocin diabetes

Pepato

Folgado

Kettelhut

et al. 2001

Braz J Med Biol Res

View full text Add to dashboard Cite

Streptozotocin-diabetic rats were treated for 17 days with a decoction of Eugenia jambolana (Myrtaceae) leaves (15%, w/v) as a substitute for water. Body weight, food and fluid intake, urine volume, glycemia, urinary glucose and urea were evaluated every 5 days. The animals were sacrificed by decapitation and blood samples collected for the determination of glycemia, serum cholesterol, HDL-cholesterol, triglycerides and angiotensin-converting enzyme. The weight of adipose and muscle tissues was also determined. There were no statistically significant differences between treated and untreated rats for any of the biochemical or physiological parameters. We conclude that, at least in this experimental model, Eugenia jambolana leaf decoction has no antidiabetic activity.

show abstract

“…Bark, leaves and fruits of S. cumini have been used in traditional medicine since ancient times 1,2 . Extracts of S. cumini are well known as hypoglycemic and antidiabetic agents, although results of pre-clinical or clinical studies have been controversial [3][4][5][6][7][8] , and they are also described for their diuretic 9 , bactericidal 10,11 and anti-inflammatory [12][13][14] , and for treatment of dysentery 15 . The leaves are rich in tannins 3,16 , flavonoids 17,18 , and essential oils 11,19 .…”

Section: Introductionmentioning

confidence: 99%

Correlation of anti-inflammatory activity with phenolic content in the leaves of syzygium cumini (l.) skeels (myrtaceae)

Lima¹,

Siani²,

Brito³

et al. 2007

Quím. Nova

View full text Add to dashboard Cite

Recebido em 2/5/06; aceito em 6/10/06; publicado na web em 28/5/07Phenolic contents of extracts of Syzygium cumini leaves, collected monthly over a one-year period, were quantitatively determined by the modified Folin-Ciocalteau method. Extracts and tannin-free fractions were assayed by their potential to inhibit mouse paw edema induced by C48/80. HPLC showed high molecular weight phenolic species and flavonoids in the active extracts and fractions. The highest total phenolic content corresponded to the most potent degree of inhibition and the flavonoids were supposed to be the main species responsible for the activity, given that the flavonoid-enriched ethyl-acetate fraction maintained its effect down to a dose of 0.01 µg/kg in a dose-response manner.

show abstract

Absence of antihyperglycemic effect of jambolan in experimental and clinical models

Cited by 69 publications

References 7 publications

The toxicity evaluation of Syzygium cumini leaves in rodents

The toxicity evaluation of Syzygium cumini leaves in rodents

Lack of antidiabetic effect of a Eugenia jambolana leaf decoction on rat streptozotocin diabetes

Correlation of anti-inflammatory activity with phenolic content in the leaves of syzygium cumini (l.) skeels (myrtaceae)

Contact Info

Product

Resources

About