2023
DOI: 10.3390/nu15081995
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Absence of Effects of L-Arginine and L-Citrulline on Inflammatory Biomarkers and Oxidative Stress in Response to Physical Exercise: A Systematic Review with Meta-Analysis

Abstract: Background: The repercussions on oxidative and inflammatory stress markers under the effects of arginine and citrulline in response to exercise are not fully reached. We completed a systematic review to investigate the effects of L-Citrulline or L-Arginine on oxidative stress and inflammatory biomarkers following exercise. EMBASE, MEDLINE (PubMed), Cochrane Library, CINAHL, LILACS, and Web of Science databases were used to record the trials. This study includes randomized controlled trials (RCTs) and non-RCTs … Show more

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Cited by 3 publications
(2 citation statements)
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“…Therefore, an important strategy for post-exercise recovery is needed, where muscle fibers produce and release pro-inflammatory myokines such as IL-6 when physically active. In inflammatory situations, other myokines such as TNF-α and IL-10 are also expressed (Santoso et al, 2019;Porto et al, 2023;Volpe-Fix et al, 2023). TNF-α is one part of the pro-inflammatory cytokines that trigger muscle pain (Fernández-Lázaro et al, 2020;Ayubi et al, 2022;Nanavati et al, 2022).…”
Section: Discussionmentioning
confidence: 99%
“…Therefore, an important strategy for post-exercise recovery is needed, where muscle fibers produce and release pro-inflammatory myokines such as IL-6 when physically active. In inflammatory situations, other myokines such as TNF-α and IL-10 are also expressed (Santoso et al, 2019;Porto et al, 2023;Volpe-Fix et al, 2023). TNF-α is one part of the pro-inflammatory cytokines that trigger muscle pain (Fernández-Lázaro et al, 2020;Ayubi et al, 2022;Nanavati et al, 2022).…”
Section: Discussionmentioning
confidence: 99%
“…The inflammatory response due to exercise triggers a decrease in muscle strength, (Ayubi, Kusnanik, Herawati, Muhammad, et al, 2023). In inflammatory situations, other myokines such as TNF-α and interleukin-10 IL-10 are also expressed (Porto et al, 2023;Volpe-Fix et al, 2023). TNF-α is one part of the pro-inflammatory cytokines that trigger muscle pain (Fernández-Lázaro et al, 2020;Ayubi et al, 2022;Nanavati et al, 2022).…”
Section: Discussionmentioning
confidence: 99%