Absence of circadian variations in urinary porphyrin excretion in normal subjects

Melatonin and epileptic seizures in patients with acute intermittent porphyria

“…In contrast, the urinary excretion of porphyrin does not display a circadian variation in healthy persons without AIP [16]. Melatonin exerts a depressive influence on brain excitability [17, 18] and has been shown to have an anti‐convulsive effect in animal models [18‐20] and in humans [18, 21].…”